Mostrando 1 - 20 Resultados de 49 Para Buscar '"Ace of Base"', tiempo de consulta: 2.08s Limitar resultados
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    ACE2 and ACE: structure-based insights into mechanism, regulation and receptor recognition by SARS-CoV
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    “…Here, we developed an ACE2-based biosensor designed to detect both SARS-CoV-2 S1 mutations and neutralizing antibodies. …”
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    Versatile role of ACE2-based biosensors for detection of SARS-CoV-2 variants and neutralizing antibodies
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    An ACE2-Based Decoy Inhibitor Effectively Neutralizes SARS-CoV-2 Omicron BA.5 Variant
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    Specific Activation of T Cells by an ACE2-Based CAR-Like Receptor upon Recognition of SARS-CoV-2 Spike Protein
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    “…Finally, we demonstrate that ACE2-based therapeutics confer a broad-spectrum neutralization potency for ACE2-tropic viruses, including SARS-CoV-2 variants of concern in contrast to therapeutic MAb.…”
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    Characterization of a Novel ACE2-Based Therapeutic with Enhanced Rather than Reduced Activity against SARS-CoV-2 Variants
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    por Zhu, Qian, Zhou, Xiaohong
    Publicado 2022
    “…We constructed a human ACE2 (hACE2)-based peptide pair by ligating discontinuous key residues involved in the hACE2–S(_RBD) interaction. …”
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    A colorimetric sandwich-type bioassay for SARS-CoV-2 using a hACE2-based affinity peptide pair
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    Design of hACE2-based small peptide inhibitors against spike protein of SARS-CoV-2: a computational approach
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    ACE2-based capacitance sensor for rapid native SARS-CoV-2 detection in biological fluids and its correlation with real-time PCR
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    por Feng, Qiushi, Li, Lin, Wang, Xiaosheng
    Publicado 2020
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    Identifying Pathways and Networks Associated With the SARS-CoV-2 Cell Receptor ACE2 Based on Gene Expression Profiles in Normal and SARS-CoV-2-Infected Human Tissues
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    The Treatment Effect of an ACE-Inhibitor Based Regimen with Perindopril in Relation to Beta-Blocker use in 29,463 Patients with Vascular Disease: a Combined Analysis of Individual Data of ADVANCE, EUROPA and PROGRESS Trials
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    “…Recent developments in ACE2-based SARS-CoV-2 detection modalities accentuate the potential of this natural host-virus interaction for developing point-of-care (POC) COVID-19 diagnostic systems. …”
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    Angiotensin-Converting Enzyme 2-Based Biosensing Modalities and Devices for Coronavirus Detection
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    “…Recently, in situ evidence has been presented that SARS-CoV-2 can infect cells in engineered human vascular endothelium, which can be effectively blocked by using clinical-grade recombinant human ACE2. Based on the circumstantial evidence present in the literature, we propose a SARS-CoV-2 cell entry receptor ACE2 based mechanism for vascular thrombosis in COVID-19 patients.…”
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    SARS-CoV-2 cell entry receptor ACE2 mediated endothelial dysfunction leads to vascular thrombosis in COVID-19 patients
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    por Li, Shuo, Liu, Xue, Liu, Gang, Liu, Chao
    Publicado 2023
    “…Nanotechnology has developed excellent solutions to combat the virus pandemic, such as ACE2-based nanodecoys, nanobodies, nanovaccines, and drug nanocarriers. …”
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    Biomimetic Nanotechnology for SARS-CoV-2 Treatment
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    “…These results reveal the feasibility of our pharmacological approach using a novel FLAP antagonist encapsulated into Ace-DEX-based NPs with improved efficiency in blood to suppress leukotriene biosynthesis. …”
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    Ethoxy acetalated dextran-based nanocarriers accomplish efficient inhibition of leukotriene formation by a novel FLAP antagonist in human leukocytes and blood
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    “…ACE2’s tissue distribution, affected by comorbidities and sex, explains the broad tropism of coronaviruses and the clinical manifestations of SARS and COVID-19. ACE2-based therapeutics provide a universal strategy to prevent and treat SARS-CoV-2 infections, applicable to all SARS-CoV-2 variants and other emerging zoonotic coronaviruses exploiting ACE2 as their cellular receptor.…”
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    Angiotensin Converting Enzyme 2 - at the Heart of the COVID-19 pandemic
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    por Ni, He, Li, Lin, Liu, Guang, Hu, Song-Qing
    Publicado 2012
    “…ACE-inhibitory peptides can lower blood pressure by inhibiting ACE activity. Based on the sequence of an ACE-inhibitory hexapeptide (TPTQQS) purified from yeast, enzyme kinetics experiments, isothermal titration calorimetry (ITC), and a docking simulation were performed. …”
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    Inhibition Mechanism and Model of an Angiotensin I-Converting Enzyme (ACE)-Inhibitory Hexapeptide from Yeast (Saccharomyces cerevisiae)
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    “…Here, we evaluate an ACE2-based immunoadhesin that we have developed early in the pandemic against some of the recent variants of concern (VoCs), including the Delta and the Omicron variants. …”
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    Anti-SARS-CoV-2 immunoadhesin remains effective against Omicron and other emerging variants of concern
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    “…As a proof of concept, we achieve an excellent performance for acetaminophen (Ace) detection based on the specificity of Arg and Ace, with excellent linearity, low detection limits, and good recoveries. …”
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    Electrogenerated chemiluminescence of a Ru(bpy)(3)(2+)/arginine system: a specific and sensitive detection of acetaminophen
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    “…Herein, we suggest 4 potential drug candidates (an ACE2-based peptide, remdesivir, 3CLpro-1 and a novel vinylsulfone protease inhibitor) that can be used to treat patients suffering with the 2019-nCoV. …”
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    Learning from the Past: Possible Urgent Prevention and Treatment Options for Severe Acute Respiratory Infections Caused by 2019-nCoV
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    “…In summary, we provide evidence that RNA transcript therapy (RTT) is a promising approach for ACE2-based treatment of liver and lung fibrosis to be tested in fibrotic disease models.…”
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    Translation of Angiotensin-Converting Enzyme 2 upon Liver- and Lung-Targeted Delivery of Optimized Chemically Modified mRNA
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