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9281por Tendulkar, Prakash, Pandey, Pragya, Panda, Prasan K, Bhadoria, Ajeet S, Kulshreshtha, Poorvi“…Complications manifested were acute respiratory distress syndrome (ARDS) in 78.3% [95% CI (74–82.1)] and shock in 54.7% [95% CI (49.8–59.5)]. …”
Publicado 2022
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9282por Maskin, Luis Patricio, Olarte, Gabriel Leonardo, Palizas, Fernando, Velo, Agostina E., Lurbet, María Fernanda, Bonelli, Ignacio, Baredes, Natalio D., Rodríguez, Pablo Oscar“…TRIAL REGISTRATION: The trial was registered under the title “Dexamethasone for COVID-19 Related ARDS: a Multicenter, Randomized Clinical Trial” with ClinicalTrials number NCT04395105, https://clinicaltrials.gov/ct2/show/NCT04395105, registered on 20 May 2020. …”
Publicado 2020
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9283“…CASE REPORT - DISCUSSION: The most common complication of COVID-19 is Acute Respiratory Distress Syndrome (ARDS) however several other serious complications have been identified including cardiac injury, thromboembolic events, neurological abnormalities, and an aggravated inflammatory response causing a cytokine storm. …”
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9284por Di Castelnuovo, Augusto, Bonaccio, Marialaura, Costanzo, Simona, Gialluisi, Alessandro, Antinori, Andrea, Berselli, Nausicaa, Blandi, Lorenzo, Bruno, Raffaele, Cauda, Roberto, Guaraldi, Giovanni, My, Ilaria, Menicanti, Lorenzo, Parruti, Giustino, Patti, Giuseppe, Perlini, Stefano, Santilli, Francesca, Signorelli, Carlo, Stefanini, Giulio G., Vergori, Alessandra, Abdeddaim, Amina, Ageno, Walter, Agodi, Antonella, Agostoni, Piergiuseppe, Aiello, Luca, Al Moghazi, Samir, Aucella, Filippo, Barbieri, Greta, Bartoloni, Alessandro, Bologna, Carolina, Bonfanti, Paolo, Brancati, Serena, Cacciatore, Francesco, Caiano, Lucia, Cannata, Francesco, Carrozzi, Laura, Cascio, Antonio, Cingolani, Antonella, Cipollone, Francesco, Colomba, Claudia, Crisetti, Annalisa, Crosta, Francesca, Danzi, Gian B., D'Ardes, Damiano, de Gaetano Donati, Katleen, Di Gennaro, Francesco, Di Palma, Gisella, Di Tano, Giuseppe, Fantoni, Massimo, Filippini, Tommaso, Fioretto, Paola, Fusco, Francesco M., Gentile, Ivan, Grisafi, Leonardo, Guarnieri, Gabriella, Landi, Francesco, Larizza, Giovanni, Leone, Armando, Maccagni, Gloria, Maccarella, Sandro, Mapelli, Massimo, Maragna, Riccardo, Marcucci, Rossella, Maresca, Giulio, Marotta, Claudia, Marra, Lorenzo, Mastroianni, Franco, Mengozzi, Alessandro, Menichetti, Francesco, Milic, Jovana, Murri, Rita, Montineri, Arturo, Mussinelli, Roberta, Mussini, Cristina, Musso, Maria, Odone, Anna, Olivieri, Marco, Pasi, Emanuela, Petri, Francesco, Pinchera, Biagio, Pivato, Carlo A., Pizzi, Roberto, Poletti, Venerino, Raffaelli, Francesca, Ravaglia, Claudia, Righetti, Giulia, Rognoni, Andrea, Rossato, Marco, Rossi, Marianna, Sabena, Anna, Salinaro, Francesco, Sangiovanni, Vincenzo, Sanrocco, Carlo, Scarafino, Antonio, Scorzolini, Laura, Sgariglia, Raffaella, Simeone, Paola G., Spinoni, Enrico, Torti, Carlo, Trecarichi, Enrico M., Vezzani, Francesca, Veronesi, Giovanni, Vettor, Roberto, Vianello, Andrea, Vinceti, Marco, De Caterina, Raffaele, Iacoviello, LiciaEnlace del recurso
Publicado 2020
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9285por Singh, Aditi, Salaytah, Natali, Lebovic, Daniel, Sako, Zeyad, Pounders, Zachary, Kohler, Laura, Kafri, Zyad, Saravolatz, Louis, Coyle, Meredith, Patel, Hemang“…Severe disease is associated with acute respiratory distress syndrome (ARDS), use of mechanical ventilation, ICU stay and prolonged hospitalization, The role of the immune system in the pathogenesis of COVID-19 disease is still unclear, which imposes limitations on identifying potential immunotherapy that can improve care for acute and chronic phases of COVID-19 in conjunction with current therapies. …”
Publicado 2021
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9286por Liu, Panpan, Huang, Zhijun, Yin, Mingzhu, Liu, Chun, Chen, Xiang, Pan, Pinhua, Kuang, Yehong“…We focus on the Acute Respiratory Distress Syndrome (ARDS)-like changes and overactivation of Th17 cells (these produce cytokines) in patients with COVID-19. …”
Publicado 2020
