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  1. 1781
  2. 1782
  3. 1783
    “…Among the preferential pNEDD8 interactors are HSP70 family members and we show that pNEDD8 stimulates HSP70 ATPase activity more pronouncedly than unmodified NEDD8. …”
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  4. 1784
    “…Modification of telomeric DNA by oxidation is emerging as a marker of genotoxic damage and is associated with reduced genome integrity and changes in telomere length and telomerase activity. 8-oxoguanine (8-oxoG) is the most studied and common outcome of oxidative damage in DNA. …”
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  5. 1785
    “…Though the high-resolution three-dimensional structures of the menthol receptor, the transient receptor potential melastatin 8 (TRPM8) ion channels, have been revolved in different states, the menthol-bound state structure is not determined and how the stereoisomers of menthol interact with TRPM8 remains largely elusive. …”
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  6. 1786
    “…We detail the role of PAX8 in each of these organ systems, describe its role during development and in the adult if known, and highlight its pro-tumorigenic role in cancers that emerge from PAX8 expressing organs.…”
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  7. 1787
    “…Here, we discuss recent crystal structures of inactive C5aR1 in terms of an inverted orientation of helix H8, unobserved in other GPCR structures. An analysis of mutual interactions of subunits in the C5aR1—G protein complex has provided new insights into the activation mechanism of this distinct receptor. …”
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  8. 1788
    “…[Image: see text] Use of the 1,3,5-tri(2-hydroxyethyl)-1,3,5-triazacyclohexane ligand, LH(3), in manganese chemistry affords access to two structurally related {Mn(8)} clusters: a “closed” {Mn(III)(6)Mn(II)(2)} puckered square wheel of formula [Mn(8)L(2)(LH)O(3)(OH)(2)(MeO)(2)Br(imH)(H(2)O)(3)](Br)(3) (1; imH = imidazole) and an “open” {Mn(III)(8)} rod of formula [Mn(ΙΙΙ)(8)L(2)O(4)(aibH)(2)(aib)(2)(MeO)(6)(MeOH)(2)](NO(3))(2) (2, aibH = 2-amino-isobutyric acid). …”
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  9. 1789
  10. 1790
  11. 1791
    “…Interferon regulatory factor 8 (IRF8) is a transcription factor of the IRF protein family. …”
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  12. 1792
    por Wang, Qiankun, Shan, Liang
    Publicado 2022
    “…Med. https://doi.org/10.1084/jem.20212117) identify CARD8 as an innate sensor triggered by coxsackievirus B3 proteases to drive pyroptosis of aortic endothelial cells and cardiac myocytes, fueling viral replication and heart inflammation.…”
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  13. 1793
    “…Histone deacetylase 8 (HDAC8) is a class I HDAC that catalyzes the deacetylation of histone and non-histone proteins. …”
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  14. 1794
    por Wu, Duojiao, Chen, Yuwen
    Publicado 2022
    “…It is reported that tumor-infiltrating CD8(+)T lymphocytes (CD8(+)TILs) burn fats to restore their impaired effector function due to the lack of glucose. …”
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  15. 1795
  16. 1796
  17. 1797
  18. 1798
  19. 1799
  20. 1800
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