“…On 50 mg film-coated tablets or 30 mg dispersible tablets, C(trough) was close to the adult reference (with similar estimates on the two formulations in children in the 20 to <25 kg weight band), with total exposure (area under the concentration-time curve from 0 h to 24 h) in between reference values in adults dosed once and twice daily, where safety data are reassuring, although maximum concentrations were higher in children weighing 20 kg to less than 25 kg than in the twice-daily adult reference. Over a 24-week follow-up period in 47 children on 30 mg dispersible tablets or 50 mg film-coated tablets, none of the three reported adverse events (cryptococcal meningitis, asymptomatic anaemia, and asymptomatic neutropenia) were considered related to dolutegravir. …”
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“…Staff intensivists will monitor the patient’s status in both groups on a 24/7 basis. All other treatment will be unchanged and left to the attending physicians. …”
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“…Adults (aged 18–70 years) with histologically diagnosed diffuse large B-cell lymphoma and CNS involvement at the time of primary diagnosis or at relapse and Eastern Cooperative Oncology Group Performance Status of 3 or less were enrolled and received three courses of MATRix (rituximab 375 mg/m(2), intravenous infusion, day 0; methotrexate 3·5 g/m(2), the first 0·5 g/m(2) in 15 min followed by 3 g/m(2) in a 3 h intravenous infusion, day 1; cytarabine 2 g/m(2) every 12 h, in 1 h intravenous infusions, days 2 and 3; thiotepa 30 mg/m(2), 30 min intravenous infusion, day 4) followed by three courses of RICE (rituximab 375 mg/m(2), day 1; etoposide 100 mg/m(2) per day in 500–1000 mL over a 60 min intravenous infusion, days 1, 2, and 3; ifosfamide 5 g/m(2) in 1000 mL in a 24 h intravenous infusion with mesna support, day 2; carboplatin area under the curve of 5 in 500 mL in a 1 h intravenous infusion, day 2) and carmustine–thiotepa and autologous HSCT (carmustine 400 mg/m(2) in 500 mL glucose 5% solution in a 1–2 h infusion, day −6; thiotepa 5 mg/kg in saline solution in a 2 h infusion every 12 h, days −5 and −4). …”
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“…The Mario Pinotti II (MPII) study is a 24-week observational study that conducted scheduled telephone calls every 2 weeks to verify the occurrence of COVID-19 in patients with rheumatic diseases on chronic hydroxychloroquine therapy (from March 29, 2020, to September 30, 2020). …”
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“…RESULTS: Fifty-seven participants were randomly assigned to each group of which 42 in the tenodesis group and 45 in the tenotomy group completed a 24-month follow-up. The overall incidence of popeye deformity based on clinical assessment was 21%, 9.5% (4/42) in the tenodesis group and 33% (15/45) in the tenotomy group. …”
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“…RESULTS: EFFECT OF BILIARY OCCLUSION: Total biliary occlusion (tBDT) led to a 2.4-fold increase in whole liver volume due to severe biliary proliferation within 14 days. …”
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“…CONCLUSIONS AND RELEVANCE: In this pivotal randomized clinical trial, vamorolone was shown to be effective and safe in the treatment of boys with DMD over a 24-week treatment period. Vamorolone may be a safer alternative than prednisone in this disease, in which long-term corticosteroid use is the standard of care. …”
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“…The small 2.1% increase in PMPM costs for the 3 formerly PA-exempt drug classes was attributable in part to a 12.9% reduction in average cost per pharmacy claim, from $94.05 to $81.92, including a 24.8% reduction in the average cost per antidepressant claim, from $65.59 to $49.33. …”
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“…For three consecutive cycles in a 24/4-day regimen, participants received 5 mg or 10 mg E(4)/3 mg drospirenone (DRSP); 5 mg, 10 mg or 20 mg E(4)/150 μg levonorgestrel; or 20 μg ethinylestradiol (EE)/3 mg DRSP as comparator. …”
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“…Participants received 5 mg or 10 mg E(4)/3 mg DRSP; 5 mg, 10 mg or 20 mg E(4)/150 μg LNG; or 20 μg EE/3 mg DRSP as a comparator for three consecutive cycles in a 24/4-day regimen. Changes from baseline to end of treatment in liver parameters, lipid metabolism, bone markers and growth endocrinology were evaluated. …”
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“…Positron emission tomography with 2-deoxy-2-[fluorine-18] fluoro-d-glucose integrated with CT (18F-FDG PET/CT) scan showed widespread adenopathy, diffuse splenic involvement, and substantial marrow involvement. Biopsy of a 2.4-cm right axillary node (SUVmax of 16.1) showed involvement by grade 3A FL with a predominant nodular pattern of growth. …”
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“…Similar studies were performed in haloperidol-decanoate or vehicle (sesame oil) treated rats (intramuscular injection every 3 weeks for 9 months). RESULTS: We found a 24% decrease in PFK1 mRNA expression in the dorsolateral prefrontal cortex in schizophrenia (p=0.039). …”
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“…Overall, statin or more intensive therapy yielded a 24% (RR 0·76, 95% CI 0·73–0·79) proportional reduction in major coronary events per 1·0 mmol/L reduction in LDL cholesterol, and with increasing age, we observed a trend towards smaller proportional risk reductions in major coronary events (p(trend)=0·009). …”
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“…METHODS AND FINDINGS: A multicenter, open-label, 24-week trial (VBP15-003) with a 24-month long-term extension (VBP15-LTE) was conducted by the Cooperative International Neuromuscular Research Group (CINRG) and evaluated drug-related effects of vamorolone on motor outcomes and corticosteroid-associated safety concerns. …”
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“…La durée moyenne de séjour est identique dans les deux groupes à 24 jours mais la mortalité en réanimation des patients CPAVM est significativement plus important avec 22 (52 %) patients décédés en réanimation contre 54 (30 %) pour les NCPAVM. …”
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“…When stratifying by Rh factor, there was also no significant difference in incidence of thrombosis by blood types: A- (11.1%), A+ (24.1%), AB- (0%), AB+ (15.8%), B- (25%), B+ (20.3%), O- (18.2%), O+ (18.7%) (p=0.9054). …”
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“…Lastly, almost all patients indicated an interest in having access to a 24-hour hotline for SCD care (94%). Conclusion: The utilization of CBOs to provide ancillary support services is necessary to continue to understand patient needs, not only during a global crisis but after for routine health care. …”
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“…This provides an example of immunologic escape similar to what has been described for the Delta variant in the case of HLA-A24. These data are consistent with the hypothesis that immunodominant epitopes will be preferentially eliminated as the virus continues to evolve. …”
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“…Il n'y avait pas de différence significative du nombre de patients en réanimation au moment de la perfusion d'AC entre les groupes ayant présenté ou non une DR (11,3 vs 5,7 %, p= 0,306). A 24h, il y avait plus de patients en réanimation dans le groupe ayant présenté une DR (36,4 vs 5,7 %, p<0,001). …”
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“…We found that the DNA vaccine with this mutant HPV18 E6 generated E6-specific CD8 + T cells in HLA-A2. HLA-A11, HLA-A24 and HLA-b40 transgenic mice. Of note, HLA-A2 restricted, HPV18 E7 peptide (aa7-15)- and HPV18 E6 peptide (aa97-105)-specific epitopes are endogenously processed by HPV18 positive Hela-AAD (HLA-A(*)0201/D(d)) cells. …”
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