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258941por Cheung, Wai W., Hao, Sheng, Wang, Zhen, Ding, Wei, Zheng, Ronghao, Gonzalez, Alex, Zhan, Jian‐Ying, Zhou, Ping, Li, Shiping, Esparza, Mary C., Hoffman, Hal M., Lieber, Richard L., Mak, Robert H.“…CONCLUSIONS: We report the novel findings that correction of 25(OH)D(3) and 1,25(OH)(2)D(3) insufficiency reverses cachexia and may improve quality of life by restoring muscle function in an animal model of infantile nephropathic cystinosis. …”
Publicado 2019
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258942por Jodeleit, Henrika, Milchram, Lisa, Soldo, Regina, Beikircher, Gabriel, Schönthaler, Silvia, Al-amodi, Omar, Wolf, Eckhard, Beigel, Florian, Weinhäusel, Andreas, Siebeck, Matthias, Gropp, Roswitha“…In an inflammatory environment, auto-antibodies may promote the pathological phenotype by activating M1 monocytes in the NSG-UC animal model and also in patients with UC.…”
Publicado 2020
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258943
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258944por Rodrigues, Lima, Amezcua, Rocio, Cassar, Glen, O’Sullivan, Terri L, Friendship, RobertEnlace del recurso
Publicado 2020
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258945por Pu, Xuanxuan, Guo, Xuefeng, Shahzad, Khuram, Wang, Mengzhi, Jiang, Chenyu, Liu, Junfeng, Zhang, Xiuping, Zhang, Sujiang, Cheng, LongEnlace del recurso
Publicado 2020
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258946por Chen, Biao, Liang, Guitao, Zhu, Xuenong, Tan, Yuwen, Xu, Jiguo, Wu, Hongxiang, Mao, Huirong, Zhang, Yutao, Chen, Jiakun, Rao, Yousheng, Zhou, Min, Liu, SanfengEnlace del recurso
Publicado 2020
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258947por Plagemann, P. G. W.“…Chimpanzees and marmosets are the only animals found to be experimentally infectable and the virus has not been propagated in any cell culture system. …”
Publicado 1991
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258948por Abraham, Rachy, Mudaliar, Prashant, Jaleel, Abdul, Srikanth, Jandhyam, Sreekumar, Easwaran“…Several research groups work to understand the pathogenesis of chikungunya and the mechanisms of complications using cellular and animal models. A few proteomics approaches have been employed earlier to understand the protein level changes in the infected cells. …”
Publicado 2015
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258949por Tei, Matteo Maria, Placella, Giacomo, Sbaraglia, Marta, Tiribuzi, Roberto, Georgoulis, Anastasios, Cerulli, Giuliano“…The structural properties of the femur–ACL graft–tibia complex, from animals sacrificed at 8 weeks postoperatively, were determined using uniaxial tests. …”
Publicado 2020
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258951por Alonso, Aldara Martin, Cork, Simon C, Ma, Yue, Arnold, Myrtha, Herzog, Herbert, Bloom, Stephen R, Distaso, Walter, Murphy, Kevin Graeme, Salem, Victoria“…Feeding behaviour over 10 days in metabolic cages and the effects of endogenously released (after oral gavage of a nutrient bolus) or exogenously-administered PYY(3-36) were investigated. Results: NG-Y2R-KD animals had 60% reduction in NG Y2R mRNA but remained responsive to cholecystokinin, a positive control of vagal functionality. …”
Publicado 2020
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258952por Elias, Felipe Martins, Gomes, Nathalia Lisboa, Nishi, Mirian Yumie, Batista, Rafael Loch, Bissegatto, Debora Delmonte, Sircili, Maria Helena, Ferrari, Maria Tereza, Costa, Elaine Maria Frade, Mendonca, Berenice Bilharinho, Domenice, Sorahia“…The ZEB1 upregulation in penile tissue is positively correlated with the severity of hypospadias in animal models and humans. In the present study, 46,XY DSD patients with severe genital undervirilization had lower miR-200c expression in plasma. …”
Publicado 2020
