“…In this study here, we investigated further the impact of the role of interleukin-10 on the NFκB pathway and its targets within the gut using a whole animal approach, and confirmed that NFκB activation is indeed positively regulated by interleukin-10, affecting the expression of downstream target genes and their encoded proteins. …”
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“…In conclusion, the use of E. faecium (isolated and commercial) at 2 g/kg DM of feed improved feed efficiency and production performance, with superior effects on animal performance from isolated E. faecium compared to the commercial one.…”
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“…One of the main problems in the animal industries currently is the constant provision of forage in sufficient amounts with acceptable nutritional content for large and small ruminants, as livestock is a significant source of income for rural people in the Loess Plateau region. …”
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“…BACKGROUND: African trypanosomosis is a disease of both animals and humans resulting from infection with parasitaemic protozoa of the genus Trypanosoma transmitted mainly by the tsetse flies (Glossina species). …”
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“…Cows from one dairy farm (n = 246) located in central Pennsylvania were included in this study. Animals were blocked by parity and randomly assigned to 1 of 2 groups: (1) ASA (n = 121): within ~12 h after parturition, cows received 2 treatments with acetylsalicylic acid (ASA; 200 mg/kg, 4 boluses) 24 h apart; or (2) UNT (n = 125): cows remained untreated. …”
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“…In addition, we assayed for emetic response in the musk shrew, with little to no such emesis displayed (n=8) for GEP44 (1/8), but emesis noted across all animals tested for Ex4. During 11 d of treatment with GEP44, FI was consistently reduced resulting in a significantly stronger reduction of BW compared to Ex4 at the end of treatment (GEP44 -7.6%, Ex4 -3.7%, p<0.05). …”
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“…Therefore, we investigated the effect LNG had on neuroendogenesis in zebrafish (Danio rerio), an established comparative neurobiological animal model. Fertilized zebrafish embryos were collected (in-house breeding) and individually placed in 96-well plates. …”
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“…In vivo efficacy studies of HM15136 in animal models showed its therapeutic potential in obesity, and treatment requiring hypoglycemia. …”
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“…Furthermore, it has been reported that adrenal steroidogenesis increases in db/db mice, an animal model of type 2 diabetes. However, the mechanism of the increased adrenal steroidogenesis in type 2 diabetes is unclear. …”
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“…Thus, when treating disorders of metabolic dysfunction (e.g., obesity, type II diabetes, neurodegenerative disease), a pharmacotherapeutic strategy that modulates 'biased' GHSR1a signaling may uncouple desired therapeutic outcomes from unwanted side effects. For example, animal models bearing G protein- or βarr-biasing GHSR1a mutations may express differences in orexigenic and glucoregulatory effects that are signaling pathway-dependent, and our group has demonstrated that GHSR1a antagonism blunts cocaine-induced neuroadaptive behaviors via a mechanism requiring βarr2 in dopaminergic neurons (Toth et al., 2016, Synapse). …”
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“…Also compatible with the growing popularity of animal-component-free studies, this xeno-free B-27/SH-SY5Y culture system will be a valuable tool to boost the translational potential of preliminary studies requiring glutamatergic neuronal cells of human origin.…”
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“…Livestock animals, such as swine, are an important source of Toxoplasma gondii in the human population. …”
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“…The control group and the model group were treated with saline or BAR. The animals were sacrificed 12 hours after the last administration. …”
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“…The in vivo studies go beyond the molecular level by showing significant reduction of the tumor growth and volume in animal models. Additionally, we present data regarding plant-mediated biosynthesis of nanoparticles, which is regarded as a new branch in plant latex research. …”
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