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  1. 259441
    “…Suppression of Dicer, an endoribonuclease that regulates microRNAs(miRNA), has evolved as a viral mechanism to enhance host HIV infectivity and may have unintended metabolic consequences. Animal knockout models of adipose-specific dicer(ADicer) acquire lipodystrophy accompanied by severe metabolic abnormalities. …”
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    MON-100 Unique miRNA Signature in HIV Lipodystrophy with Reduced Adipose Dicer Expression
  2. 259442
    “…Once the TuV reached 100 mm(3), we randomized the animals for EB1089 (n=5; 0.8mcg/kg BW) or vehicle [Control group (CG) n=5; 80% propylene glycol-20% PBS] treatment (sc injection; 5 days/week during 5 weeks). …”
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    SAT-353 The Synthetic Vitamin D Analog EB1089 Restricts Adrenocortical Tumor Proliferation in NCI-H295 Xenograft Model
  3. 259443
    “…J Endocrinol 2018) that there is no established animal model to investigate GC effects on skeletal development. …”
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    SAT-530 Establishment of a Glucocorticoid (GC) Regimen to Induce Both Growth Retardation and Osteoporosis in C57BL/10 Muscular Dystrophy Mouse Models
  4. 259444
    “…This study was approved by the Experimental Animal Ethics Committee of Shandong University of China in April 2016 (approval No. …”
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    Ginsenoside Rb1 protects dopaminergic neurons from inflammatory injury induced by intranigral lipopolysaccharide injection
  5. 259445
    “…BACKGROUND: Pigs have emerged as one of the most popular large animal models in biomedical research, which in many cases is considered as a superior choice over rodent models. …”
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    Generation of pig induced pluripotent stem cells using an extended pluripotent stem cell culture system
  6. 259446
    “…HCPs experienced the OneTouch Verio Reflect glucose meter and the OneTouch Reveal mobile app online from their own office computers using interactive demonstrations via webpages and multiple animations. After providing demographic and clinical practice insights, HCPs responded to statements about the utility of the system. …”
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    Health Care Professionals’ Clinical Perspectives and Acceptance of a Blood Glucose Meter and Mobile App Featuring a Dynamic Color Range Indicator and Blood Sugar Mentor: Online Evaluation in Seven Countries
  7. 259447
    “…This suggested that our materials were safe and could be applied as a type of potential biomaterial in the future. 6) Further animal studies demonstrated that the implant was in good position without dislocation. …”
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    3D printed zirconia ceramic hip joint with precise structure and broad-spectrum antibacterial properties
  8. 259448
    “…A consortium of cultured ecogroup taxa, introduced into gnotobiotic piglets, reenacted changes in their relative abundances that were observed in human communities as the animals transitioned from exclusive milk feeding to a fully weaned state consuming a prototypic Bangladeshi diet. …”
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    A sparse covarying unit that describes healthy and impaired human gut microbiota development
  9. 259449
    “…Furthermore, the available material does not provide clear information on the ventral organization of this animal, obscuring our understanding of phylogenetically significant details such as the appendages. …”
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    The appendicular morphology of Sinoburius lunaris and the evolution of the artiopodan clade Xandarellida (Euarthropoda, early Cambrian) from South China
  10. 259450
    “…This is the first report of exercise protection in an adult adRP animal model. It is also the first report of an RPE phenotype in the I307N Rho mouse. …”
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    Wheel running exercise protects against retinal degeneration in the I307N rhodopsin mouse model of inducible autosomal dominant retinitis pigmentosa
  11. 259451
    “…In continuing our studies, we have generated a transgenic mouse endogenously expressing the ETV6 P214L mutation by CRISPR/Cas9 editing, and these mice appear to have a thrombocytopenic phenotype similar to that observed in patients carrying the ETV6 P214L mutation. These animals will be the focus of our continued investigation of the mechanism by which ETV6 germline mutation results in a predisposition to leukemia. …”
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    2485: ETV6 represses Pax5 in early B-cell development
  12. 259452
    “…METHODS/STUDY POPULATION: Mechanical loading: The NYU School of Medicine Institutional Animal Care and Use Committee approved all procedures. …”
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    2010 Use it but still lose it: Exploring age-related changes in skeletal stem cell location and activation in response to physical stimulation
  13. 259453
    “…Verify the impact of novel variants in independent samples: In silico (analyze genetic databases for suspected variants), in vivo (assess bleeding in animal models of hemophilia after introducing presumed modifier variants). 2. …”
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    3409 The Power of Phenotypic Extremes in Detecting Novel Genetic Modifiers of Hemophilia
  14. 259454
    “…METHODS/STUDY POPULATION: Wild-type Sprague-Dawley rats were inoculated with an adenoviral vector containing bioactive TGF-beta or sham at 1×10(9) pfu/animal placed in the left nares. Seven days post-inoculation, functional, and biochemical measures were conducted. …”
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    2058 miRNA manipulation to improve CFTR correction in cystic fibrosis
  15. 259455
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    Combining Fixed-Time Insemination and Improved Catheter Design in an Effort to Improve Swine Reproduction Efficiency
  16. 259456
    “…The cells were also tested in vivo in a large animal model. IVD degeneration was induced after an annular puncture in pigs, 4 weeks later the cells were injected and IVDs were analyzed at 12 weeks after the injury using MRI, gene expression analysis and histology. …”
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    Human iPSCs can be differentiated into notochordal cells that reduce intervertebral disc degeneration in a porcine model
  17. 259457
    “…Minocycline is anti-inflammatory, protects against the toxic effects of β-amyloid in vitro and in animal models of AD, and is a credible repurposed treatment candidate. …”
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    Minocycline at 2 Different Dosages vs Placebo for Patients With Mild Alzheimer Disease: A Randomized Clinical Trial
  18. 259458
    “…Cervids such as moose (Alces alces) are popular as superior sources of low-fat lean meat with balanced omega 6:3 essential fatty acids compared to traditional farm raised or domesticated meat animals due to the forage they consume as a normal part of their diet [2,4,5]. …”
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    Dataset on improved nutritional quality and safety of grilled marinated and unmarinated ruminant meat using novel unfiltered beer-based marinades
  19. 259459
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    Meat Production from Dairy Breed Lambs Due to Slaughter Age and Feeding Plan Based on Wheat Bran
  20. 259460
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    Residual feed intake divergence during the preweaning period is associated with unique hindgut microbiome and metabolome profiles in neonatal Holstein heifer calves
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