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821por Luo, Lidan, Wang, Shuai, Chen, Bohao, Zhong, Mei, Du, Ruili, Wei, ChunShan, Huang, Furong, Kou, Xinhui, Xing, Yufeng, Tong, Guangdong“…BALB/c mice were intraperitoneally (i.p.) administered LPS/D-GalN to establish an ALF mouse model. HMGB1-A box was administered (i.p.) 1 h before establishing the ALF mouse model. …”
Publicado 2022
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822por Zhang, Danmei, Shi, Chunxia, Zhang, Qingqi, Wang, Yukun, Guo, Jin, Gong, Zuojiong“…BACKGROUND: Acute liver failure (ALF) is one of the most common life-threatening diseases in adults without previous liver disease. …”
Publicado 2023
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823por Zurera-Egea, Coral, Teniente-Serra, Aina, Fuster, Daniel, Martínez-Cáceres, Eva, Muga, Roberto, Zuluaga, Paola“…Activated Tregs (39.9 ± 11.5 vs. 32.4 ± 9.2, p = 0.06) showed a tendency to be higher in patients with ALF. The proportion of activated CD4(+) cells (r = 0.40, p < 0.01) and activated CD8(+) cells (r = 0.51, p < 0.01) was correlated with the proportion of NKT-like in patients without ALF. …”
Publicado 2023
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824“…BACKGROUND: Acute liver failure (ALF) and acute-on-chronic liver (ACLF) carry high short-term mortality rate, and may result from a wide variety of causes. …”
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825por Goggi, Julian L, Hartimath, Siddesh V, Xuan, Tan Yun, Khanapur, Shivashankar, Jieu, Beverly, Chin, Hui Xian, Ramasamy, Boominathan, Cheng, Peter, Rong, Tang Jun, Fong, Yong Fui, Yuen, Tsz Ying, Msallam, Rasha, Chacko, Ann-Marie, Renia, Laurent, Johannes, Charles, Hwang, You Yi, Robins, Edward G“…In this study, we explored granzyme B (GZB), released by tumor-associated immune cells, as a PET imaging-based stratification marker for successful combination therapy using a fluorine-18 ((18)F)-labelled GZB peptide ([(18)F]AlF-mNOTA-GZP). METHODS: Using the immunocompetent CT26 syngeneic mouse model of colon cancer, we assessed the potential for [(18)F]AlF-mNOTA-GZP to stratify OXA/5-FU and ICI combination therapy response via GZB PET. …”
Publicado 2021
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826por González-Ponce, Herson Antonio, Martínez-Saldaña, María Consolación, Rincón-Sánchez, Ana Rosa, Sumaya-Martínez, María Teresa, Buist-Homan, Manon, Faber, Klaas Nico, Moshage, Han, Jaramillo-Juárez, Fernando“…Acetaminophen (APAP)-induced acute liver failure (ALF) is a serious health problem in developed countries. …”
Publicado 2016
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827“…CONCLUSIONS: Reports of adult patients with ALF caused by HLH have increased, and HLH should be suspected in patients with ALF of indeterminate cause. …”
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828por Verloh, Niklas, Utpatel, Kirsten, Haimerl, Michael, Zeman, Florian, Fellner, Claudia, Dahlke, Marc, Renner, Philipp, Seyfried, Timo, Müller, Martina, Stroszczynski, Christian, Evert, Matthias, Wiggermann, Philipp“…RESULTS: The corresponding ADC values for the individual patient groups were as follows: NLF: 1123 (SD 95.8); MLF: 1032 (SD 77.6); ALF: 962 (SD 68.8); LC: 1015 (SD 60.2) mm2/s. There is a significant difference between NLF and MLF (p = 0.004) and between MLF and ALF (p = 0.022). …”
Publicado 2018
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829“…The aim of this study was to determine meat quality characteristics and fatty acid composition of Korean native black goats (KNBG) finished on intensive feeding of alfalfa (ALF) and conventional feeding of commercial concentrate pellets (CCP) with low-energy common grasses. …”
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830“…The activation energy of the electrical conductivity of the NaF-AlF(3)-CaF(2)-Al(2)O(3) melts was estimated. The activation energy of electrical conductivity for molten NaF-AlF(3) mixtures with CR 3.0 and 2.1, determined by the most mobile cations Na(+), increased from 15.8 kJ/mol up to 18.5 kJ/mol. …”
