Mostrando 1 - 20 Resultados de 171 Para Buscar '"Adam-12"', tiempo de consulta: 1.77s Limitar resultados
  1. 1
    “…We designed a specific inhibitor of ADAM12 based on its recombinant prodomain (PA12), which selectively inhibits ADAM12 but not ADAM10 or ADAM17. …”
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    Targeting autocrine HB-EGF signaling with specific ADAM12 inhibition using recombinant ADAM12 prodomain
  2. 2
    “…ADAM 12 (meltrin alpha) belongs to a large family of molecules, consisting of members with both disintegrin and metalloproteinase properties. …”
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    ADAM 12: A Putative Marker of Oligodendrogliomas?
  3. 3
    “…Moreover, CRISPR/Cas9-mediated knockout of ADAM12 in human HeLa carcinoma cells results in reduced shedding of the basigin reporter, which can be rescued by ADAM12 re-expression. …”
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    Identification of ADAM12 as a Novel Basigin Sheddase
  4. 4
    “…We showed microRNA‐29a (miR‐29a) modulates ADAM12 expression in the setting of diabetes and ischemia. …”
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    microRNA‐29a Regulates ADAM12 Through Direct Interaction With ADAM12 mRNA and Modulates Postischemic Perfusion Recovery
  5. 5
    “…Previous studies that evaluated the association between a disintegrin and metalloprotease 12 (ADAM12) gene polymorphisms and knee osteoarthritis (KOA) have given controversial and indefinite results. …”
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    Association of ADAM12 gene polymorphisms with knee osteoarthritis susceptibility
  6. 6
    “…Pathway analyses of ADAM12 in HCC revealed ADAM12-correlated signalling pathways, and the expression level of ADAM12 was associated with immune cell infiltration. …”
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    ADAM12 is an independent predictor of poor prognosis in liver cancer
  7. 7
    “…The present study aims to better understand how ADAM12 impacts on TGF-β receptors trafficking and TGF-β signaling. …”
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    In silico investigation of ADAM12 effect on TGF-β receptors trafficking
  8. 8
    por Wu, Zhen, Xu, Xin-Wei, Zhang, Xiao-Wen
    Publicado 2017
    “…BACKGROUND: The pathology of osteoarthritis (OA) is partly attributed to genetic factors; however, the role of ADAM12 polymorphism is still controversial. It is necessary to perform a meta-analysis to investigate this possible correlation. …”
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    The association of ADAM12 polymorphism with osteoarthritis susceptibility: a meta-analysis
  9. 9
    “…The clinical outcome correlated with the ephrin-A1 and ADAM12 serum levels during the first week of hospitalization. …”
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    Ephrin-A1 and the sheddase ADAM12 are upregulated in COVID-19
  10. 10
    “…ADAM12 is induced in vitro upon differentiation of naïve T cells to Th17 cells or IL-17-secreting Tregs. …”
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    The Metalloprotease ADAM12 Regulates the Effector Function of Human Th17 Cells
  11. 11
    “…Six different somatic missense mutations in the human ADAM12 gene have been identified so far in breast cancer. …”
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    Phenotypic Diversity of Breast Cancer-Related Mutations in Metalloproteinase-Disintegrin ADAM12
  12. 12
    “…ADAM metallopeptidase domain 12 (ADAM12) has been demonstrated to mediate cell proliferation and apoptosis resistance in several types of cancer cells. …”
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    ADAM12 silencing promotes cellular apoptosis by activating autophagy in choriocarcinoma cells
  13. 13
    “…There have been many studies on the correlation between ADAM12 polymorphisms and genetic susceptibility to osteoarthritis, but the results remain inconclusive. …”
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    The association between ADAM12 gene polymorphisms and osteoarthritis: an updated meta-analysis
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    Correction: The association between ADAM12 gene polymorphisms and osteoarthritis: an updated meta-analysis
  15. 15
    “…In this paper, we show that, in cancer cells, hypoxia increased the levels and activity of the ADAM12 metalloprotease in a Notch signaling–dependent manner, leading to increased ectodomain shedding of the epidermal growth factor (EGF) receptor (EGFR) ligand heparin-binding EGF-like growth factor. …”
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    Notch increases the shedding of HB-EGF by ADAM12 to potentiate invadopodia formation in hypoxia
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    Synonymous SNP influences Adam12 mRNA expression level in synovial tissue
  17. 17
    “…Importantly, the proteolytic processing and intracellular trafficking of the corresponding ADAM12-La and ADAM12-Lb proteins are different. While ADAM12-La is cleaved and trafficked to the cell surface in a manner similar to ADAM12 in other species, ADAM12-Lb is retained in the ER and is not proteolytically processed. …”
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    Alternative mRNA Splicing Generates Two Distinct ADAM12 Prodomain Variants
  18. 18
    “…The increased expression of the Disintegrin and Metalloprotease ADAM12 has been associated with human cancers, however its role remain unclear. …”
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    The Disintegrin and Metalloprotease ADAM12 Is Associated with TGF-β-Induced Epithelial to Mesenchymal Transition
  19. 19
    “…Importantly, TSPAN8 enhanced HCC invasion and metastasis by increasing ADAM12m expression. We therefore conclude that TSPAN8 and ADAM12m may be useful therapeutic targets for the prevention of HCC progression and metastasis.…”
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    Tetraspanin-8 promotes hepatocellular carcinoma metastasis by increasing ADAM12m expression
  20. 20
    “…In this study, we observed that 5-FU induces expression of the ADAM12 isoform ADAM12-L but not ADAM12-S in BC cells and in recurrent BC tissues. …”
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    ADAM12-L confers acquired 5-fluorouracil resistance in breast cancer cells
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