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9287por Rao, Shivani, Warrior, Surbhi, Gezer, Sefer, Venugopal, Parameswaran, Jain, Shivi“…In critically ill patients with the disease, common symptoms include sepsis, severe pneumonia with acute respiratory distress syndrome (ARDS), and complications such as coagulopathy and thrombosis. …”
Publicado 2020
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9288por Van Dreden, Patrick, Voiriot, Guillaume, Alabbadi, Alexandre, Elalamy, Ismail, Papageorgiou, Loula, Cost, Hélène, Rousseau, Aurélie, Turpin, Matthieu, Fartoukh, Muriel, Gerotziafas, Grigorios T.“…Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19) characterized by acute pneumonia which may progress to respiratory failure and life-threatening complications, including acute respiratory distress syndrome (ARDS) and multisystem organ failure with fatal outcome. …”
Publicado 2020
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9289por Alhumaid, Saad, Al Mutair, Abbas, Busubaih, Jawad S., Al Dossary, Nourah, Alsuliman, Murtadha, Baltyour, Sarah A., Alissa, Ibrahim, Al Hassar, Hassan I., Al Aithan, Noor A., Albassri, Hani A., AlOmran, Suliman A., ALGhazal, Raed M., Busbaih, Ahmed, Alsalem, Nasser A., Alagnam, Waseem, Alyousef, Mohammed Y., Alseffay, Abdulaziz U., Al Aish, Hussain A., Aldiaram, Ali, Al eissa, Hisham A., Alhumaid, Murtadha A., Bukhamseen, Ali N., Al mutared, Koblan M., Aljwisim, Abdullah H., Twibah, Abdullah M., AlSaeed, Meteab M., Alkhalaf, Hussien A., ALShakhs, Fatemah M., Koritala, Thoyaja, Al-Tawfiq, Jaffar A., Dhama, Kuldeep, Rabaan, Ali A., Al-Omari, Awad“…Key determinants that lead to increased mortality in CRC patients infected with COVID-19 include older age (≥ 60 years old); male gender; Asian and Hispanic ethnicity; if SARS-CoV-2 was acquired from hospital source; advanced CRC (stage III and IV); if patient received chemotherapies or surgical treatment; and if patient was admitted to ICU, ventilated or experienced ARDS.…”
Publicado 2022
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9290“…The major complication is acute respiratory distress syndrome (ARDS) but systemic complications such as cardiomyopathy, acute kidney injury, encephalopathy and coagulopathy are being identified. …”
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9291por Ghati, Nirmal, Roy, Ambuj, Bhatnagar, Sushma, Bhati, Sumit, Bhushan, Sudha, Mahendran, Manjit, Thakur, Abhishek, Tiwari, Pawan, Dwivedi, Tanima, Mani, Kalaivani, Gupta, Ritu, Mohan, Anant, Garg, Rakesh, Saxena, Anita, Guleria, Randeep, Deepti, Siddharthan“…Other clinical outcomes that will be assessed include progression to Acute Respiratory Distress Syndrome (ARDS), shock, ICU admission, length of ICU admission, length of hospital admission, and in-hospital mortality. …”
Publicado 2020
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9292por Yadav, Babita, Rai, Amit, Mundada, Pallavi Suresh, Singhal, Richa, Rao, B. C. S., Rana, Rakesh, Srikanth, Narayanam“…Critically ill patients with ARDS (acute respiratory distress syndrome), requiring invasive respiratory support in the intensive care unit, known case of any malignancy, immune-compromised state (e.g. …”
Publicado 2021
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9293por Abdolahi, Nafiseh, Kaheh, Effat, Golsha, Roghieh, Khodabakhshi, Behnaz, Norouzi, Alireza, Khandashpoor, Mahmoud, Besharat, Sima, Tavassoli, Samane, Livani, Somayeh, Azimi, Sadegh Ali, Gharib, Mohammad Hadi, Peivandi, Babak, Fazel, Abdolreza, Shirzad-Aski, Hesamaddin, Roshandel, Gholamreza“…Most of these patients develop acute respiratory distress syndrome (ARDS) due to excessive inflammatory response and the ensuing cytokine storm. …”
Publicado 2020
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9294“…COVID-19 is primarily a respiratory illness and 10-20% of infected individuals develop severe disease with interstitial pneumonia or acute respiratory distress syndrome (ARDS). In this subgroup of patients, severe clinical manifestations are postulated to result from a hyperactive immune response. …”
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9295por Feld, Jonathan, Demakos, Erin P., Odchimar-Reissig, Rosalie, Tremblay, Douglas, Alli, Saudia, Sewah, Darshanie, Navada, Shyamala C., Silverman, Lewis R.“…Common symptoms were URI symptoms (15) and fever (14). ARDS and pneumonia occurred in 4 pts. The most common treatments were hydroxychloroquine (n=4), steroids (n=3), and azithromycin (n=2). …”
Publicado 2020
