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1501rRNA methylation by Spb1 regulates the GTPase activity of Nog2 during 60S ribosomal subunit assembly“…Here, we present cryo-EM reconstructions that reveal that unmethylated G2922 leads to the premature activation of Nog2 GTPase activity and capture a Nog2-GDP-AlF(4)(−) transition state structure that implicates the direct involvement of unmodified G2922 in Nog2 GTPase activation. …”
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1502por Seo, Ji-In, Nishigori, Chikako, Ahn, Jung Jin, Ryu, Jae Young, Lee, Junglok, Lee, Mu-Hyoung, Kim, Su Kang, Jeong, Ki-Heon“…The remaining four variants were found in non-XP genes, including one frameshift variant [rs72452004 of olfactory receptor family 2 subfamily T member 35 (OR2T35)], three missense variants [rs202089462 of ALF transcription elongation factor 3 (AFF3), rs138027161 of TCR gamma alternate reading frame protein (TARP), and rs3750575 of annexin A7 (ANXA7)]. …”
Publicado 2023
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1503por Sharma, Gitanjali, Braga, Marta C., Da Pieve, Chiara, Szopa, Wojciech, Starzetz, Tatjana, Plate, Karl H., Kaspera, Wojciech, Kramer-Marek, Gabriela“…In vivo imaging demonstrated that (18)F-AlF-NOTA-Z(PD-L1) can distinguish between PD-L1 high-expressing tumours (U87-MGvIII) and PD-L1-negative ones (H292(PD-L1Ko)). …”
Publicado 2023
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1504por Lundgren, Pia, Jacobson, Lena, Gränse, Lotta, Hård, Anna-Lena, Sävman, Karin, Hansen-Pupp, Ingrid, Ley, David, Nilsson, Anders K., Pivodic, Aldina, Smith, Lois E., Hellström, Ann“…FUNDING: The 10.13039/501100006310Swedish Medical Research Council #2020-01092, The 10.13039/501100005689Gothenburg Medical Society, Government grants under the ALF agreement ALFGBG-717971 and ALFGBG-971188, 10.13039/501100011831De Blindas Vänner, 10.13039/501100004063Knut and Alice Wallenberg Foundation - Wallenberg Clinical Scholars, 10.13039/100000002NIHEY017017, EY03090410.13039/100006823BCH10.13039/100007857IDDRC (1U54HD090255 Massachusetts Lions Eye Foundation) supported the study.…”
Publicado 2023
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1505por Ning, Jinrong, Zheng, Guodong, Cai, Yi, Hu, Yunguang, Liu, Yiqi, Lai, Enping, Chen, Baizhong, Liu, Yujie, Liang, Ziqi, Fu, Jijun, Wei, Minyan“…PURPOSE: APAP-induced liver injury (AILI) is a common cause of acute liver failure (ALF). Nobiletin (NOB) is a potential hepatoprotective agent for the treatment of APAP-induced liver injury. …”
Publicado 2023
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1506por Schwer, Beate, Ghosh, Agnidipta, Sanchez, Ana M., Lima, Christopher D., Shuman, Stewart“…Finally, we report a new 1.45 Å crystal structure of SpFcp1 with Mg(2+) and AlF(3) that mimics an associative phosphorane transition state of the enzyme-aspartyl-phosphate hydrolysis reaction.…”
Publicado 2015
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1507por Usachov, Valentyn, Urban, Thomas J., Fontana, Robert J., Gross, Annika, Iyer, Sapna, Omary, M. Bishr, Strnad, Pavel“…BACKGROUND: Keratin 8 and 18 (K8/K18) cytoskeletal proteins protect hepatocytes from undergoing apoptosis and their mutations predispose to adverse outcomes in acute liver failure (ALF). All known K8/K18 variants occur at relatively non-conserved residues and do not cause keratin cytoskeleton reorganization, whereas epidermal keratin-conserved residue mutations disrupt the keratin cytoskeleton and cause severe skin disease. …”
Publicado 2015
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1508por Olmo, Rocío, Cabrera, Javier, Moreno-Risueno, Miguel A., Fukaki, Hidehiro, Fenoll, Carmen, Escobar, Carolina“…Moreover, RKNs induce the ectopic development of roots from leaf and root-galls, also formed in mutants compromised in LR formation, arf7/arf19, slr, and alf4. Therefore, nematodes must target molecular signatures to induce post-embryogenic de novo organogenesis through the LBD16 callus formation pathway partially different from those prevalent during normal LR development.…”
Publicado 2017
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1509por Patterson, Jenna, Hussey, Hannah Sophia, Silal, Sheetal, Goddard, Liz, Setshedi, Mashiko, Spearman, Wendy, Hussey, Gregory D, Kagina, Benjamin M, Muloiwa, Rudzani“…It is important to understand the epidemiology of viral-induced ALF to plan for clinical case management and case prevention. …”
Publicado 2020
