“…Although PET imaging of antibodies is a relatively recent tool, applications with (89)Zr, (64)Cu, and (68)Ga have greatly increased in recent years, especially in the clinical setting, while other less common radionuclides such as (52)Mn, (86)Y, (66)Ga, and (44)Sc, but also (18)F as in [(18)F]AlF are emerging promising candidates for the radiolabeling of antibodies. …”
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“…It was proposed that removal of AlF(3) from the surface of the etched particles was significantly promoted and the hydrogen bonds between the terminations of two different adjacent layers were broken by the acoustic cavitation effect of ultrasound.…”
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“…We evidenced an increase in insulin sensitivity during an oral glucose tolerance test in ALF-5755 treated mice vs controls and decreased the pro-inflammatory cytokine C-X-C Motif Chemokine Ligand 5 (CXCL5). …”
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“…Furthermore, silencing of PvNLRP3-like followed by V. parahaemolyticus stimulation negatively regulated the transcripts of antimicrobial peptides (AMPs) including Lysozyme (LYZ) 3, Crustin (CRU) 2, Anti-lipopolysaccharide factor (ALF) 2/3 and Penaeidins (PEN) 3/4. This study enriches our current knowledge on shrimp innate immunity, and provides novel perspective to understand the immune regulation role of PvNLRP3-like.…”
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“…In terms of infrastructure, only 3/10 (30%) have adequate water supply, and alf (5/10) have telephone access in their ED. The qualitative resultshowedthat the most common barriers to emergency care delivery were prolonged patient stays in the emergency room, inadequate equipment, and a shortage of trained professionals. …”
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“…It is discovered that the principal evaporating substances are CaF(2), KF, and NaF, while the evaporation of MgF(2), AlF(3), and AlOF is less. KF evaporates absolutely in the early stage of the reaction, and CaF(2) evaporates in a large proportion during the late reaction period. …”
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“…Particularly, anti-LPS factors (ALFs) are promising LPS-sequestrating molecules. …”
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“…Further functional studies revealed that LvCD14L could bind to microorganisms’ PAMPs, showed interaction with LvToll1 and LvToll2, and regulated the expression of LvDorsal and LvALF2 in hemocytes. These results suggest that LvCD14L functions as a pattern recognition receptor and activates the NF-κB pathway through interaction with LvTolls. …”
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“…On the other hand, the kinetic inertness of the complexes, determined by following the Cu(2+)-mediated transmetallation reactions in the 7.5–10.5 pH range, resulted in a spontaneous and hydroxide-assisted dissociation slightly faster for [Al(AMPTA)] than for the other two complexes (t(1/2) = 4.5 h for [Al(AMPTA)], 12.4 h for [Al(AMPDA-HB)], and 24.1 h for [Al(CD3A-Bn)] at pH 7.4 and 25 °C). Finally, the [AlF](2+) ternary complexes were prepared and their stability in reconstituted human serum was determined by (19)F NMR experiments.…”
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“…Acute liver injury (ALI) in children, which commonly leads to acute liver failure (ALF) with the need for liver transplantation, is a devastating life-threatening condition. …”
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“…FUNDING: 10.13039/501100004359Swedish Research Council (2019-01676), LUA/ALF (723941) from the 10.13039/501100005754Sahlgrenska University Hospital and the Swedish brain foundation.…”
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“…The patient responded to antacid medication while experiencing intermittent, recurring bouts of ZES. 18F-AlF-NOTA-octreotide positron emission tomography (18F-OC PET)/computed tomography (CT) helped locate the tumor. …”
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“…The flagellar membrane adenylate cyclase is preferentially stimulated by Mn++, unresponsive to NaF, GTP, GTP gamma S, AlF4-, and forskolin, and is inhibited by trifluoperazine. …”
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“…Transport via the regulated pathway, as assayed by the release of secretogranin II (SgII) labeled in the TGN, was inhibited by depletion of ATP, or by the inclusion of 100 microM GTP gamma S, 50 microM AlF3-5 or 5 micrograms/ml BFA. When added after immature granules had formed, GTP gamma S stimulated rather than inhibited exocytosis. …”
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“…The two populations were also pharmacologically distinct, with AlF(4) selectively blocking export of transferrin receptor from recycling endosomes to the basolateral plasma membrane. …”
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“…All of these effects observed with GTP gamma S in semipermeable cells could be reproduced in intact cells treated with AlF4-. These results suggest that guanine nucleotides regulate the dynamic association/dissociation of the 110-kD protein with the Golgi apparatus and that BFA perturbs this process by interfering with the association of the 110-kD protein with the Golgi apparatus.…”
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“…A pair of CAPS oligonucleotides was developed by amplifying a 0.55-kb DNA fragment that exhibited species-specific digestion patterns with restriction enzymes Alf III and Nde I. Consistent results were obtained with all the four markers on all tested Boehmeria lines. …”
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“…Availability: The software is part of the open-source C++ library SeqAn (www.seqan.de) and a compiled version can be downloaded at http://www.seqan.de/projects/alf.html Contact: goeke@molgen.mpg.de; vingron@molgen.mpg.de Supplementary information: Supplementary data are available at Bioinformatics online.…”
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“…The ASP-PCR technique was used to evaluate the L858R substitutions in exon 21, and the results were analyzed using ALF Express II sequencer. In the adenocarcinoma metastases to bone obtained from 8 patients, deletions in exon 19 of the EGFR gene were revealed in 3 smoking men and one non-smoking woman, while L858R substitution in exon 21 was found in one smoking woman and one man of unknown smoking status. …”
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“…Although the azimuthal position of the A domain of the (SCH)E2·MgF state is similar to that in the E2·AlF (aluminum fluoride) state, in which the transmembrane luminal gate is closed, the arrangement of transmembrane helices in the (SCH)E2·MgF state shows a luminal-open conformation imposed on by bound SCH28080 at its luminal cavity, based on observations of the structure in the SCH28080-bound E2·BeF (beryllium fluoride) state. …”
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