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1por Kattner, Aila AkosuaEnlace del recurso
Publicado 2023
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2“…The ATTAC workflow brings together guidelines supporting both the data prime movers and re-users. …”
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3por Wang, Zhao V., Mu, James, Schraw, Todd D., Gautron, Laurent, Elmquist, Joel K., Zhang, Bei B., Brownlee, Michael, Scherer, Philipp E.“…Here, we present a mouse model for inducible and reversible ablation of pancreatic β-cells named the PANIC-ATTAC (pancreatic islet β-cell apoptosis through targeted activation of caspase 8) mouse. …”
Publicado 2008
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4por Yuan, Hongyan, Wang, Xiaoyi, Lu, Jin, Zhang, Qiongsi, Brandina, Irina, Alexandrov, Ilya, Glazer, Robert I.“…To address this question, a novel transgenic animal model was developed by crossing MMTV-NeuT mice containing a constitutively active ErbB2 gene into the FAT-ATTAC (fat apoptosis through targeted activation of caspase 8) background, which expresses an inducible caspase 8 fusion protein targeted to mammary adipose tissue. …”
Publicado 2018
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7por Duits, Danique E. M., Salvagno, Camilla, Raeven, Elisabeth A. M., Vrijland, Kim, Stip, Marjolein C., Hau, Cheei-Sing, Kaldenbach, Daphne, de Visser, Karin E.“…In order to achieve specific neutrophil depletion, we cloned the ATTAC construct under the human migration inhibitory factor-related protein 8 (hMRP8) promotor. …”
Publicado 2022
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8por Fueyo-Marcos, Elena, Lopez-Pernas, Gema, Fustero-Torre, Coral, Antón, Marta Elena, Al-Shahrour, Fátima, Fernández-Capetillo, Oscar, Murga, Matilde“…To address this question, we developed an inducible suicidal knock-in mouse allele of Pd-l1 (PD-L1(ATTAC)) which allows for the tracking and specific elimination of PD-L1-expressing cells in adult tissues. …”
Publicado 2023
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9por Yuan, Hongyan, Jin, Lu, Xiang, Handan, Bhattacharya, Anannya, Brandish, Philip E., Baltus, Gretchen, Tong, Alexander, Zhou, Changyan, Glazer, Robert I.“…Tumor progression in NeuT/ATTAC mice was unaffected by weekly injection of anti-PD-1 over four months. …”
Publicado 2022
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13por Lu, Kuan-Jung, Sheu, Joen-Rong, Teng, Ruei-Dun, Jayakumar, Tanasekar, Chung, Chi-Li, Hsieh, Cheng-Ying“…We constructed a novel lenti-INK-ATTAC viral vector to introduce INK-ATTAC genes to the ipsilateral brain and locally eliminate senescent brain cells by administering AP20187 to activate caspase-8 apoptotic cascade. …”
Publicado 2023
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14por Khan, Irfan, Schmidt, Marcel O., Kallakury, Bhaskar, Jain, Sidharth, Mehdikhani, Shaunt, Levi, Moshe, Mendonca, Margarida, Welch, William, Riegel, Anna T., Wilcox, Christopher S., Wellstein, Anton“…Angiotensin II treatment for 3 weeks induced ATTAC transgene expression in kidneys but not in lung, spleen and brain tissues. …”
Publicado 2021
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15por Chandra, Abhishek, Lagnado, Anthony B., Farr, Joshua N., Doolittle, Madison, Tchkonia, Tamara, Kirkland, James L., LeBrasseur, Nathan K., Robbins, Paul D., Niedernhofer, Laura J., Ikeno, Yuji, Passos, João F., Monroe, David G., Pignolo, Robert J., Khosla, Sundeep“…Next, we used the p21‐ATTAC mouse and the established p16‐INK‐ATTAC mouse to directly compare the contributions of p21(Cip1) versus p16(Ink4a) in driving cellular senescence in a condition where a tissue phenotype (bone loss and increased marrow adiposity) is clearly driven by cellular senescence—specifically, radiation‐induced osteoporosis. …”
Publicado 2022
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17por Xu, Ming, Palmer, Allyson K, Ding, Husheng, Weivoda, Megan M, Pirtskhalava, Tamar, White, Thomas A, Sepe, Anna, Johnson, Kurt O, Stout, Michael B, Giorgadze, Nino, Jensen, Michael D, LeBrasseur, Nathan K, Tchkonia, Tamar, Kirkland, James L“…We previously found genetic clearance of senescent cells from progeroid INK-ATTAC mice prevents lipodystrophy. Here we show that primary human senescent fat progenitors secrete activin A and directly inhibit adipogenesis in non-senescent progenitors. …”
Publicado 2015
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18por Sheng, Gao, Yuan, Hongyan, Jin, Lu, Ranjit, Suman, Panov, Julia, Lu, Xun, Levi, Moshe, Glazer, Robert I.“…Induction of fibrosis in NeuT/ATTAC mice led to more rapid tumor development and an inflammatory and fibrotic stromal environment. …”
Publicado 2021
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19por Farr, Joshua N., Xu, Ming, Weivoda, Megan M., Monroe, David G., Fraser, Daniel G., Onken, Jennifer L., Negley, Brittany A., Sfeir, Jad G., Ogrodnik, Mikolaj B., Hachfeld, Christine M., LeBrasseur, Nathan K., Drake, Matthew T., Pignolo, Robert J., Pirtskhalava, Tamar, Tchkonia, Tamara, Oursler, Merry Jo, Kirkland, James L., Khosla, Sundeep“…In particular, we used either genetic (i.e., the INK-ATTAC “suicide” transgene encoding an inducible caspase 8 expressed specifically in senescent cells(2–4)) or pharmacological (i.e., “senolytic” compounds(5,6)) means to eliminate senescent cells. …”
Publicado 2017
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20por Baranwal, Gaurav, Creed, Heidi A., Black, Laurence M., Auger, Alexa, Quach, Alexander M., Vegiraju, Rahul, Eckenrode, Han E., Agarwal, Anupam, Rutkowski, Joseph M.“…Reduced collagen deposition and improved functional recovery over time was also identified in KidVD mice. In KidVD‐POD‐ATTAC mice, an increased number of podocytes were counted at 28 days post‐injury. …”
Publicado 2021
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