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  1. 258901
    “…Neurobiol, 2016; 40: 72–80) proposed that the relatively continuous beta-synchronisation observed in trial-averaged data may reflect the probability distribution of transient beta events discernible in single trial data. She cited both animal and human data consistent with a neural model in which these beta bursts are generated by transient input to pyramidal neurons via distal dendrites concurrent with input to deeper layers presumed to be from thalamus. …”
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    T144. THE ROLE OF TRANSIENT BETA OSCILLATIONS IN ABERRANT SELECTIVE ATTENTION TO SALIENT EVENTS IN SCHIZOPHRENIA
  2. 258902
    “…DISCUSSION: GPR52 agonists were efficacious in animal models assessing the three main symptoms domains associated with schizophrenia. …”
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    T40. GPR52 AGONISTS REPRESENT A NOVEL APPROACH TO TREAT UNMET MEDICAL NEED IN SCHIZOPHRENIA
  3. 258903
    “…Evenamide shows efficacy in animal models of SCZ as monotherapy and as an add-on to FGA or SGA, irrespective of whether impairment was spontaneous, or induced by amphetamine, NMDAr antagonists or stress. …”
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    T48. ANTIPSYCHOTIC EFFICACY OF EVENAMIDE (NW-3509) IS DUE TO MODULATION OF GLUTAMATERGIC DYSREGULATION
  4. 258904
    por Kokkinou, Michelle, Howes, Oliver
    Publicado 2018
    “…METHODS: All procedures were conducted under licence in accordance with the UK Animals (Scientific Procedures) Act of 1986. Mice received a sub-anaesthetic dose of ketamine or an equivalent volume of saline for five consecutive days. …”
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    O7.1. MIDBRAIN DOPAMINE NEURON ACTIVITY CONTROLS THE EFFECTS OF REPEATED KETAMINE ON STRIATAL DOPAMINERGIC FUNCTION
  5. 258905
    “…The VR-based computer game and DFAR were developed in-house with Autodesk Maya 3D animation and Unity software (unity3d.com). RESULTS: Patients’ emotion recognition accuracy (BLERT) significantly improved from pre- to post-training. …”
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    T205. CHANGES IN SOCIAL ATTENTION AND EMOTION RECOGNITION FOLLOWING A PILOT SOCIAL SIMULATION COMPUTER GAME INTERVENTION FOR INDIVIDUALS WITH SCHIZOPHRENIA
  6. 258906
    “…BACKGROUND: Accumulated evidence from non-human animal studies suggests that the prominent deficits in memory and executive function that characterise individuals with psychosis may, at least in part, be due to the effects of stress on the brain regions that support these functions. …”
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    O9.8. STRESS AND COGNITIVE FUNCTION AMONG INDIVIDUALS AT CLINICAL HIGH-RISK FOR PSYCHOSIS: FINDINGS FROM THE NAPLS COHORT
  7. 258907
    por Mellor, David J.
    Publicado 2018
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    Tail Docking of Canine Puppies: Reassessment of the Tail’s Role in Communication, the Acute Pain Caused by Docking and Interpretation of Behavioural Responses
  8. 258908
    “…METHOD: This study was performed in the animal lab approved by the Ethics Committee of Tehran University of Medical Sciences in 2014, on 25 male Wistar rats. …”
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    An Analysis of the Hypothalamic-Pituitary-Adrenal Axis Functions in Cirrhotic Rats in Response to Surgical Stress
  9. 258909
    “…Plastin 3 (PLS3) and neurocalcin delta (NCALD) are two SMN-independent protective modifiers identified in humans and proved to be effective across various SMA animal models. Both PLS3 overexpression and NCALD downregulation protect against SMA by restoring impaired endocytosis; however, the exact mechanism of this protection is largely unknown. …”
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    CHP1 reduction ameliorates spinal muscular atrophy pathology by restoring calcineurin activity and endocytosis
  10. 258910
    “…Four weeks following injury, a surgical repair was performed in the CR and ER groups using transosseous suture fixation with human amniotic membrane applied to the tendon-bone repair site in the ER group. Animals were euthanized at four weeks following the repair. …”
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    Human Amniotic Membrane Improves Healing in a Chronic, Massive Rotator Cuff Repair Model
  11. 258911
    “…There was a marked increase in hippocampal microdialysate glutamate levels after local NaHS infusion in LPS untreated animals. In LPS treated rats, no change was observed by NaHS, but LPS itself had the strongest effect on microdialysate glutamate levels. …”
