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“…The in vivo tests were performed in 140 healthy Wister albino rats of either sex under well-controlled parameters divided into 14 groups, strictly maintaining Institutional Animal Ethics Committee (IEAC) protocols. For the histopathology study, 10% buffered neutral formalin was used for organ preservation. …”
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“…Methods: Female Wistar rats were submitted to stereotaxic surgery for implantation of a guide cannula into the mPOA 7 days prior to the experiments. Afterwards, the animals were isoflurane- anesthetized and submitted to the catheterization of the femoral artery and vein and urinary bladder cannulation for mean arterial pressure (MAP), heart rate (HR), and intravesical pressure (IP) recordings, respectively. …”
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“…Given this situation, microalgae have received special attention due to their broad nutritional attributes, ecological benefits, and some species’ high digestibility, indicating that they have the potential to be used as a feed supplement in animal nutrition. Interestingly, some studies have revealed that microalgae have the potential to reduce methanogenesis in cattle, and the findings of this study demonstrated that indeed; the use of marine microalgae as a feed additive has positive effects on biogas, CH(4), and H(2)S mitigation in sheep. …”
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“…Studies show that there may be unbalanced ovarian hormonal levels and decreased ovarian function in young female cancer survivors, however, limited studies have explained the mechanism of medication-induced ovarian toxicity in an animal model. This study aimed to investigate the gonadotoxic effects of CY and BU in CD-1 strain mice and to delineate the underlying mechanism of the gonadotoxic outcomes, eventually suggesting possible fertoprotectants for HSCT recipients’ fertility preservation.Sixteen one-month-old female CD-1 mice (n=4/group) were subcutaneously injected with solvent, BU, CY, or BU+CY, respectively, over the course of six days. …”
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“…Our method is amenable to 3D organoid formation and pre-clinical implantation in animal models of hypophysectomy as a novel hormone replacement therapy. …”
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“…Follicles, the functional unit of the ovary with the potential to develop into mature eggs, are composed of a single germ cell and somatic support cells (i.e., granulosa and theca cells). While animal studies have demonstrated a positive effect of ovarian stromal cells to follicle development, the ovarian stromal compartment remains largely undescribed. …”
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“…We developed an experimental animal model that imitates sedentary behavior in which a chromatin epigenetic landscape could be explored. …”
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“…GLP-1 effect on small intestinal motility is not extensively studied, however, small bowel motility inhibition was noted in animal models. Some of these actions were dose-dependent. …”
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“…Finally, diaphragm contractile force and motion parameters (excursion amplitude, inspiratory velocity, and expiratory velocity) declined with duration of obesity in WT mice, but, remained unchanged in Thbs1(-/-) animals. These data define THBS-1 as a novel regulator of diaphragm stromal remodeling and potential therapeutic target for mitigating obesity-associated respiratory dysfunction. …”
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“…We have found that knockout (KO) of PARP1 in the monocyte/macrophage lineage (i.e., using a LysM-Cre driver) results in dramatic weight gain in mice with a nearly 2-fold increase in fat body mass in animals fed a high fat diet. Further analysis revealed decreases in adipose-associated macrophages and adipose hypertrophy, as well as increased hepatic lipid accumulation. …”
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“…However, abnormally elevated androgen levels reduce fertility in humans and animals, suggesting that a delicate equilibrium exists between the beneficial and harmful effects of androgens in the ovary. …”
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“…Importantly, RO (20-40 mg/kg/day; ip) significantly suppressed tumor xenografts derived from ovarian cancer cells (SK-OV-3; 336 + 60 mm(3) vs 171 + 20 mm(3)) with no toxicity to experimental animals (27 treatments once tumors reached 100 mm(3)). …”
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“…On day 16, 400 I.U. of pregnantmare serum gonadotropin and 200 I.U of human chorionic gonadotropin (PG600®,Merck Animal Health) were administered intramuscularly to stimulatefolliculogenesis and ovulation. …”
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“…The exact mechanism is uncertain, and the evidence is based on experimental animal models, but it is believed that the effects on the brain are due to increased dopamine levels and tyrosine hydroxylase activity in hypothyroid patients, mostly in the limbic system where most emotional and behavioral responses are processed. …”
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“…Gestational hyperandrogenism such as that seen in Polycystic Ovary Syndrome (PCOS), leads to adverse offspring health outcomes in both humans and animals. Prenatal T excess (T) in a sheep model of PCOS phenotype induces peripheral insulin resistance, dyslipidemia, adipocyte defects, liver steatosis, pathological cardiac remodeling and hypertension in the female offspring. …”
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“…To identify the role of unhypusinated eIF5A, we used the following animal and cell-based models: RNAi knockdown and transgenic zebrafish; inducible, β cell-specific knockout mice fed a high fat diet; and cultured HEK-293 cells. …”
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