Mostrando 41 - 60 Resultados de 326 Para Buscar '"Acra"', tiempo de consulta: 0.09s Limitar resultados
  1. 41
    “…Data confirmed the involvement of AcrA/B and OqxAB efflux pump as a carbapenem resistance mechanism in selected bacteria. …”
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    Multicentre study of the main carbapenem resistance mechanisms in important members of the Enterobacteriaceae family in Iran
  2. 42
    por Kawabe, Yoshinori, Schaap, Pauline
    Publicado 2023
    “…To understand how cAMP's role in aggregation evolved, we deleted the acaA, carA and pdsA genes of Polysphondylium violaceum, a sister species to group 4. acaAˉ fruiting bodies had thinner stalks but otherwise developed normally. Deletion of acrA, which was similarly expressed as acaA, reduced aggregation centre initiation and, as also occurred after D. discoideum acrA deletion, caused spore instability. …”
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    Development of the dictyostelid Polysphondylium violaceum does not require secreted cAMP
  3. 43
    “…In the largest evaluation of biocide resistance genes in Klebsiella spp. to our knowledge, the presence of qacA, qacE, qac∆E, and acrA was less common than has been reported elsewhere. …”
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    543. Biocide Resistance Genes in Klebsiella spp. Infections from Trauma Patients in Iraq and Afghanistan
  4. 44
    “…We define the structural dynamics of AcrA and find that an inhibitor can inflict long-range stabilisation across all four of its domains, whereas an interacting efflux substrate has minimal effect. …”
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    Conformational restriction shapes the inhibition of a multidrug efflux adaptor protein
  5. 45
    “…Deletion of csrA or mutagenesis of the CsrA binding sites reduced production of both AcrA and AcrB. Nucleotide substitutions at the 5′ UTR of acrA mRNA that could potentially weaken the inhibitory RNA secondary structure, allow for more efficient translation of the AcrAB proteins. …”
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    CsrA maximizes expression of the AcrAB multidrug resistance transporter
  6. 46
    “…Infections with single deletion mutant strains indicate that both AcrA and AcrB favor the viability of the intracellular bacteria. …”
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    Role of the MDR Efflux Pump AcrAB in Epithelial Cell Invasion by Shigella flexneri
  7. 47
    “…We deleted PKA and the adenylate cyclases AcrA and AcgA, which synthesize cAMP for PKA activation, in the intermediate species Polysphondylium, which can develop into either cysts or into multicellular structures. …”
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    A Conserved Signalling Pathway for Amoebozoan Encystation that was Co-Opted for Multicellular Development
  8. 48
    “…We examined five groups of AcrB and AcrA mutants, defective in different aspects of assembly and substrate efflux. …”
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    Insight into the AcrAB-TolC Complex Assembly Process Learned from Competition Studies
  9. 49
    “…Transcription activator RamA is linked to multidrug resistance of Klebsiella pneumoniae through controlling genes that encode efflux pumps (acrA) and porin‐regulating antisense RNA (micF). …”
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    Structures of Class I and Class II Transcription Complexes Reveal the Molecular Basis of RamA‐Dependent Transcription Activation
  10. 50
    “…However, genotypically, 7 (14.6%) of the isolates harboured acrA, acrB and tolC, 8 (16.7%) harboured acrA, acrD and tolC while 33 (68.8%) possessed acrA, acrB, acrD and tolC. …”
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    Molecular and phenotypic characterization of efflux pump and biofilm in multi-drug resistant non-typhoidal Salmonella Serovars isolated from food animals and handlers in Lagos Nigeria
  11. 51
    “…Correspondingly, deleting cydD led to a decreased accumulation of TMP within bacterial cells, and further deleting acrA, acrB, or tolC restored TMP sensitivity to ΔcydD. …”
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    Reducing the Periplasmic Glutathione Content Makes Escherichia coli Resistant to Trimethoprim and Other Antimicrobial Drugs
  12. 52
    “…Killed cells release a resistance-enhancing factor that we identify as AcrA, a periplasmic component of RND efflux pumps. …”
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    Dead cells release a ‘necrosignal’ that activates antibiotic survival pathways in bacterial swarms
  13. 53
    “…We were able to produce and purify the OPS II-AcrA glycoconjugate, and MS analysis confirmed correct glycan was produced and attached. …”
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    Production of a recombinant vaccine candidate against Burkholderia pseudomallei exploiting the bacterial N-glycosylation machinery
  14. 54
    “…RESULTS: In this work we expressed the C. jejuni oligosaccharyltansferase (OTase) PglB, responsible for N-linked protein glycosylation together with a suitable acceptor protein (AcrA) in Yersinia enterocolitica O9 cells. MS analysis of the acceptor protein demonstrated the transfer of a polymer of N-formylperosamine to AcrA in vivo. …”
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    Exploiting the Campylobacter jejuni protein glycosylation system for glycoengineering vaccines and diagnostic tools directed against brucellosis
  15. 55
    “…We found that the deletion of genes encoding AcrA and/or AcrB leads to decreased survival of LF82 within macrophages. …”
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    AcrAB efflux pump impacts on the survival of adherent-invasive Escherichia coli strain LF82 inside macrophages
  16. 56
    por Debroy, Reetika, Ramaiah, Sudha
    Publicado 2023
    “…The AMR genes were subjected to clustering, topological and functional enrichment analysis, revealing rpsE (RpsE), acrA (AcrA) and arnT (ArnT) as novel therapeutic drug targets for hindering drug resistance in the pathogenic strain. …”
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    Translational protein RpsE as an alternative target for novel nucleoside analogues to treat MDR Enterobacter cloacae ATCC 13047: network analysis and molecular dynamics study
  17. 57
    “…In strains with high fluoroquinolone resistance, acrA overexpression was observed in addition to QRDR mutation. …”
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    The Drug-Specific Propensity Regarding the Acquisition of Fluoroquinolone Resistance in Escherichia coli: An in vitro Challenge and DNA Mutation Analysis
  18. 58
    “…Expression of efflux genes acrA, acrB, acrR and tolC was measured using real-time PCR. …”
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    Enhanced resistance to fluoroquinolones in laboratory-grown mutants & clinical isolates of Shigella due to synergism between efflux pump expression & mutations in quinolone resistance determining region
  19. 59
    “…The expression levels of the genes acrA, oqxA, ramA, rarA, and rpoB were determined by reverse-transcription quantitative PCR. …”
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    Development of Tigecycline Resistance in Carbapenemase-Producing Klebsiella pneumoniae Sequence Type 147 via AcrAB Overproduction Mediated by Replacement of the ramA Promoter
  20. 60
    “…In this study, a strong correlation between ertapenem resistance and AcrA overexpression was observed which has not been reported previously. …”
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    AcrAB-TolC efflux pump system plays a role in carbapenem non-susceptibility in Escherichia coli
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