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258953por Thaker, Vidhu V, Seaby, Eleanor G, Genetti, Casie, Sutherland, Jacob, Ianello, Grazia, Rajabi, Farrah, Schreiber, John M, Doege, Claudia A, Turer, Emre E, Hirschhorn, Joel N, Agrawal, Pankaj B“…Null mutations in Arnt2 in animals are not viable, but hypomorphic mutation results in hyperphagic obesity and its associated consequences (1). …”
Publicado 2020
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258954“…The study was continued until 15 surviving animals per time cohort were reached (n=120). We quantified pituitary pro-opiomelanocortin (POMC) gene/protein expression and POMC plasma concentrations, pituitary POMC intracellular trafficking and cleavage via intracellular POMC sorting/trafficking receptor Carboxypeptidase E (CPE) and prohormone convertase 1 (PC1/3) gene/protein expression. …”
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258955por Yu, Elaine Wei-Yin, Liu, Gao, Stastka, Petr, Cheney, Michael Chadwick, Mahabamunuge, Jasmin, Soto, Mariam Torres, Ford, Christopher B, Bryant, Jessica A, Henn, Matthew R, Hohmann, Elizabeth L“…Background: There is intense interest about the therapeutic potential of altering gut microbiota to improve metabolism, based primarily on intriguing animal studies. One prior trial of fecal microbiota transplantation (FMT) in obese men found that improved metabolic response after FMT was predicted by low baseline microbiome diversity. …”
Publicado 2020
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258956por Silswal, Neeru, Gupta, Herschel, Bean, Joe, Burale, Suban, Franks, Alexis, Berry, Kimberly J, Carey, Tricia, Oakley, Robert H, Cidlowski, John, Defranco, Donald, Monaghan, Ann Paula“…Significant evidence has accumulated in human and animal models that prenatal exposure to sGCs can lead to adverse side effects such as reduced birthweight, increased risk for hypertension, cardiovascular, metabolic, and neurological problems later in life. …”
Publicado 2020
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258957por Molina, Rogelio Enrique, Shao, Tiffany, Randhawa, Harmanprit, Hoang, Vanessa, Vyas, Arpita Kalla“…A subgroup of the control and DHT treated rats (n=6 per group) received a 0.84 g/kg dose of resveratrol (RSV) in their chow starting at age 5 weeks. At 8 weeks, animals were weighed weekly (n=6 per group). Oral glucose tolerance test (OGTT n=6 per group) and cardiac echocardiogram (C n=12, C+RSV n=6, DHT n=10, DHT+RSV n=6) were conducted at 16-weeks of age. …”
Publicado 2020
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258958por Sakamoto, Kenichi, Zhou, Chunxue, Maurizi, Giulia, Liberini, Claudia, Li, Ling, Ruiz, Henry H, Buettner, Christoph“…However, the role of the sympathetic nervous system (SNS) and catecholaminergic signaling in metabolic disease has not been well defined in large part due to a lack of suitable animal models(1). Surgical denervation is not specific to the SNS and chemical sympathectomy through 6-hydroxydopamine causes inflammation due to toxic effects. …”
Publicado 2020
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258959por Rosenbrock, Holger, Kroker, Katja, Stierstorfer, Birgit, Hobson, Scott, Arban, Roberto, Dorner-Ciossek, Cornelia“…In fact, it has previously been shown that either PDE2 or PDE9 inhibition increases synaptic plasticity, as determined by hippocampal long-term potentiation (LTP), and improves memory performance in animal cognition tasks. However, the exact sub-cellular localization of PDE2 and PDE9 enzymes in neurons is not fully established. …”
Publicado 2020
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258960por Carter, Cameron, Lesh, Tyler, Iosef, Ana-Maria, Tanase, Costin, Vaslova, Rosa, Styner, Martin, Maddock, Richard, Bauman, Melissa“…METHODS: Fourteen pregnant rhesus monkeys (Macaca mulatta) received polyICLC and 14 control animals have been scanned prospectively from both to their current age of 3.5 years. …”
Publicado 2020
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