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    Hydrogen Sulfide Affects Radical Formation in the Hippocampus of LPS Treated Rats and the Effect of Antipsychotics on Hydrogen Sulfide Forming Enzymes in Human Cell Lines
  12. 258912
    “…Here we review genetic, genomic, cellular, postmortem, animal model, and cell model evidence that shows ASD begins in the womb. …”
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    The ASD Living Biology: from cell proliferation to clinical phenotype
  13. 258913
    “…In addition, strong correlations have been reported between splenic stiffness values measured with MRE and hepatic venous pressure gradients in animal models. However, most studies have been conducted on adult populations, and previous pediatric MRE studies have only demonstrated the feasibility of MRE in pediatric populations, while the actual clinical application of spleen MRE has been limited. …”
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    Predicting gastroesophageal varices through spleen magnetic resonance elastography in pediatric liver fibrosis
  14. 258914
    “…AIM: To evaluate the protective effects of TEMPOL on oxidative stress, inflammation, tissue injury, and renal hemodynamics and oxygenation in a clinically representative rat model of I/R using aortic cross-clamping. METHODS: Animals (N = 24) were either sham-operated or subjected to ischemia (30 min) and 90-min reperfusion, with or without TEMPOL treatment (15 min before ischemia and during entire reperfusion phase, 200 μmol/kg/h). …”
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    TEMPOL has limited protective effects on renal oxygenation and hemodynamics but reduces kidney damage and inflammation in a rat model of renal ischemia/reperfusion by aortic clamping
  15. 258915
    “…CONCLUSIONS/INTERPRETATION: The present study identifies a deterioration of beta cell function and mass, and intra-islet blood flow that precedes insulitis and diabetes development in animals prone to autoimmune type 1 diabetes. These underlying changes in islet function may be previously unrecognised factors of importance in type 1 diabetes development. …”
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    Early deficits in insulin secretion, beta cell mass and islet blood perfusion precede onset of autoimmune type 1 diabetes in BioBreeding rats
  16. 258916
    “…Corrections greatly reduced variations in preclinical MBF maps as obtained in normal animals without obstruction (FFR = 1). Coefficients of variations were 22% (conventional CT), 9% (ABHC), and 5% (virtual keV). …”
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    Calibration‐free beam hardening correction for myocardial perfusion imaging using CT
  17. 258917
    “…Increases in muscle force caused by FOR (WT, 24%, P ≤ 0.05) were only partially impaired in MKR mice (12%, P ≤ 0.05), and FOR‐induced slow‐to‐fast fibre type shift was not blocked at all in these animals. In MKR mice, FOR also restored the lower levels of muscle SDH activity to basal WT values and caused a marked reduction (57%, P ≤ 0.05) in the number of centrally nucleated fibers. …”
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    Insulin/IGF1 signalling mediates the effects of β(2)‐adrenergic agonist on muscle proteostasis and growth
  18. 258918
    “…We have found consistently that responses of cells or whole animals to drug-dose stimulations fit a parabolic response surface (PRS), allowing us to identify and optimize the best drug combinations by testing only a small fraction of the total search space. …”
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    Artificial intelligence enabled parabolic response surface platform identifies ultra-rapid near-universal TB drug treatment regimens comprising approved drugs
  19. 258919
    “…Drug treatments did not significantly affect animal weight nor alter serum calcium, alkaline phosphatase or N-terminal propeptide of Type 1 procollagen (PN1P) bone formation marker. …”
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    OR30-4 Parathyroid Hormone-related Peptide Antagonist and Inverse Agonist Reduce Breast Cancer Metastasis to Bone and Bone Loss
  20. 258920
    “…BACKGROUND: Polycomb group (PcG) proteins play important roles in animal and plant development and stress response. …”
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    Evolution and conservation of polycomb repressive complex 1 core components and putative associated factors in the green lineage
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