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7561“…The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has arisen as a global pandemic affecting the respiratory system showing acute respiratory distress syndrome (ARDS). However, there is no targeted therapeutic agent yet and due to the growing cases of infections and the rising death tolls, discovery of the possible drug is the need of the hour. …”
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7562por Velavan, Thirumalaisamy P., Pallerla, Srinivas Reddy, Rüter, Jule, Augustin, Yolanda, Kremsner, Peter G., Krishna, Sanjeev, Meyer, Christian G.“…SARS-CoV-2 infections range from asymptomatic to severe courses of COVID-19 with acute respiratory distress syndrome (ARDS), multiorgan involvement and death. Risk factors for disease severity include older age, male sex, increased BMI and pre-existing comorbidities. …”
Publicado 2021
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7563“…It involves activation of multiple inflammatory pathways leading to hyperinflammation and cytokine storm, resulting in tissue damage, acute respiratory distress syndrome (ARDS) and multi-organ failure. Accumulating evidence has raised concern over the long-term health effects of COVID-19. …”
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7564por Alayash, Abdu I.“…The novel coronavirus (2019-nCoV/SARS-CoV-2) causes respiratory symptoms including a substantial pulmonary dysfunction with worsening arterial hypoxemia (low blood oxygenation), eventually leading to acute respiratory distress syndrome (ARDS). The impact of the viral infection on blood oxygenation and other elements of oxygen homeostasis, such as oxygen sensing and respiratory mitochondrial mechanisms, are not well understood. …”
Publicado 2021
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7565por Ierardi, Anna Maria, Coppola, Andrea, Tortora, Silvia, Valconi, Elena, Piacentino, Filippo, Fontana, Federico, Stellato, Elvira, Cogliati, Chiara Beatrice, Torzillo, Daniela, Giampalma, Emanuela, Renzulli, Matteo, Bargellini, Irene, Cioni, Roberto, Scandiffio, Rossella, Spinazzola, Angelo, Foà, Riccardo Alessandro, Del Giudice, Costantino, Venturini, Massimo, Carrafiello, Gianpaolo“…Previous or actual COVID Acute respiratory distress syndrome (ARDS) and a high level of D-dimer were encountered in most cases. …”
Publicado 2021
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7566por Mahdavi, Mohammad, Hejri, Golnar Mortaz, Pouraliakbar, Hamidreza, Shahzadi, Hossein, Hesami, Mahshid, Houshmand, Golnaz“…Three days after transplant, he developed progressive acute respiratory distress syndrome (ARDS) with the rise of inflammatory markers. He unfortunately died after 20 days because of disseminated intravascular coagulation (DIC). …”
Publicado 2021
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7567por Shivshankar, Pooja, Karmouty-Quintana, Harry, Mills, Tingting, Doursout, Marie-Francoise, Wang, Yanyu, Czopik, Agnieszka K., Evans, Scott E., Eltzschig, Holger K., Yuan, Xiaoyi“…Immunopathogenesis of COVID-19 leads to acute respiratory distress syndrome (ARDS) and organ failure. Binding of SARS-CoV-2 spike protein to human angiotensin-converting enzyme 2 (hACE2) on bronchiolar and alveolar epithelial cells triggers host inflammatory pathways that lead to pathophysiological changes. …”
Publicado 2022
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7568por Farhangnia, Pooya, Dehrouyeh, Shiva, Safdarian, Amir Reza, Farahani, Soheila Vasheghani, Gorgani, Melika, Rezaei, Nima, Akbarpour, Mahzad, Delbandi, Ali-Akbar“…These approaches are based on reduced inflammation due to inhibiting cytokine storm phenomena, immunomodulation, preventing acute respiratory distress syndrome (ARDS), viral neutralization, and decreased viral load. …”
Publicado 2022
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7569por Miller, Andrew G., Tan, Herng Lee, Smith, Brian J., Rotta, Alexandre T., Lee, Jan Hau“…Following two large randomized controlled trials showing no benefit and harm, respectively, HFOV has largely been abandoned in adults with ARDS. A multi-center clinical trial in children is ongoing. …”
Publicado 2022
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7570“…SUMMARY: Finally, the best outcomes are likely achieved at centers with experience at severe ARDS management and protocols for escalation of care.…”
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7571“…Recent studies have indicated that the cytokine storm might play an essential role in the disease progression in patients with COVID-19, which is characterized by the uncontrolled release of cytokines and chemokines leading to acute respiratory distress syndrome (ARDS), multi-organ failure, and even death. Cell death, especially, inflammatory cell death, might be the initiation of a cytokine storm caused by SARS-CoV-2 infection. …”
