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2481“…BV was bilaterally administered into a 98-day-old hSOD1(G93A) animal model. We found that BV-treated hSOD1(G93A) transgenic mice showed reduced detergent-insoluble polymerization and phosphorylation of α-synuclein. …”
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2482“…Human herpesvirus (HHV)-6A and HHV-6B are two enveloped DNA viruses of β-herpesvirus family, infecting over 90% of the population and associated with several diseases, including exanthema subitum (for HHV-6B), multiple sclerosis and encephalitis, particularly in immunosuppressed patients. Animal models are highly important to better understand the pathogenesis of viral infections. …”
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2483
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2484“…There is an urgent need for novel animal models to expand the range of current studies, most of which have been conducted in rodents. …”
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2485por Chen, Qiang, Ma, Yufang, Yang, Yumei, Chen, Zhenliang, Liao, Rongrong, Xie, Xiaoxian, Wang, Zhen, He, Pengfei, Tu, Yingying, Zhang, Xiangzhe, Yang, Changsuo, Yang, Hongjie, Yu, Fuqing, Zheng, Youmin, Zhang, Zhiwu, Wang, Qishan, Pan, Yuchun“…However, current NGS approaches are not easy to apply to general outbred populations (human and some major farm animals) for SNP identification because of the high level of heterogeneity and phase ambiguity in the haplotype. …”
Publicado 2013
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2486“…Animal models are generalized linear mixed models used in evolutionary biology and animal breeding to identify the genetic part of traits. …”
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2487“…The generation of disease-specific animal models, and the developments of target-specific probes and genetically encoded reporters are another important component. …”
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2488“…In conclusion, the zebrafish model not only enhances our understanding of body fluid ion homeostasis and hormonal control in fish but also informs studies on mammals and other animal species, thereby providing new insights into related fields.…”
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2489por Alves, Rômulo Romeu Nóbrega, Oliveira, Tacyana Pereira Ribeiro, Rosa, Ierecê Lucena“…In this study we interviewed 124 merchants and 203 traditional users of animal-derived remedies in Brazil, aiming at documenting the animal species used as foods and medicines in urban and rural areas of the country. …”
Publicado 2013
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2490“…This review article provides an outline of the clinical features of EHF and MHF in animals, including humans, and discusses how the animal models have been developed to study pathophysiology, vaccines, and therapeutics.…”
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2491“…In the near future, many animal models of human-specific infections and experimental data from high-throughput techniques will become available. …”
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2492por Kim, Sang-Woo, Kim, Kyoung-Shim, Solis, Chester D., Lee, Myeong-Seop, Hyun, Byung-Hwa“…Compared to sham, OVX animals have decreased blood OSC level, while the blood PTH level increased in blood sera. …”
Publicado 2013
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2493por Esamaeili, Saber, Azadmanesh, Kayhan, Naddaf, Saied Reza, Rajerison, Minoarisoa, Carniel, Elisabeth, Mostafavi, EhsanEnlace del recurso
Publicado 2013
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2494“…A plethora of magnetic resonance (MR) techniques developed in the last two decades provide unique and noninvasive measurement capabilities for studies of basic brain function and brain diseases in humans. Animal model experiments have been an indispensible part of this development. …”
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2495por Maeda, Koki, Hanajima, Dai, Toyoda, Sakae, Yoshida, Naohiro, Morioka, Riki, Osada, Takashi“…Composting is the major technology in the treatment of animal manure and is a source of nitrous oxide, a greenhouse gas. …”
Publicado 2011
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2496“…In this review we summarize findings from animal and human studies that have investigated the involvement of striatal DA in cognitive flexibility. …”
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2497“…Calculation of sample size is one of the important component of design of any research including animal studies. If a researcher select less number of animals it may lead to missing of any significant difference even if it exist in population and if more number of animals selected then it may lead to unnecessary wastage of resources and may lead to ethical issues. …”
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2498“…We also describe and compare the pathological presentations, in both morphological and functional aspects, of the currently available DR animal models. The advantages and disadvantages of using different animals, ranging from zebrafish, rodents to other higher-order mammals, are also discussed. …”
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2499“…Thus, cell therapy of periodontium has been assessed in many animal models and promising results have been reported. …”
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2500“…Our systematic research in animals indicated that airway reflexes have similar resuscitation potential as gasping respiration. …”
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