“…IGF activity maintains human lung homeostasis and is implicated in pulmonary diseases such as cancer, ARDS, COPD, asthma and fibrosis. Here we report that lung transcriptome analysis in mice with a postnatally-induced Igf1r gene deletion showed differentially expressed genes with potentially protective roles related to epigenetics, redox and oxidative stress. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The patient subsequently developed acute respiratory distress syndrome (ARDS) followed by rash and acute interstitial nephritis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Acute respiratory distress syndrome (ARDS) is a major cause of mortality in critically ill patients. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Seawater (SW) inhalation can induce acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). In the present study, SW induced apoptosis of rat alveolar epithelial cells and histopathological alterations to lung tissue. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Complications observed included hyperchloremia (35.94%), hypokalemia (30.81%), hyponatremia (26.70%), cerebral edema (16.43%), shock (13.35%), acute kidney injury (10.27%), arrhythmias (3.8%), and thrombotic thrombocytopenic purpura (5.4%), while one patient had myocarditis and ARDS each. 13/37 children (35%) needed inotropic support, 11/37 (30%) required mechanical ventilation while only one patient required renal replacement therapy. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: Adjusting the confounding factors, significant risk factors for IA were chronic obstructive pulmonary disease (COPD), temperature of ≥38°C, pneumonia and acute respiratory distress syndrome (ARDS). The best predictor of IA was AspICU algorithm (AUC, 1) followed by serum galactomannan antigen (GM) cut-off (≥1.24) calculated based on AspICU algorithm (AUC, 0.822). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…She needed immediate oxygen supply, while ABGs deteriorated and chest imaging and PaO(2)/FiO(2) indicated ARDS. Early administration of systemic corticosteroids led to gradual clinical improvement. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The maintenance of endothelial barrier integrity is absolutely essential to prevent the vascular leak associated with pneumonia, pulmonary edema resulting from inhalation of toxins, acute elevation to high altitude, traumatic and septic lung injury, acute lung injury (ALI), and its life-threatening complication, acute respiratory distress syndrome (ARDS). In addition to the long-known edemagenic and inflammatory agonists, emerging evidences suggest that factors of endothelial cell (EC) mechanical microenvironment such as blood flow, mechanical strain of the vessel, or extracellular matrix stiffness also play an essential role in the control of endothelial permeability and inflammation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Results indicate that at the same ventilation efficiency (same PaCO(2) level), we expect tidal volume dosage in the range of 7.4 mL/kg (for ASV), 6.2 mL/kg (for AVM2), and 6.7 mL/kg (for MFV) for adult ARDS simulation. For a neonatal RDS model, we expect 5.5 mL/kg (for ASV), 4.6 mL/kg (for AVM2), and 4.5 (for MFV). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: Although the peroxisome proliferator-activated receptor-γ (PPARγ) agonist rosiglitazone has significant anti-inflammatory properties, no scientific studies have provided new insights in its pharmacological properties with respect to acute respiratory distress syndrome (ARDS). The present investigation aimed to evaluate whether rosiglitazone can reduce apoptosis and inflammation in a lipopolysaccharide (LPS)-induced acute respiratory distress syndrome in vitro model. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In order to fulfill unmet needs of treating acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), APDs introduced in this work could be promising lead compounds to develop high potent anti-inflammation agents.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…To date, researchers have discovered that Nrf2 deletion results in high susceptibility and severity of insults in various models of respiratory diseases, including bronchopulmonary dysplasia (BPD), respiratory infections, acute respiratory distress syndrome (ARDS), chronic obstructive pulmonary disease (COPD), asthma, idiopathic pulmonary fibrosis (IPF), and lung cancer. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This included non-productive cough (14%), isolated productive cough (10%), productive cough with abnormal chest finding (16%), pneumonia (8%), pleural effusion (5%), ARDS (2%). Percentage predicted FEV1 and FVC were lower in participants with PPCs. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In addition, ELISA and Western blot results revealed that Phil inhibits the activation of the NF-κB and MAPK signaling pathways and decreases the levels of inflammatory cytokines (IL-1β, IL-6, and TNF-α) in LPS-induced ARDS mice. In general, protection against endothelial glycocalyx HS damage and inhibition of inflammatory responses by Phil may be used as treatment targets for LPS-induced AKI.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…However, numerous in vitro experiments have demonstrated that inadvertant release of highly reactive oxygen metabolites by the PMN into the surrounding milieu results in autoinjury and is associated with diffuse capillary leak syndromes (septic shock, ARDS). NADPH oxidoreductase, the superoxide anion generating enzyme, is a PMN membrane bound flavoprotein normally dormant but inducible by a variety of agents. …”
Enlace del recurso
Enlace del recurso

“…The follow-up with chest X-Rays and CT scans was also included, showing a progressive adult respiratory distress syndrome (ARDS). RESULTS: Moderate to severe progression of the lung infiltrates, with increasing percentage of high-density infiltrates sustained by a bilateral and multi-segmental extension of lung opacities, were seen. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Rituximab, for example, may cause serum sickness, vasculitis, cutaneous reactions, interstitial pneumonitis, and ARDS as well as post-infusion reactions. Some patients receiving cetuximab experienced severe immediate hypersensitivity reactions. …”
Enlace del recurso
Enlace del recurso

“…Although the most frequent cause of diffuse non-infectious parenchymal lung involvement is acute hydrostatic pulmonary edema, there is a wide variety of diseases that may be encountered, including acute drug toxicity, hypersensitivity pneumonitis (HP), acute respiratory distress syndrome (ARDS) and diffuse alveolar hemorrhage (DAH). In trauma patients, fat embolism syndrome (FES) must be taken into account. …”
Enlace del recurso
Enlace del recurso

“…The most important event is the increased sympathetic activity via the central stimulation, this activity increases pulmonary capillary leaking, causing the ARDS. As the cytosolic pH, which is already low in patients with diabetes will decrease further with the mechanisms mentioned above, the viral load will increase and the infection will be exacerbated. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In these severe cases, an exaggerated inflammatory response, known as “cytokine storm”, occurs which results in damage to the respiratory epithelial barrier and development of acute respiratory distress syndrome (ARDS). Data from retrospective human studies as well as experimental animal models of influenza virus infection highlight the fine line between an excessive and an inadequate immune response, where the host response must balance viral clearance with exuberant inflammation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso