“…A novel (18)F labeled radiotracer, (18)F-bivalent-IA, was developed via one step (18)F–AlF/NODA chelation reaction in aqueous phase with high radiochemical yield (65–75%, decay corrected) and good specific activity (750–850 mCi/μmol). …”
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“…BACKGROUND: Previous studies have confirmed that serum concentrations of actin-free Gc globulin (Af-Gc globulin) may provide prognostic information in patients withacute liver failure (ALF). However, until now the relation between plasma Af-Gc globulin levels and chronic or acute-on-chronic liver failure (CLF or ACLF) caused by HBV is unknown. …”
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“…The first liver transplantation (LT) was performed by Thomas E Starzl five decades ago, and yet it remains the only therapeutic option offering gold standard treatment for end-stage liver disease (ESLD) and acute liver failure (ALF) and certain early-stage liver tumors. Post-liver transplantation survival has also dramatically improved over the last few decades despite increasing donor and recipient age and more frequent use of marginal organs to overcome the organ shortage. …”
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“…The study population comprises patients with collagen-vascular disease-associated lung fibrosis (CVD-LF), fibrotic non-specific interstitial pneumonia (fNSIP), chronic hypersensitivity pneumonitis (cHP), and asbestos-related lung fibrosis (ALF). Disease progression needs to be proven by slope calculation of at least three Forced Vital Capacity (FVC) values obtained within 6–24 months prior to inclusion, documenting an annualized decline in percent predicted FVC of 5% (absolute) or more despite appropriate conventional therapy. …”
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“…RS also increased the activity of digestive enzymes (AMS, LPS, Tryp, and Pep) and immune enzymes (PO, T-AOC, T-NOS, and NO), and the expression levels of immune-related genes (proPO, ALF, Lys, HSP70, Trx, Muc-1, Muc-2, Muc-5AC, Muc-5B, and Muc-19). …”
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“…FUNDING: Swedish National Research Council Medicine and Stockholm County Council ALF-project grant (LE), and the Australian National Health and Medical Research Council (PM).…”
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“…Methods: Protein compositions obtained from MSCs cultured under hypoxic (10% O(2) hc-MSC) and normal (21% O(2) nc-MSC) conditions were used to treat acute liver failure (ALF) induced in mice by acetaminophen injection. …”
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“…BACKGROUND: Extracorporeal liver support therapies (ELS) are technical options (for bridge-to-recovery as well as bridge-to-transplant) in patients with acute liver dysfunction (e.g. acute liver failure (ALF), acute-on chronic liver failure (AoCLF) or decompensated chronic liver disease (decomp. …”
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“…Limited studies have reported on in-vitro analysis of PM(2.5) but as far as the authors are aware, bioaccessibility of PM(2.5) in artificial lysosomal fluid (ALF) has not been linked to urban development models before. …”
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“…Furthermore, a functional analysis showed that ocu-miR-155-5p, ocu-miR-16b-5p, and ocu-miR-122-5p can regulate the expression of genes involved in processes correlated with acute liver failure (ALF) in rabbits. Search tool for the retrieval of interacting genes/proteins (STRING) analysis showed that the potential target genes of the three selected miRNAs may interact with each other in different pathways. …”
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“…Knockdown of LvGSK3β by RNAi resulted in increases in the expression of LvDorsal and several NF-κB driven antimicrobial peptide (AMP) genes (including ALF, PEN and crustin), but a decrease in LvCactus expression. …”
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“…This should be considered when designing services aiming at minimizing long-term disability. FUNDING: ALF grant and Region Östergötland.…”
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“…Meanwhile, the clinical (18)F-AlF-NOTA-PRGD2 probe molecule was utilized to visualize and further confirmed the IgA nephropathy in vivo via positron emission computed tomography. …”
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“…The liver capacity to recover from acute liver injury is a critical factor in the development of acute liver failure (ALF) caused by viral infections, ischemia/reperfusion or drug toxicity. …”
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“…Aging disrupts the maintenance of liver homeostasis, which impairs hepatocyte regeneration and aggravates acute liver injury (ALI), ultimately leading to the development of acute liver failure (ALF), a systemic inflammatory response, and even death. …”
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“…A 1.8 Å structure of a Duf8901-(Asp248)–AlF(4)–OH(2)•Co(2+) transition-state mimetic suggests an associative mechanism in which Asp195 and Asp363 orient and activate the water nucleophile. …”
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“…The liposome formulation ALF55, with identical lipid composition but lacking QS-21 had no effect. …”
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“…These findings provide novel insights into the mechanisms whereby this compound acts as an anti-inflammatory agent and highlight the potential application of FLD in the treatment of acute liver failure (ALF).…”
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“…FUNDING: Swedish Heart-Lung Foundation, Swedish Research Council, ALF grant from the Sahlgrenska University Hospital, Novo Nordisk Foundation, Sigrid Juselius Foundation, Helsinki University Hospital Government Research funds, Finnish Heart Foundation, and Finnish Diabetes Research Foundation.…”
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“…FUNDING: 10.13039/501100004359Swedish Research Council, Allmänna Sjukhusets i Malmö Stiftelsen för bekämpande av cancer, 10.13039/501100003793Swedish Heart-Lung Foundation, ALF funding from Region Skåne and 10.13039/501100004543China Scholarship Council.…”
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