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  1. 2001
    “…AVAILABILITY AND IMPLEMENTATION: PSPred-ALE is available at https://github.com/jiaoshihu/PSPred-ALE and Zenodo (https://doi.org/10.5281/zenodo.8330277).…”
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    Adaptive learning embedding features to improve the predictive performance of SARS-CoV-2 phosphorylation sites
  2. 2002
    “…Although similar increased activation brain areas were identified in ALE with or without ROI studies, analysis including ROI studies had a higher ALE value. …”
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    Correlation Between Brain Activation Changes and Cognitive Improvement Following Cognitive Remediation Therapy in Schizophrenia: An Activation Likelihood Estimation Meta-analysis
  3. 2003
    por Jia, Haomiao, Lubetkin, Erica I.
    Publicado 2020
    “…This study estimated total life expectancy, active life expectancy (ALE), and disability-free life expectancy (DFLE) by disability status among HOS participants. …”
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    Life expectancy and active life expectancy by disability status in older U.S. adults
  4. 2004
    “…Coordinates of activity were extracted from eligible studies to perform an activation likelihood estimation (ALE) using a threshold of uncorrected p <0.001. …”
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    A systematic review and activation likelihood estimation meta-analysis of the central innervation of the lower urinary tract: Pelvic floor motor control and micturition
  5. 2005
    por Bromig, Lukas, Weuster-Botz, Dirk
    Publicado 2023
    “…Adaptive laboratory evolution (ALE) is a valuable complementary tool for modern strain development. …”
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    Accelerated Adaptive Laboratory Evolution by Automated Repeated Batch Processes in Parallelized Bioreactors
  6. 2006
    “…A total of 64 spontaneously hypertensive rats (SHRs) treated with losartan were randomly divided according to the estrogen-deficiency induction by ovariectomy (OVX) or not (SHAM), and whether the implant surface was coated with sodium alendronate (ALE) or not, resulting in four groups: SHR SHAM, SHR SHAM ALE, SHR OVX, and SHR OVX ALE. …”
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    Estrogen Deficiency Impairs Osseointegration in Hypertensive Rats Even Treated with Alendronate Coated on the Implant Surface
  7. 2007
    “…We applied a general activation likelihood estimation (ALE) meta-analysis to 45 fMRI studies. Three individual ALE analyses were performed to assess creativity in different cognitive domains (Musical, Verbal, and Visuo-spatial). …”
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    Where do bright ideas occur in our brain? Meta-analytic evidence from neuroimaging studies of domain-specific creativity
  8. 2008
    “…It was noted that EtOH extract of ALE contained the highest phenolic, flavonoid, and tannin contents and the strongest antioxidants activities including DDPH (94.23%), ABTS (538.75 mmol), FRAP assay (542.62 umol), and β-carotene bleaching (70.74%) compared to the other extracts of ALE. …”
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    Chemicals Compositions, Antioxidant and Anti-Inflammatory Activity of Cynara scolymus Leaves Extracts, and Analysis of Major Bioactive Polyphenols by HPLC
  9. 2009
    “…This work presents the design of an Acoustic Low Energy (ALE) beacon based on the emission of inaudible Linear Frequency Modulated (LFM) signals. …”
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    Noise-Resilient Acoustic Low Energy Beacon for Proximity-Based Indoor Positioning Systems
  10. 2010
    “…Extraction of the stems (ASE) and leaves (ALE) was performed by employing ethanol 70% for 3 × 24 h at 26°C. …”
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    The Cytotoxicity and Nephroprotective Activity of the Ethanol Extracts of Angelica keiskei Koidzumi Stems and Leaves against the NAPQI-Induced Human Embryonic Kidney (HEK293) Cell Line
  11. 2011
    “…RESULTS: Adaptive laboratory evolution (ALE) is an effective method for the development of beneficial phenotypes in industrial microorganisms. …”
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    Development of a cooperative two-factor adaptive-evolution method to enhance lipid production and prevent lipid peroxidation in Schizochytrium sp.
  12. 2012
    “…The main outcome measures were annual MP and axial length elongation (ALE) in treatment and control eyes and their percentage difference between two eyes (drug efficacy). …”
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    Efficacy of 0.01% low dose atropine and its correlation with various factors in myopia control in the Indian population
  13. 2013
    “…It is shown that the beam formulation for ALE and 3D solid elements for the CFD method are the preferred options.…”
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    Modelling and Simulation Strategies for Fluid–Structure-Interactions of Highly Viscous Thermoplastic Melt and Single Fibres—A Numerical Study
  14. 2014
    “…We also isolated strains Δ33b and Δ37c, whose growth was partially restored by adaptive laboratory evolution (ALE). Genome sequencing of nine strains, including those selected following ALE, identified the presence of several Single Nucleotide Variants (SNVs), insertions, deletions, and inversions. …”
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    Mutations identified in engineered Escherichia coli with a reduced genome
  15. 2015
    “…Adaptive laboratory evolution (ALE) has emerged as a valuable method by which to investigate microbial adaptation to a desired environment. …”
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    Evolution of Escherichia coli to 42 °C and Subsequent Genetic Engineering Reveals Adaptive Mechanisms and Novel Mutations
  16. 2016
    “…However, XLGB combined with ALE would not markedly increase the rate of ADR in contrast with ALE alone (p = 0.499). …”
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    The Efficacy and Safety of Chinese Herbal Medicine Xianling Gubao Capsule Combined With Alendronate in the Treatment of Primary Osteoporosis: A Systematic Review and Meta-Analysis of 20 Randomized Controlled Trials
  17. 2017
    “…BC supplementation may induce positive effects on bone metabolism by stimulating bone formation, but appear not to be as effective as ALE.…”
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    Pharmacological and Non-Pharmacological Agents versus Bovine Colostrum Supplementation for the Management of Bone Health Using an Osteoporosis-Induced Rat Model
  18. 2018
    “…Therefore, we implemented comparative MD to evaluate thermostability of PYK of recently developed high temperature resistant strain of E. faecium using Adaptive Laboratory Evolution (ALE) method. After 20ns of simulation at different temperatures, we observed that ALE enhanced strain demonstrated slightly better stability at 300, 340 and 350 K compared to that of the wild type (WT) strain. …”
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    Molecular dynamics simulation of pyruvate kinase to investigate improved thermostability of artificially selected strain in Enterococcus faecium
  19. 2019
    “…In this study, different concentrations of TiO(2) were used to domesticate P. rhodozyma, and at a concentration of 1000 mg/L of TiO(2) for 105 days, the optimal strain JMU-ALE105 for astaxanthin production was obtained. …”
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    Transcriptomics analysis and fed-batch regulation of high astaxanthin-producing Phaffia rhodozyma/Xanthophyllomyces dendrorhous obtained through adaptive laboratory evolution
  20. 2020
    “…Using this strain, a two-step adaptive laboratory evolution (ALE) method was applied to obtain a heat-resistant strain, BIOPOP-3 ALE. …”
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    Complete Genomic Analysis of Enterococcus faecium Heat-Resistant Strain Developed by Two-Step Adaptation Laboratory Evolution Method
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