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831“…The AlF(3)- and LaF(3)-coated films exhibited a higher rate capability, cyclic performance, and stability at high temperature than the pristine film. …”
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832“…Brain edema in acute liver failure (ALF) remains lethal. Cytotoxic mechanisms associated with brain edema have been well recognized, but the role of vasogenic mechanisms of brain edema has not been explored. …”
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833por Warrillow, Stephen, Fisher, Caleb, Tibballs, Heath, Bailey, Michael, McArthur, Colin, Lawson-Smith, Pia, Prasad, Bheemasenachar, Anstey, Matthew, Venkatesh, Bala, Dashwood, Gemma, Walsham, James, Holt, Andrew, Wiersema, Ubbo, Gattas, David, Zoeller, Matthew, Álvarez, Mercedes García, Bellomo, Rinaldo“…Objective: Hyperammonaemia contributes to complications in acute liver failure (ALF) and may be treated with continuous renal replacement therapy (CRRT), but current practice is poorly understood. …”
Publicado 2023
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834por Jiao, M, Ren, F, Zhou, L, Zhang, X, Zhang, L, Wen, T, Wei, L, Wang, X, Shi, H, Bai, L, Zhang, X, Zheng, S, Zhang, J, Chen, Y, Han, Y, Zhao, C, Duan, Z“…In both the mouse model and human ALF subjects, PPARα was significantly downregulated in the injured liver. …”
Publicado 2014
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835por Guo, Enshuang, Li, Renlong, Yang, Jiankun, Zhang, Jun, Li, Anyi, Yang, Yan, Liu, Shenpei, Liu, Anding, Jiang, Xiaojing“…FK866 exhibits a protective effect on D-galactosamine (GaIN)/lipopolysaccharide (LPS) and concanavalin A (ConA)-induced acute liver failure (ALF), but the mechanism by which FK866 affords this benefit has not yet been elucidated. …”
Publicado 2017
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836por Zeng, Hui, Lin, Hui, Liu, Wenyi, Wang, Jia, Wang, Lingqiao, Zheng, Chuanfen, Tan, Yao, Huang, Yujing, He, Lixiong, Luo, Jiaohua, Pu, Chaowen, Zhang, Renping, Yang, Xiaohong, Tian, Yingqiao, Qiu, Zhiqun, Chen, Ji-an, Luo, Yang, Feng, Xiaobin, Xiao, Guosheng, Wu, Liping, Shu, Weiqun“…Abnormal liver function (ALF) plays a key role in metabolic syndrome (MetS), but only few data on the relationship between MetS and the risk factors for ALF (e.g., biotoxins) are available. …”
Publicado 2017
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837“…Parathyroid hormone levels were suppressed by ALF and plain vitamin D3 but were sustained in the ELD and control groups. …”
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838por Poschenrieder, Andreas, Osl, Theresa, Schottelius, Margret, Hoffmann, Frauke, Wirtz, Martina, Schwaiger, Markus, Wester, Hans-Jürgen“…Compared with [(nat)Ga]pentixafor, [(nat)F]AlF-NOTA-pentixather showed 1.4-fold higher CXCR4 affinity. [(18)F]AlF-NOTA-pentixather displayed high and CXCR4-specific in vivo uptake in Daudi xenografts (13.9% ± 0.8% injected dose per gram [ID/g] at 1 hour post injection [p.i.]). …”
Publicado 2016
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839por Lai, Wei-Yun, Wang, Jen-Wei, Huang, Bo-Tsang, Lin, Emily Pei-Ying, Yang, Pan-Chyr“…The TNF-α pathway is commonly upregulated in acute lung injury (ALI) and acute liver failure (ALF). Previous studies investigated the feasibility of adopting protein-based TNF-α blockers as disease modifiers in ALI and ALF, but none of these came out with a positive result. …”
Publicado 2019
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840por Hyun, Jeongeun, Oh, Seh-Hoon, Premont, Richard T, Guy, Cynthia D, Berg, Carl L, Diehl, Anna Mae“…OBJECTIVE: Uncertainty about acute liver failure (ALF) pathogenesis limits therapy. We postulate that ALF results from excessive reactivation of a fetal liver programme that is induced in hepatocytes when acutely injured livers regenerate. …”
Publicado 2019
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