“…BACKGROUND: Previous studies linked a high intensity of ventilation, measured as mechanical power, to mortality in patients suffering from “classic” ARDS. By contrast, mechanically ventilated patients with a diagnosis of COVID-19 may present with intact pulmonary mechanics while undergoing mechanical ventilation for longer periods of time. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The empirical treatment modalities were relegated to historical expertise from the traditional management of acute respiratory distress syndrome (ARDS) in conjunction with off-label pharmaceutical agents endorsed under the “emergency use authorization” (EUA) paradigm by regulatory agencies. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSIONS: A broad based lipidomic storm is a predictor of poor prognosis in ARDS. Alterations in sPLA2, PGD2 and 12‐HETE and the high abundance lipids, ChoE 18:3, LPC‐O‐16:0 and PC‐O‐30:0 exhibit relative specificity for COVID‐19 amongst such patients and correlate with the inflammatory response to link to disease severity.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: Twenty-seven (35.1%) patients developed CPB-ALI in the study, including eleven (14.3%) patients with ARDS. The earliest significant drop of pGSN and normalized pGSN (pGSN(N)) of ALI group both occurred at 6 hours after CPB (p = 0.04 and p < 0.01), which was much earlier than those of non-ALI group (48 hours, p = 0.03 and 24 hours, p < 0.01); PGSN of ALI group before CPB and 6 hours after CPB were both significantly lower than those of non-ALI group (p < 0.01); PGSN(N) of ALI group before CPB and 6 hours after CPB were both significantly lower than those of non-ALI group (p < 0.01, p = 0.04); PGSN before CPB was the only independent risk factor predicting the occurrence of CPB-ALI (OR, 1.023; 95% CI, 1.007-1.039; p < 0.01) with an AUC of 0.753 (95% CI, 0.626-0.880); The optimal cutoff value of pGSN before CPB was 264.2 mg/L, with a sensitivity of 58.3% and a specificity 94.7%. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Complications were more frequent in non-survivors: acute respiratory distress syndrome (ARDS) (95% vs. 89%; P=.009), acute kidney injury (AKI) (58% vs. 24%; P<10(-16)), shock (42% vs. 14%; P<10(-13)), and arrhythmias (24% vs. 11%; P<10(-4)). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Complications were more frequent in non-survivors: acute respiratory distress syndrome (ARDS) (95% vs 89%; p = 0.009), acute kidney injury (AKI) (58% vs 24%; p < 10(−16)), shock (42% vs 14%; p < 10(−13)), and arrhythmias (24% vs 11%; p < 10(−4)). …”
Enlace del recurso
Enlace del recurso

“…Acute respiratory distress syndrome (ARDS) developed in 140 (62.8%) patients, 23 (25.3%) of these patients survived. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The top features contributing most to the classification by the model (for each outcome) were the following: “appointments specialty,” “home health,” and “home care” (home); “intubate” and “ARDS” (inpatient rehabilitation); “service” (SNIF); “brief assessment” and “covid” (death). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: Coronavirus disease 2019 (COVID-19) is an infectious disease characterized by cough, fever, and fatigue and 20% of cases will develop into severe conditions resulting from acute lung injury with the manifestation of the acute respiratory distress syndrome (ARDS) that accounts for more than 50% of mortality. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Severe complications included septic shock (12/21, 57.14%), hemophagocytic lymphohistiocytosis (HLH) (11/21, 52.38%), acute respiratory distress syndrome (ARDS) (10/21, 47.62%), multiple organ dysfunction syndrome (MODS) (9/21, 42.86%), and disseminated intravascular coagulation (DIC) (7/21, 33.33%). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In the final logistic model, variables including aged 60 or older [odds ratio (OR) 1.826, 95% confidence interval (CI): 1.060–3.142], acute respiratory distress syndrome (ARDS) (OR 2.748, 95% CI: 1.051–7.185), lymphocytes count lower than 1.1×10(9)/L (OR 0.478, 95% CI: 0.240–0.949), level of interleukin-6 (IL-6) greater than 7 pg/mL (OR 1.664, 95% CI: 1.005–2.751) and D-Dimer greater than 0.5 μg/mL (OR 2.190, 95% CI: 1.176–4.084) were significantly associated with the extrapulmonary organ injury. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Majority of SARS-CoV2 positives (P) had ARDS (58.8%), required mechanical ventilation (73%), inotropic support (55%), therapeutic anticoagulation (28%), proning (35%), Rectal tube (43%), Tocilizumab (18%), and steroids (43%) (Table 2). …”
Enlace del recurso
Enlace del recurso

“…Majority of patients during COVID period had ARDS (39.6%), required mechanical ventilation (57%), inotropic support (46.2%), therapeutic anticoagulation (24.2%), proning (22%), rectal tube (28.6%), Tocilizumab (9.9%), and steroids (30.8%) in comparison to pre-COVID (Table 2). …”
Enlace del recurso
Enlace del recurso

“…Increased costs were associated with conditions such as diabetes (frequency 15.0%; 3.45-fold increase compared to those without diabetes), adiposity (3.3%; 2.09-fold increase) or immune disorders (5.6%; 1.88-fold increase) and with Influenza-associated complications such as Influenza pneumonia (24.3%; 1.95-fold), bacterial pneumonia (6.3%; 3.86-fold), ARDS (1.2%; 10.90-fold increase) or sepsis (2.3%; 8.30-fold). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…An acute respiratory distress syndrome (ARDS) model was used to study whether S1pr1 inhibition evoked greater inflammation in lungs. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Finally, those participants with OSA who develop ARDS reported an adjusted OR 20.4 (95%-CI, 1.04–504) risk of neurocognitive impairment. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…What predominates like other series were obesity, use of steroids, and ARDS. The contribution of small Mexican series like ours (based on the new guidelines) will allow to understand that CAPA could be no longer a rare fungal infectious disease complication in severely ill COVID-19 patients. …”
Enlace del recurso
Enlace del recurso

“…Alternative tests (e.g., rapid antigen tests) are also acceptable as laboratory confirmation if their specificity has been accepted by the Sponsor. 4. Moderate to severe ARDS (PaO2/FiO2 ratio equal or less than 200 mmHg) for less than 96 hours at the time of randomization. 5. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The most common immediate cause of death pertained to the respiratory system (ARDS, refractory hypoxia, respiratory) in more than half of the patients. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Repetative e sigh manouvers proved to be essential for arDS patients. They reopened collapsed alveolli and improved aeration of the lung which was confirmed by X ray and CT scan as an objective methods for verification of lung condition.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso