“…Here, we show that, after initiation of RNA synthesis, non-specific interaction of σ(70) region 1.2, present in all σ(70) family factors, with the non-template strand around position −4 relative to the transcription start site facilitates unwinding of the DNA duplex downstream of the transcription start site. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In total, 40.5% of all IMGs in family medicine held U.S. citizenship at entry to medical school. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Exome sequencing of all three affected family members identified a shared germline heterozygous c.299G>A (p.Arg100Gln) missense variant in IDH1. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Conclusion Perceived social support among individuals experiencing issues with fertility was higher in females than in males across all subscales (SO, family, friends) with the biggest difference seen in SO score. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Recent work has identified several new GCPR families and suggested the possibility of a common evolutionary origin for all of them. Family B (the secretin-receptor family or 'family 2') of the GPCRs is a small but structurally and functionally diverse group of proteins that includes receptors for polypeptide hormones, molecules thought to mediate intercellular interactions at the plasma membrane and a group of Drosophila proteins that regulate stress responses and longevity. …”
Enlace del recurso
Enlace del recurso

“…The new genus is similar to Megalothorax Willem, 1900 and Neelus Folsom, 1896, but it clearly differs from all genera within family Neelidae by a peculiar combination of characters and the presence of some new features, e.g. globular sensillum on Ant. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…To determine the diagnosis and pathogenic mutations of this pedigree, whole exome sequencing, Sanger sequencing and real-time quantitative PCR were performed to detect all the four family members. Our results showed that a new form of compound heterozygous mutation in the PRKN gene, consisting of heterozygous point mutation c.850G > C (p.G284R) along with exon 4 deletion, is the causative genetic factor for EOPD in this pedigree. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Although the functions of all this protein family are still unknown, several disorders in their structure, activity, or expression have been described by researchers. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…OCD group showed a significant positive correlation between dysfunction and all areas of family burden except physical and mental health. …”
Enlace del recurso
Enlace del recurso

“…The results showed that all dimensions of family functions and dyadic adjustment were positively correlated with quality of life in women. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Analyses of thymocytes expressing all V(β) family members show that the interfacial hydrophobicity of amino acids at positions 6 and 7 of the CDR3β segment robustly promotes the development of self-reactive TCRs. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…These processes all involve Rho family small guanosine triphosphatases (GTPases), which are regulated by the opposing actions of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Molecular genetic analysis revealed a heterozygous duplication of exon 2 within the septin 9 (SEPT9) gene in all the affected family members. Such a young child with HNA (aged 2 years) caused by SEPT9 duplication has not been described so far.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The first isoform demonstrated to play an important role in cardiac development was p38α; however, all p38 family members are now known to collaborate in different aspects of cardiomyocyte differentiation and growth. p38 family members have been proposed to have protective and deleterious actions in the stressed myocardium, with the outcome of their action in part dependent on the model system under study and the identity of the activated p38 family member. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…There was no significant associations between all the MMP family members expression levels and DFS. Increased mRNA levels of MMP1, MMP8 and MMP25 were significantly associated with OS. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Relative mRNA expression of all four HER family members was assessed by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This is explained by our observation that all three PIM family kinases can phosphorylate LKB1 at Ser334. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…These processes are critical for normal ovarian function, and all three PPAR family members – alpha, delta, and gamma, are expressed in the ovary. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Although all three Vav family members are expressed in T lymphocytes, the role that Vav3 plays in T cell activation is poorly defined. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Both hspA- and glmM-based phylogenetic trees showed East Asian and African branches. All samples from family members showed natural mixed infection. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso