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4461
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4462por Charles, Bashira A, Shriner, Daniel, Doumatey, Ayo, Chen, Guanjie, Zhou, Jie, Huang, Hanxia, Herbert, Alan, Gerry, Norman P, Christman, Michael F, Adeyemo, Adebowale, Rotimi, Charles N“…The purposes of this study were: 1) to replicate major signals reported in EA populations; and 2) to use the weak LD pattern in African ancestry population to better localize (fine-map) reported loci and 3) to explore the identification of novel findings cognizant of the moderate sample size. METHODS: African American (AA) participants (n = 1,017) from the Howard University Family Study were included in this study. …”
Publicado 2011
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4463
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4464por Haiman, Christopher A., Chen, Gary K., Blot, William J., Strom, Sara S., Berndt, Sonja I., Kittles, Rick A., Rybicki, Benjamin A., Isaacs, William B., Ingles, Sue A., Stanford, Janet L., Diver, W. Ryan, Witte, John S., Chanock, Stephen J., Kolb, Suzanne, Signorello, Lisa B., Yamamura, Yuko, Neslund-Dudas, Christine, Thun, Michael J., Murphy, Adam, Casey, Graham, Sheng, Xin, Wan, Peggy, Pooler, Loreall C., Monroe, Kristine R., Waters, Kevin M., Le Marchand, Loic, Kolonel, Laurence N., Stram, Daniel O., Henderson, Brian E.“…Through fine-mapping, we identified nearby markers in many regions that better define associations in African Americans. At 8q24, we found 9 variants (p≤6×10(−4)) that best capture risk of prostate cancer in African Americans, many of which are more common in men of African than European descent. …”
Publicado 2011
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4465por Zarini, Gustavo G, Exebio, Joel C, Gundupalli, Deva, Nath, Subrata, Huffman, Fatma G“…PURPOSE: To investigate to what degree the presence of hypertension (HTN) and poor glycemic control (GC) influences the likelihood of having microalbuminuria (MAU) among Cuban Americans with type 2 diabetes (T2D). METHODS: A cross-sectional study conducted in Cuban Americans (n = 179) with T2D. …”
Publicado 2011
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4466por Wall, Jeffrey D., Jiang, Rong, Gignoux, Christopher, Chen, Gary K., Eng, Celeste, Huntsman, Scott, Marjoram, Paul“…Analyses of genetic polymorphism data have the potential to be highly informative about the demographic history of Native American populations, but due to a combination of historical and political factors, there are essentially no autosomal sequence polymorphism data from any Native American group. …”
Publicado 2011
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4467por Maruthur, Nisa M., Kao, W.H. Linda, Clark, Jeanne M., Brancati, Frederick L., Cheng, Ching-Yu, Pankow, James S., Selvin, Elizabeth“…OBJECTIVE: Glycated hemoglobin (HbA(1c)) values are higher in African Americans than whites, raising the question of whether classification of diabetes status by HbA(1c) should differ for African Americans. …”
Publicado 2011
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4468por Kupfer, Sonia S., Anderson, Jeffrey R., Ludvik, Anton E., Hooker, Stanley, Skol, Andrew, Kittles, Rick A., Keku, Temitope O., Sandler, Robert S., Ruiz-Ponte, Clara, Castellvi-Bel, Sergi, Castells, Antoni, Carracedo, Angel, Ellis, Nathan A.“…Low vitamin D levels are associated with an increased incidence of colorectal cancer (CRC) and higher mortality from the disease. In the US, African Americans (AAs) have the highest CRC incidence and mortality and the lowest levels of vitamin D. …”
Publicado 2011
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4469por Cooke, Jessica N., Ng, Maggie C.Y., Palmer, Nicholette D., An, S. Sandy, Hester, Jessica M., Freedman, Barry I., Langefeld, Carl D., Bowden, Donald W.“…These SNPs have not been extensively investigated for individual and cumulative effects on T2D risk in African Americans. RESEARCH DESIGN AND METHODS: Seventeen index T2D risk variants were genotyped in 2,652 African American case subjects with T2D and 1,393 nondiabetic control subjects. …”
Publicado 2012
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4470por Delaney, Jessica T., Jeff, Janina M., Brown, Nancy J., Pretorius, Mias, Okafor, Henry E., Darbar, Dawood, Roden, Dan M., Crawford, Dana C.“…The contribution of these loci to AF risk in African American is unknown. METHODOLOGY/PRINCIPAL FINDINGS: We studied 73 African Americans with AF from the Vanderbilt-Meharry AF registry and 71 African American controls, with no history of AF including after cardiac surgery. …”
