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  1. 1
    “…The heterodimeric adenosine deaminases acting on tRNAs (ADAT2-ADAT3, or ADAT) are enzymes present in eukaryotes that convert adenine (A) to inosine (I) in the first anticodon base (position 34) by hydrolytic deamination. …”
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    Distribution of ADAT-Dependent Codons in the Human Transcriptome
  2. 2
    “…The eukaryotic wobble adenosine-to-inosine modification is catalysed by the ADAT (ADAT2/ADAT3) complex that modifies up to eight tRNAs, requiring a full tRNA for activity. …”
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    The structure of the mouse ADAT2/ADAT3 complex reveals the molecular basis for mammalian tRNA wobble adenosine-to-inosine deamination
  3. 3
    “…Experimental data resulting from the assay is provided by SomaLogic in a proprietary text-based format called ADAT. This manuscript describes a user-friendly point and click open source, platform-independent software tool designed to be used for navigating and plotting data from an ADAT file. …”
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    Web Tool for Navigating and Plotting SomaLogic ADAT Files
  4. 4
    “…This modification is produced via deamination on A34 and catalyzed by the adenosine deaminase acting on tRNA (ADAT) enzyme. Eukaryotic ADATs are heterodimers composed of the catalytic subunit ADAT2 and the structural subunit ADAT3, but their molecular assemblies and catalytic mechanisms are largely unclear. …”
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    Crystal structure of the yeast heterodimeric ADAT2/3 deaminase
  5. 5
    “…RESULTS: readat is an R package for working with the SomaLogic ADAT file format. It provides functionality for importing, transforming and annotating data from these files. …”
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    readat: An R package for reading and working with SomaLogic ADAT files
  6. 6
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    Adolescents diabetes awareness test (ADAT): Tool development and psychometrics evaluation research
  7. 7
    “…A heterodimer consists of ADAT3 and ADAT2 and is involved in the adenosine-to-inosine conversion in tRNA. …”
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    A novel 8-bp duplication in ADAT3 causes mild intellectual disability
  8. 8
    “…Adenosine deaminase acting on transfer RNA (ADAT) is an essential eukaryotic enzyme that catalyzes the deamination of adenosine to inosine at the first position of tRNA anticodons. …”
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    tRNA deamination by ADAT requires substrate-specific recognition mechanisms and can be inhibited by tRFs
  9. 9
    “…Here, using cryo-EM, we present the structure of a eukaryotic ADAT2/3 deaminase bound to a full-length tRNA, revealing that the enzyme distorts the anticodon loop, but in contrast to the bacterial enzymes, selects its substrate via sequence-independent contacts of eukaryote-acquired flexible or intrinsically unfolded motifs distal from the conserved catalytic core. …”
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    Structural basis for sequence-independent substrate selection by eukaryotic wobble base tRNA deaminase ADAT2/3
  10. 10
    por González Dorantes, Edgar Adat
    Publicado 2009
    Tesis Libro
    Sistema de control personal de tiempos y defectos en el dasarrollo de software
  11. 11
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    Bibliometric and thematic analysis of articles in the field of infertility (2011-2015)
  12. 12
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    Complete Genome Sequence of Bacillus amyloliquefaciens Bacteriophage Ray17
  13. 13
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    Mothers’ views about sexual health education for their adolescent daughters: a qualitative study
  14. 14
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    Hepatitis Monthly, an International Journal in the Field of Hepatology
  15. 15
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    PIK3CA mutations in plasma circulating tumor DNA predict survival and treatment outcomes in patients with advanced cancers
  16. 16
    “…The formation of inosine at the wobble position of eukaryotic tRNAs is an essential modification catalyzed by the ADAT2/ADAT3 complex. In humans, a valine-to-methionine mutation (V144M) in ADAT3 that originated ∼1,600 years ago is the most common cause of autosomal recessive intellectual disability (ID) in Arabia. …”
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    Formation of tRNA Wobble Inosine in Humans Is Disrupted by a Millennia-Old Mutation Causing Intellectual Disability
  17. 17
    “…We show that amphioxus (Branchiostoma japonicum) ADAT2 (BjADAT2) contains the active site ‘HxE-PCxxC’ and the key residues for target-base-binding, and amphioxus ADAT3 (BjADAT3) harbors both the N-terminal positively charged region and the C-terminal pseudo-catalytic domain important for recognition of substrates. …”
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    Amphioxus adenosine-to-inosine tRNA-editing enzyme that can perform C-to-U and A-to-I deamination of DNA
  18. 18
    “…In humans, the wobble inosine modification is catalyzed by the heterodimeric ADAT2/3 complex. Here, we describe novel pathogenic ADAT3 variants impairing adenosine deaminase activity through a distinct mechanism that can be corrected through expression of the heterodimeric ADAT2 subunit. …”
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    Identification and rescue of a tRNA wobble inosine deficiency causing intellectual disability disorder
  19. 19
    “…In eukarya, wobble inosine modification is catalyzed by the heterodimeric ADAT complex containing ADAT2 and ADAT3. Human individuals homozygous for loss of function variants in ADAT3 exhibit intellectual disability disorders. …”
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    ADATscan – A flexible tool for scanning exomes for wobble inosine-dependent codons reveals a neurological bias for genes enriched in such codons in humans and mice
  20. 20
    “…The modification in eukaryotes results from a deamination reaction of adenine that is catalyzed by the heterodimeric enzyme adenosine deaminase acting on tRNA (hetADAT), composed of two subunits: ADAT2 and ADAT3. …”
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    Inosine modifications in human tRNAs are incorporated at the precursor tRNA level
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