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7572por Rarani, Fahimeh Zamani, Rashidi, Bahman, Jafari Najaf Abadi, Mohammad Hassan, Hamblin, Michael R., Reza Hashemian, Seyed Mohammad, Mirzaei, Hamed“…The cytokine storm is a hyperinflammatory medical condition due to excessive and uncontrolled release of pro-inflammatory cytokines in patients suffering from severe COVID-19, leading to the development of acute respiratory distress syndrome (ARDS) and multiple organ dysfunction syndrome (MODS) and even mortality. …”
Publicado 2022
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7573por Boland, Lauren, Bitterlich, Laura Melanie, Hogan, Andrew E., Ankrum, James A., English, Karen“…Mesenchymal stromal cell (MSC) therapy has seen increased attention as a possible option to treat a number of inflammatory conditions including COVID-19 acute respiratory distress syndrome (ARDS). As rates of obesity and metabolic disease continue to rise worldwide, increasing proportions of patients treated with MSC therapy will be living with obesity. …”
Publicado 2022
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7574por Balakrishna Pillai, Agieshkumar, Mariappan, Vignesh, JeanPierre, Aashika Raagavi, Rao, S. R.“…In this sense, mesenchymal stromal/stem cells (MSCs) has been emerging to be a promising therapeutic strategy in restoring endothelial barrier function in various lung disease, including ALI and ARDS. The mechanism of the role of MSCs in restoring endothelial integrity among single-strand RNA (ssRNA) viruses that target endothelial cells remains elusive. …”
Publicado 2022
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7575por Wang, Chaochao, Huyan, Ting, Zhou, Xiaojie, Zhang, Xuanshuo, Duan, Suyang, Gao, Shan, Jiang, Shanfeng, Li, Qi“…SARS-CoV-2 continuously mutates and evolves with a high basic reproduction number (R0), resulting in a variety of clinical manifestations ranging from asymptomatic infection to acute respiratory distress syndrome (ARDS) and even death. To gain a better understanding of coronavirus disease 2019 (COVID-19), it is critical to investigate the components that cause various clinical manifestations. …”
Publicado 2022
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7576por Nadeem, Rashid, Bon, Islam, Algohary, Doaa, Kafeel Khan, Mohd, Gundawar, Nilesh, Abdullah, Mohammed, Sharma, Ekta, Galal Elzeiny, Moatz, Mahmoud, Mayada, Elhoufi, Ashraf, Alshaikh Sayed Ahmed, Yusra Omar, Gheno, Gloria, Salama Khalil, Maged Talaat, Hussain, Tamseela“…The prescription of steroids in Covid-19 ARDS is variable. The dose of steroids impacts mortality rate and length of stay in ICU, although patients treated with high dose steroids seem to stay more days in ICU.…”
Publicado 2022
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7577por Rezaei, Mitra, Mohammadpour, Hadiseh, Eftekhari, Mahya, Pourabdollah, Mihan, Nasr Azadani, Farinaz, Tabarsi, Payam, Marjani, Majid, Ziai, Seyed Ali“…Numerous patients with no associated risk factors demonstrate acute respiratory distress syndrome (ARDS). The role of genetic factors in determining the severity and outcome of the disease remains unresolved. …”
Publicado 2022
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7578por Dutta, Saugata, Zhu, Yin, Han, Yohan, Almuntashiri, Sultan, Wang, Xiaoyun, Zhang, Duo“…Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), represent an acute stage of lung inflammation where the alveolar epithelium loses its functionality. …”
Publicado 2023
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7579por Li, Junfeng, Zhang, Jianfeng, Shi, Mingyu, Yu, Sifan, Ji, Mengjun, Liang, Yangfan, Meng, Xiangyan“…PBLI patients, characterized by diffused intra-alveolar destruction, including hemorrhage and inflammation, might deteriorate into acute respiratory distress syndrome (ARDS) with high mortality. However, due to the absence of guidelines about PBLI, emergency doctors and rescue teams treating PBLI patients rely on experience. …”
Publicado 2023
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7580por Sher, Emina Karahmet, Ćosović, Adnan, Džidić-Krivić, Amina, Farhat, Esma Karahmet, Pinjić, Emma, Sher, Farooq“…The main goal of this study is to investigate the complex inflammatory processes that occur in Covid-19 disease and to find similarities with other inflammatory diseases such as multiple sclerosis (MS), acute respiratory distress syndrome (ARDS), rheumatoid arthritis (RA) and Kawasaki syndrome to advance existing diagnostic and therapeutic protocols. …”
Publicado 2023
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