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258021“…The reserve stores of blood protein-producing materials are thus largely depleted in such animals and sustained levels of 6 to 8 gm. per cent hemoglobin and 4 to 5 gm. per cent plasma protein can be maintained for considerable periods of time. …”
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258022por Bhakdi, S, Muhly, M, Mannhardt, U, Hugo, F, Klapettek, K, Mueller-Eckhardt, C, Roka, L“…That α toxin represents an important factor of staphylococcal pathogenicity has been clearly established in several models of animal infections through the use of genetically engineered bacterial strains deleted of an active α toxin gene (25-27). …”
Publicado 1988
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258023“…It was also found that, in contrast to similar preparations from certain other animal tissues, the Arbacia cytochrome oxidase preparation displayed no succinic dehydrogenase activity when tested manometrically in the presence of excess cytochrome c. 5. …”
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258024“…A decrease in NO synthesis in animal models of seizure and radiation injury may account for the anticonvulsant, radioprotectant, and radiorecovery activities of Mn(3)(3,5-DIPS)(6) and Cu(II)(2)(3,5-DIPS)(4).…”
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258025por Lutz, Amelie M, Willmann, Juergen K, Cochran, Frank V, Ray, Pritha, Gambhir, Sanjiv S“…One of the limitations of the study is the absence of quantitative data available in the literature on the secreted tumor biomarker amount per cancer cell in intact whole body animal tumor models or in cancer patients. Additionally, the fraction of secreted tumor biomarkers actually reaching the plasma is unknown. …”
Publicado 2008
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258026por Petrushina, Irina, Ghochikyan, Anahit, Mkrtichyan, Mikayel, Mamikonyan, Grigor, Movsesyan, Nina, Ajdari, Rodmehr, Vasilevko, Vitaly, Karapetyan, Adrine, Lees, Andrew, Agadjanyan, Michael G, Cribbs, David H“…Vaccination with mannan-Aβ(28 )prevented Aβ plaque deposition, but unexpectedly increased the level of microhemorrhages in the brains of aged immunized mice compared to two groups of control animals of the same age either injected with molecular adjuvant fused with an irrelevant antigen, BSA (mannan-BSA) or non-immunized mice. …”
Publicado 2008
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258027“…We demonstrate for the first time, to our knowledge, the utility of the tethered-toxin technology in a transgenic animal, validating four different tethered spider toxin ion channel modifiers for use in Drosophila. …”
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258028por Liu, J., Saghizadeh, M., Tuli, S.S., Kramerov, A.A., Lewin, A.S., Bloom, D.C., Hauswirth, W.W., Castro, M.G., Schultz, G.S., Ljubimov, A.V.“…After seven days to allow for corneal healing and gene expression the animals were euthanized, the corneas were excised, and sections analyzed by immunohistochemistry. …”
Publicado 2008
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258029“…PURPOSE: To investigate senescent evidence in corneal endothelial cells (CECs) of the senescence-accelerated mouse (SAM), which is considered a suitable animal model for the further study of the senescent mechanism in CECs. …”
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258030por Fu, Wen, McCormick, Tom, Qi, Xiaoping, Luo, Liping, Zhou, Lingyin, Li, Xin, Wang, Bing-Cheng, Gibbons, Heidi E, Abdul-Karim, Fadi W, Gorodeski, George I“…At the completion of study (week 28) the proportion of living animals with cancers in the DMBA/TPA group was 100% compared to 43% in the DMBA/TPA+BzATP group. …”
Publicado 2009
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258031por Nayak, Debi P., Balogun, Rilwan A., Yamada, Hiroshi, Zhou, Z. Hong, Barman, Subrata“…Morphogenesis and budding require that all virus components must be brought to the budding site which is the apical plasma membrane in polarized epithelial cells whether in vitro cultured cells or in vivo infected animals. HA and NA forming the outer spikes on the viral envelope possess apical sorting signals and use exocytic pathways and lipid rafts for cell surface transport and apical sorting. …”
Publicado 2009
