Mostrando 201 - 220 Resultados de 48,729 Para Buscar '"Alzheimer"', tiempo de consulta: 0.49s Limitar resultados
  1. 201
    “…Profound noradrenergic degeneration in Alzheimer's disease (AD) patients has been observed for decades, with recent research suggesting that the locus coeruleus (where noradrenergic neurons are mainly located) is a predominant site where AD-related pathology begins. …”
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  2. 202
    por Cornutiu, Gavril
    Publicado 2015
    “…Alzheimer’s disease (AD) has increased from a few cases in a country at the beginning of the 20th century to an incidence of recording a case every 7 seconds in the world. …”
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  3. 203
    “…The Golgi structure is disrupted in a variety of neurodegenerative diseases, suggesting a common mechanism and contribution of Golgi defects in neurodegenerative disorders. A recent study on Alzheimer's disease (AD) revealed that phosphorylation of the Golgi stacking protein GRASP65 disrupts its function in Golgi structure formation, resulting in Golgi fragmentation. …”
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  4. 204
    por Guerreiro, Rita, Bras, Jose
    Publicado 2015
    “…Alzheimer’s disease is the most common type of dementia, and it is characterized by a decline in memory or other thinking skills. …”
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  5. 205
    “…Alzheimer’s disease (AD) is the major cause of dementia in Western societies. …”
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  6. 206
    “…Transcriptome analysis of neurodegenerative diseases using ribonucleic acid sequencing (RNA Seq) and real time quantitative polymerase chain reaction (RT-qPCR) provides for a platform to allow investigators to determine the contribution of various genes to the disease phenotype. In Alzheimer’s disease (AD) there are several candidate genes reported that may be associated with the underlying pathology and are, in addition, alternatively spliced. …”
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  10. 210
    por Wasser, Catherine R, Herz, Joachim
    Publicado 2016
    “…The earliest clinical manifestation of Alzheimer's disease (AD) is cognitive impairment caused by synaptic dysfunction. …”
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  11. 211
    “…Alzheimer’s disease (AD) is a common neurodegenerative disorder with the earliest clinical symptom of olfactory dysfunction, which is a potential clinical marker for AD severity and progression. …”
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  12. 212
    por Hadavi, Darya, Poot, André A.
    Publicado 2016
    “…Alzheimer’s disease (AD) as a progressive and fatal neurodegenerative disease represents a huge unmet need for treatment. …”
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  14. 214
    “…Substantial studies suggest that berberine may be beneficial to Alzheimer’s disease (AD) by limiting the pathogenesis of extracellular amyloid plaques and intracellular neurofibrillary tangles. …”
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  15. 215
    “…OBJECTIVE: To test whether plasma tau is altered in Alzheimer disease (AD) and whether it is related to changes in cognition, CSF biomarkers of AD pathology (including β-amyloid [Aβ] and tau), brain atrophy, and brain metabolism. …”
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  16. 216
    “…Almost 47 million people suffer from dementia worldwide, with an estimated new case diagnosed every 3.2 seconds. Alzheimer’s disease (AD) accounts for approximately 60%–80% of all dementia cases. …”
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  17. 217
    por Hao, Wenrui, Friedman, Avner
    Publicado 2016
    “…BACKGROUND: Alzheimer disease (AD) is a progressive neurodegenerative disease that destroys memory and cognitive skills. …”
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  18. 218
    por Khalsa, Dharma Singh, Perry, George
    Publicado 2017
    “…Much is yet to be discovered about the precise biological changes that cause Alzheimer’s, disease, why it progresses more quickly in some than in others, and how the disease can be prevented, slowed, or stopped. …”
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  20. 220
    “…BACKGROUND: Brain lesions in Alzheimer’s disease (AD) are characterized by Aβ accumulation, neurofibrillary tangles, and synaptic and neuronal vanishing. …”
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