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9296por Gavrilina, Olga A., Zakurdaeva, Kristina, Vorobyev, Vladimir I., Vasileva, Anastasia N., Butaev, Lev S., Sukhareva, Alena, Gavrilova, Lubov, Samoylova, Olga, Grishunina, Maria, Ochirova, Ochsana, Karpova, Alina, Panteleeva, Olga, Kunst, Mikhail A., Shuvaev, Vasily, Rakhmani, Anzhelika, Gaponova, Tatiana V., Galstyan, Gennadiy M., Troitskaya, Vera V., Luchkin, Anton V., Parovichnikova, Elena N., Savchenko, Valery“…Fifty (28%) pts experienced COVID-19 complications, the most common were pneumonia in 125 (71%) pts, respiratory failure in 82(47%) pts, ARDS in 11(6%) pts, cytokine release syndrome in 15(9%) pts, multiple organ failure in 10(6%) pts, sepsis in 6(3%) pts, and pulmonary bleeding in 1(0,6%). …”
Publicado 2020
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9297por Caballero Bermejo, Antonio F., Ruiz-Antorán, Belén, Fernández Cruz, Ana, Diago Sempere, Elena, Callejas Díaz, Alejandro, Múñez Rubio, Elena, Avendaño-Solá, Cristina, Ramos Martínez, Antonio, Sancho López, Aránzazu“…There is the hypothesis that the use of anti-IL6 inhibitors at an earlier state during the hyperinflammatory syndrome would be beneficial and may avoid progressing to ARDS. On the other hand, the standard of care has changed and nowadays the use of corticosteroids has become part of the SOC in the treatment of COVID-19 pneumonia. …”
Publicado 2020
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9298por Moraleda, Jose M., Carlo-Stella, Carmelo, Garcia-Bernal, David, Jara Rubio, Ruben, Andreu, Enriqueta, Calabretta, Eleonora, Aghemo, Alessio, Diaz-Ricart, Maribel, Palomo, Marta, Carreras, Enric, Vlodavsky, Israel, Iacobelli, Massimo, Fareed, Jawed, Castro, Pedro, Fernandez, Sara, Mo, Clifton C., Weinhouse, Gerald L., Cooke, Kenneth R., Soiffer, Robert J., Baron, Rebecca M., O'Gorman, Peter, Yanik, Gregory, Pagliuca, Antonio, Richardson, Paul G.“…The third stage COVID-19 is the most severe, characterized by systemic hyperinflammation, acute respiratory distress syndrome (ARDS) and generalized microangiopathy, with significantly elevated biomarkers including IL-2, IL-6, IL-7, granulocyte-colony stimulating factor, macrophage inflammatory protein 1α, tumor necrosis factor-α, C-reactive protein, ferritin, D-dimer, von Willebrand factor (vWF) and thrombomodulin (TM). …”
Publicado 2020
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9299por Chawla, Rajesh, Dixit, Subhal B, Zirpe, Kapil Gangadhar, Chaudhry, Dhruva, Khilnani, G C, Mehta, Yatin, Khatib, Khalid Ismail, Jagiasi, Bharat G, Chanchalani, Gunjan, Mishra, Rajesh C, Samavedam, Srinivas, Govil, Deepak, Gupta, Sachin, Prayag, Shirish, Ramasubban, Suresh, Dobariya, Jayesh, Marwah, Vikas, Sehgal, Inder, Jog, Sameer Arvind, Kulkarni, Atul Prabhakar“…NIV in Viral Pneumonitis ARDS: Recommendations: NIV cannot be considered as a treatment of choice for patients with acute respiratory failure with H1N1 pneumonia. …”
Publicado 2020
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9300“…Key Inclusion criteria • Confirmed diagnosis of SARS-CoV-2 infection (eg, via polymerase chain reaction [PCR] and/or antibody test) presenting as severe COVID-19 requiring hospitalization • Severe pneumonia, acute lung injury, or ARDS confirmed by computed tomography (CT) or X-ray at Screening or within the 3 days prior to Screening, as part of the patient’s routine clinical care • Respiratory distress requiring mechanical ventilation, which can be either invasive (requiring endotracheal intubation) or non-invasive (with continuous positive airway pressure [CPAP] or bilevel positive airway pressure [BiPAP]) Key Exclusion criteria • Patient is not expected to survive for more than 24 hours • Patient is on invasive mechanical ventilation with intubation for more than 48 hours prior to Screening • Severe pre-existing cardiac disease (ie, NYHA Class 3 or Class 4, acute coronary syndrome, or persistent ventricular tachyarrhythmias) • Patient has an unresolved Neisseria meningitidis infection Excluded medications and therapies • Current treatment with a complement inhibitor • Intravenous immunoglobulin (IVIg) within 4 weeks prior to randomization on Day 1 Excluded prior/concurrent clinical study experience • Treatment with investigational therapy in a clinical study within 30 days before randomization, or within 5 half-lives of that investigational therapy, whichever is greater • Exceptions a. …”
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