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258032“…We used computer graphics such as model-based visualization (i.e. 3D numerical modelling using finite element method) and 3D computer animations and graphical illustrations to facilitate the representation of complex biological and physical aspects in electrochemotherapy. …”
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258033por Pedrini, Steve, Thomas, Carlos, Brautigam, Hannah, Schmeidler, James, Ho, Lap, Fraser, Paul, Westaway, David, Hyslop, Peter St George, Martins, Ralph N, Buxbaum, Joseph D, Pasinetti, Giulio M, Dickstein, Dara L, Hof, Patrick R, Ehrlich, Michelle E, Gandy, Sam“…At age 18 wks, mice were sacrificed, and brains studied for (a) wet weight; (b) solubilizable Aβ content by ELISA; (c) amyloid plaque burden; (d) stereologic analysis of selected hippocampal subregions. RESULTS: Animals receiving a high fat diet showed increased brain levels of solubilizable Aβ, although we detected no effect on plaque burden. …”
Publicado 2009
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258034“…Testing for differences in gene expression between the two ages (30 versus 42 days), 54 genes were differently expressed in wild-type mice and 215 genes in homozygous animals. Based on three networks proposed by Ingenuity pathway analysis software, nine differently expressed genes in the homozygous Egr-1 knockout mice were chosen for further validation by real-time RT–PCR, three genes in each network. …”
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258035por Amann, Anton, Klotz, Andreas, Niederklapfer, Thomas, Kupferthaler, Alexander, Werther, Tobias, Granegger, Marcus, Lederer, Wolfgang, Baubin, Michael, Lingnau, Werner“…The VF-ECGs were mixed with 12 different ECG-CPR-artifacts recorded in an animal experiment during asystole. The length of each of the ECG-data was chosen to be 20 sec, and testing was done for all 168 = 14 × 12 pairs of data. …”
Publicado 2010
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258036por Zivkovic, Zorica, Torina, Alessandra, Mitra, Ruchira, Alongi, Angela, Scimeca, Salvatore, Kocan, Katherine M, Galindo, Ruth C, Almazán, Consuelo, Blouin, Edmour F, Villar, Margarita, Nijhof, Ard M, Mani, Rinosh, La Barbera, Giuseppa, Caracappa, Santo, Jongejan, Frans, de la Fuente, José“…BACKGROUND: Ticks (Acari: Ixodidae) are vectors of pathogens worldwide that cause diseases in humans and animals. Ticks and pathogens have co-evolved molecular mechanisms that contribute to their mutual development and survival. …”
Publicado 2010
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258037por Muzzarelli, Riccardo A. A.“…Said articles, that devote attention to the safety and biocompatibility aspects, never reported intolerance or allergy in individuals and animals, even when the quantities of chitosan used in single experiments were quite large. …”
Publicado 2010
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258038por Sampson, Mariam, Archibong, Anthony E., Powell, Adriane, Strange, Brandon, Roberson, Shannon, Hills, Edward R., Bourne, Phillip“…Women are advised not to attempt pregnancy while on hydroxyurea (HU) due to the teratogenic effects of this agent, based on results obtained from animal studies. Several case reports suggest that HU may have minimal or no teratogenic effects on the developing human fetus. …”
Publicado 2010
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258039por Brown, Kemar, Legros, Stephanie, Artus, Jérôme, Doss, Michael Xavier, Khanin, Raya, Hadjantonakis, Anna-Katerina, Foley, Ann“…First, because endodermal organs, such as the liver and pancreas, play important physiological roles in adult animals, much experimental effort has been directed in recent years toward the establishment of protocols for the efficient derivation of endodermal cell types in vitro. …”
Publicado 2010
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258040por Branco, Luis M, Grove, Jessica N, Geske, Frederick J, Boisen, Matt L, Muncy, Ivana J, Magliato, Susan A, Henderson, Lee A, Schoepp, Randal J, Cashman, Kathleen A, Hensley, Lisa E, Garry, Robert F“…These studies highlight the relevance of a VLP platform for designing an optimal vaccine candidate against Lassa hemorrhagic fever, and warrant further investigation in lethal challenge animal models to establish their protective potential.…”
Publicado 2010
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