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  1. 5061
    “…To study its pathogenesis and develop therapeutics, animal models representing its pathologies are needed. …”
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    The domestic cat as a natural animal model of Alzheimer’s disease
  2. 5062
    por Sakuma, Tetsushi
    Publicado 2015
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    Front-line of genome editing technology for animal cell engineering
  3. 5063
    “…This review will examine the strengths and weaknesses of the various animal models currently in use in preclinical studies of cartilage repair.…”
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    The benefits and limitations of animal models for translational research in cartilage repair
  4. 5064
    por Galtier, Nicolas
    Publicado 2016
    “…Our results reveal that adaptive processes dominate the evolution of proteins in most animal species, but do not corroborate the hypothesis that adaptive substitutions accumulate at a faster rate in large populations. …”
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    Adaptive Protein Evolution in Animals and the Effective Population Size Hypothesis
  5. 5065
    “…A molecular complex scaffolded by the GK protein-interaction domain (GK(PID)) mediates spindle orientation in diverse animal taxa by linking microtubule motor proteins to a marker protein on the cell cortex localized by external cues. …”
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    Evolution of an ancient protein function involved in organized multicellularity in animals
  6. 5066
    “…Tolerance of alfalfa (Medicago sativa L.) to animal grazing varies widely within the species. However, the molecular mechanisms influencing the grazing tolerant phenotype remain uncharacterized. …”
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    Transcriptome responses in alfalfa associated with tolerance to intensive animal grazing
  7. 5067
    “…Our study provides important insights on the pathophysiological processes during extracorporeal tissue perfusion and provides a validated small animal perfusion model for further studies.…”
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    Development of an Extracorporeal Perfusion Device for Small Animal Free Flaps
  8. 5068
    “…In this report, we describe a rapid 96-well microfluidic double sandwich immunoassay for the sensitive detection of BoNT-A from animal sera. This BoNT microfluidic assay requires only 5 μL of serum, provides results in 75 min using a standard fluorescence microplate reader and generates minimal hazardous waste. …”
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    Rapid Microfluidic Assay for the Detection of Botulinum Neurotoxin in Animal Sera
  9. 5069
    “…On the test day, SJ was administered 1 h prior to electric shock or chemical inducers (INH/PTZ/apomorphine) in experimental animals; the animals were then observed for different phases of seizures and psychotic behaviours. …”
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    Antiepileptic and antipsychotic activities of standardized Śilājatu (Shilajit) in experimental animals
  10. 5070
    “…BACKGROUND: Animals models have played an important role in enhancing our understanding of the pathogenesis of pulmonary arterial hypertension (PAH). …”
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    Reversal of MicroRNA Dysregulation in an Animal Model of Pulmonary Hypertension
  11. 5071
    “…The large genetic diversity present in isolates of this serotype may convey competitive advantages to this organism, while the presence of antimicrobial resistance represents a potential zoonotic risk via animal-source food products.…”
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    Phenotypic and Genotypic Characterization of Animal-Source Salmonella Heidelberg Isolates
  12. 5072
    por Oh, Ding Y., Hurt, Aeron C.
    Publicado 2016
    “…Central to this is the animal model of influenza infection, which has played an important role in understanding treatment effectiveness and the effect of antivirals on host immune responses. …”
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    Using the Ferret as an Animal Model for Investigating Influenza Antiviral Effectiveness
  13. 5073
    “…PURPOSE: To fight animal rabies, Moroccan veterinary authorities organize annual dog mass vaccination campaigns using Rabivac vaccine, an inactivated adjuvanted cell culture veterinary rabies vaccine. …”
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    Immunogenicity and efficacy of Rabivac vaccine for animal rabies control in Morocco
  14. 5074
    “…Creating this animal model of tendinopathy by long term treadmill running is however time-consuming, costly and may vary among animals. …”
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    Creating an Animal Model of Tendinopathy by Inducing Chondrogenic Differentiation with Kartogenin
  15. 5075
    “…These genes are involved in a wide variety of functions during animal development. As most Prdm genes have been studied in vertebrates, especially in mice, little is known about the evolution of this gene family. …”
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    Evolution of Prdm Genes in Animals: Insights from Comparative Genomics
  16. 5076
    “…OBJECTIVE: To evaluate the structural and molecular changes in the extracellular matrix (ECM) during the process of intervertebral disc degeneration, using animal model. METHODS: Wistar rats underwent intervertebral disc degeneration through 20-gauge needle puncture, and 360° rotation applied for 30 sec, representing the degenerated group, while control group was not submitted to this procedure. …”
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    STUDIES OF MOLECULAR CHANGES IN INTERVERTEBRAL DISC DEGENERATION IN ANIMAL MODEL
  17. 5077
    “…BACKGROUND: In plant-derived animal feedstuffs, nearly 80 % of the total phosphorus content is stored as phytate. …”
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    Development of phytase-expressing chlamydomonas reinhardtii for monogastric animal nutrition
  18. 5078
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    dbPAF: an integrative database of protein phosphorylation in animals and fungi
  19. 5079
    “…In this review, we summarize the double roles of macrophage in neuroimmune diseases and their animal models to further explore the mechanisms of macrophages involved in the pathogenesis of these disorders, which may provide a potential therapeutic approach for these disorders in the future.…”
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    Double Roles of Macrophages in Human Neuroimmune Diseases and Their Animal Models
  20. 5080
    “…The aim of this study was to evaluate the role of an alternative therapy i.e. application of S. aureus specific bacteriophages in cases of osteomyelitis caused by MRSA in animal model. METHODS: Twenty two rabbits were included in this study. …”
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    Phage therapy of staphylococcal chronic osteomyelitis in experimental animal model
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