“…Currently, at least 20 animal models have been officially recognized to represent the phenotype and biochemistry of the 17 different types of OI in humans. …”
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“…SIMPLE SUMMARY: In the EU, research projects using animals must be evaluated and approved by an ethical committee prior to start to balance potential harm to the animals with potential benefit to humans, in order to ensure moral standards, scientific validity, and public trust. …”
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“…While several neuropathological alterations in tremor disorders have been observed in post-mortem studies of human brains, a full understanding of the relationship between brain circuitry alterations and tremor requires testing in animal models. Additionally, tremor animal models are critical for our understanding of tremor pathophysiology, and/or to serve as a platform for therapy development. …”
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“…Humans and animals host diverse communities of microorganisms important to their physiology and health. …”
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“…These technologies allow systemic administration of antisense, making gene knockdowns and splice modification feasible in adult animals; this review presents examples of such animal studies. …”
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“…Since actinomycosis caused by Actinomyces denticolens have been demonstrated in horses recently, it is necessary to recognize that Actinomyces denticolens is the pathogenic actinomycetes in broader range of animals.…”
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“…Here, we review the progress on animal models of ZIKV infection during pregnancy. …”
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“…Ransohoff, Entrepreneur-in-Residence at Third Rock Ventures and Visiting Scientist at Harvard Medical School, provides his personal opinion on using animal models to address current challenges and opportunities in drug development for neurodegeneration.…”
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“…There is a high demand for a veterinary education in animal welfare (AW) with different approaches from the academic, society and trade points of view. …”
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“…C. abortus can infect a variety of animals and cause foetal loss in livestock resulting in economic loss. …”
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“…METHODS: Neonatal rhesus monkeys with an average age of 15-20 d and an average weight of 500 g ± 150 g received intragastric administration of varying doses of SA11 RV ( 10(7) PFUs/mL, 10(6) PFUs/mL, or 10(5) PFUs/mL, 10 mL/animal) to determine whether the SA11 strain can effectively infect these animals by observing their clinical symptoms, fecal shedding of virus antigen by ELISA, distribution of RV antigen in the organs by immunofluorescence, variations of viral RNA load in the organs by qRT-PCR, histopathological changes in the small intestine by HE staining, and apoptosis of small intestinal epithelial cells by TUNEL assay. …”
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“…Here, we present a novel cloud-based relational database for multimodal animal data, which operates on commercial software. …”
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“…In the past few years, physiological outcomes in established animal models of hypertension, in particular in regard to sex differences, have varied from study to study or laboratory to laboratory. …”
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“…This paper explores anthropomorphism in human–animal interactions from the theoretical perspectives of pragmatism and anthropology of human–animal communication. …”
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“…Dimorphic fungi can be found in the yeast form during infection and as hyphae in the environment and are responsible for a large number of infections worldwide. Invertebrate animals have been shown to be convenient models in the study of fungal infections. …”
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“…The Faculty of Medicine, University of Colombo (UCFM), is the forerunner in the laboratory animal science (LAS) field in Sri Lanka. Here laboratory animals such as rats, frogs and rabbits were used in medical education to demonstrate physiological principles in the early 1950s. …”
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