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1510por Li, Li, Zhao, Wei, Sun, Xiaorong, Liu, Ning, Zhou, Yue, Luan, Xiaohui, Gao, Song, Zhao, Shuqiang, Yu, Jinming, Yuan, Shuanghu“…BACKGROUND: The objective of this study was to explore the benefit of (18)F-AlF-NOTA-PRGD2 positron emission tomography/computed tomography (denoted as (18)F-RGD PET/CT) imaging for determining the clinical pathologic features of non-small cell lung cancer (NSCLC). …”
Publicado 2020
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1511“…STUDY FUNDING/COMPETING INTEREST(S): The study was financed by grants from the Swedish state under the agreement between the Swedish government and the county councils, the ALF-agreement (ALFGBG-70940). It was also financed by the Local Research and Development Board for Gothenburg and Södra Bohuslän (VGFOUGSB-866771) and by Hjalmar Svensson’s research foundation (HJSV-2017012). …”
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1512por Yin, Hua-Feng, Yin, Chun-Ming, Ouyang, Ting, Sun, Shu-Ding, Chen, Wei-Guo, Yang, Xiao-Lin, He, Xin, Zhang, Chun-Feng“…RESULTS: The optimized nanoemulsion formula (OF) consists of Maisine CC, Labrasol ALF and Transcutol HP in a weight ratio of 20:60:20 (w/w/w), in which ratio the OF shows multiple improvements, specifically small mean droplet size, excellent stability, fast release properties as well as enhanced solubility and permeability. …”
Publicado 2021
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1513por Liu, Jie, Wu, Leilei, Liu, Zhiguo, Seery, Samuel, Li, Jianing, Gao, Zhenhua, Yu, Jinming, Meng, Xue“…BACKGROUND: The aim of this study was to evaluate (18)F-AlF-NOTA-PRGD2 positron emission tomography/computed tomography ((18)F-RGD PET/CT) and serum inflammation biomarkers for predicting outcomes of patients receiving combined antiangiogenic treatment for advanced non-small cell lung cancer (NSCLC). …”
Publicado 2021
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1514por Spetz, Malin, Lundberg, Lisa, Nwaru, Chioma, Li, Huiqi, Santosa, Ailiana, Leach, Susannah, Gisslén, Magnus, Hammar, Niklas, Rosvall, Maria, Nyberg, Fredrik“…FUNDING: SciLifeLab / Knut & Alice Wallenberg Foundation, Swedish Research Council, Swedish government ALF-agreement, FORMAS.…”
Publicado 2022
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1515por Jarman, Angela F., Ford, James S., Maynard, Matthew J., Simmons, Zena L., Mackey, Kevin E., Mumma, Bryn E., Rose, John S.“…Sacramento County (California USA) has used a novel Mobile Integrated Health Unit (MIH) to test hundreds of patients who dwell in congregate living facilities, including skilled nursing facilities (SNF), residential care facilities (ie, assisted living facilities [ALF] and board and care facilities [BCF]), and inpatient psychiatric facilities (PSY), for SARS-CoV-2. …”
Publicado 2022
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1516por Khsiba, Amal, Bradai, Samir, Mahmoudi, Moufida, Mohamed, Asma Ben, Medhioub, Mouna, Hamzaoui, Lamine, Azouz, Mohamed Mousadek“…An important prognostic factor in SALI is the development of hepatic encephalopathy (HE) and thus its progression to acute liver failure (ALF), formerly known as acute severe hepatitis. …”
Publicado 2022
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1517“…Leading indications for LT were decompensated liver disease (61.5%), acute-on-chronic liver failure (23.1%), acute liver failure (ALF) (7.7%), and recurrent cholangitis and growth failure (7.7%). …”
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1518por Yu, Zhebin, Ekström, Sandra, Bellander, Tom, Ljungman, Petter, Pershagen, Göran, Eneroth, Kristina, Kull, Inger, Bergström, Anna, Georgelis, Antonios, Stafoggia, Massimo, Gruzieva, Olena, Melén, Erik“…FUNDING: The study received funding from the 10.13039/501100004359Swedish Research Council (grant no. 2020-01886, 2022-06340), the 10.13039/501100004359Swedish Research Council for Health, Working life and Welfare (FORTE grant no. 2017-01146), the 10.13039/501100003793Swedish Heart-Lung Foundation, 10.13039/501100004047Karolinska Institute (no. 2022-01807) and Region Stockholm (ALF project for cohort and database maintenance).…”
Publicado 2023
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1519por Charitakis, E, Valera Soria, C, Almroth, H, Karlsson, L, Guidi, C, Sandgren, E, Liuba, I, Balata, D, Hassel Jonsson, A, Walfridsson, H, Walfridsson, U“…Main funding source(s): ALF grants (County Council of Östergotland). BACKGROUND: Ventricular tachycardia (VT) is a significant cause of morbidity and mortality (1). …”
Publicado 2023
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1520“…The study was financed by Swedish governmental funding of clinical research (ALF). Trial registration number: ISRCTN10940791. …”
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