Publicado 2012
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4471por Sharma, Amit, Teigeler, Todd L., Behnke, Martha, Cotterell, Adrian, Fisher, Robert, King, Anne, Gehr, Todd, Posner, Marc“…When only the African American patients in the two groups were compared, there were no differences in graft or patient survival. …”
Publicado 2012
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4472
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4473por Adeyemo, Adebowale, Bentley, Amy R, Meilleur, Katherine G, Doumatey, Ayo P, Chen, Guanjie, Zhou, Jie, Shriner, Daniel, Huang, Hanxia, Herbert, Alan, Gerry, Norman P, Christman, Michael F, Rotimi, Charles N“…Studies of the transferability of these associations to African Americans remain few, an important limitation given interethnic differences in serum lipids and the disproportionate burden of lipid-associated metabolic diseases among African Americans. …”
Publicado 2012
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4474por Morris, Alanna A., Patel, Riyaz S., Binongo, Jose Nilo G., Poole, Joseph, Mheid, Ibhar al, Ahmed, Yusuf, Stoyanova, Neli, Vaccarino, Viola, Din‐Dzietham, Rebecca, Gibbons, Gary H., Quyyumi, Arshed“…BACKGROUND: Compared with whites, black Americans suffer from a disproportionate burden of cardiovascular disease (CVD). …”
Publicado 2013
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4475por Babbitt, Dianne M., Diaz, Keith M., Feairheller, Deborah L., Sturgeon, Kathleen M., Perkins, Amanda M., Veerabhadrappa, Praveen, Williamson, Sheara T., Kretzschmar, Jan, Ling, Chenyi, Lee, Hojun, Grimm, Heather, Thakkar, Sunny R., Crabbe, Deborah L., Kashem, Mohammed A., Brown, Michael D.“…African Americans have the highest prevalence of hypertension in the world which may emanate from their predisposition to heightened endothelial inflammation. …”
Publicado 2013
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4476por Wojczynski, Mary K, Li, Mingyao, Bielak, Lawrence F, Kerr, Kathleen F, Reiner, Alex P, Wong, Nathan D, Yanek, Lisa R, Qu, Liming, White, Charles C, Lange, Leslie A, Ferguson, Jane F, He, Jing, Young, Taylor, Mosley, Thomas H, Smith, Jennifer A, Kral, Brian G, Guo, Xiuqing, Wong, Quenna, Ganesh, Santhi K, Heckbert, Susan R, Griswold, Michael E, O’Leary, Daniel H, Budoff, Matthew, Carr, J Jeffrey, Taylor,, Herman A, Bluemke, David A, Demissie, Serkalem, Hwang, Shih-Jen, Paltoo, Dina N, Polak, Joseph F, Psaty, Bruce M, Becker, Diane M, Province, Michael A, Post, Wendy S, O’Donnell, Christopher J, Wilson, James G, Harris, Tamara B, Kavousi, Maryam, Cupples, L Adrienne, Rotter, Jerome I, Fornage, Myriam, Becker, Lewis C, Peyser, Patricia A, Borecki, Ingrid B, Reilly, Muredach P“…Coronary artery calcification (CAC) scores are independent predictors of CHD. African Americans (AA) have higher rates of CHD but are less well-studied in genomic studies. …”
Publicado 2013
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4477por Carless, Melanie A., Kulkarni, Hemant, Kos, Mark Z., Charlesworth, Jac, Peralta, Juan M., Göring, Harald H. H., Curran, Joanne E., Almasy, Laura, Dyer, Thomas D., Comuzzie, Anthony G., Mahaney, Michael C., Blangero, John“…In this paper, we examine the evidence for genetic effects on DNA methylation in a Mexican American cohort, a population burdened by a high prevalence of obesity. …”
Publicado 2013
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4478“…Two of these alleles that are found in African Americans—ALDH1A1*2 and ALDH1A1*3—may be associated with a reduced risk of alcoholism.…”
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4479“…Background. Native Americans disproportionately experience adverse childhood experiences (ACEs) as well as health disparities, including high rates of posttraumatic stress, depression, and substance abuse. …”
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4480por Bidulescu, Aurelian, Choudhry, Shweta, Musani, Solomon K., Buxbaum, Sarah G., Liu, Jiankang, Rotimi, Charles N., Wilson, James G., Taylor, Herman A., Gibbons, Gary H.“…Background: Compared with European Americans, African Americans (AAs) exhibit lower levels of the cardio-metabolically protective adiponectin even after accounting for adiposity measures. …”
Publicado 2014
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