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6181“…By using a two stage model of carcinogenesis, we generated Monte Carlo studies to assess the efficiency and robustness of the 3-poly test for animal carcinogenicity experiments. The Monte Carlo results indicate that the 3-poly test is quite powerful for detecting the carcinogenic effects of complete carcinogens, moderate promoters, and initiators with moderate or large effect, but, in some cases, it is less powerful for weak initiators or weak promoters. …”
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6182
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6183
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6184
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6185
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6186
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6187por Hunt, C D“…This review summarizes evidence that supports working hypotheses for the roles of boron in animal model systems. It is well established that vascular plants, diatoms, and some species of marine algal flagellates have acquired an absolute requirement for boron, although the primary role of boron in plants remains unknown. …”
Publicado 1994
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6188
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6189“…The exposure to aflatoxin B1 (AFB) in animal-feed processing plants was assessed using binding of AFB to serum albumin. …”
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6190“…The use of this procedure in laboratory animals by psychologists and neuroscientists over the past 30 years has produced a powerful animal model for studying the behavioral and biological mechanisms of learning. …”
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6191“…In these two groups a small number of animals has been investigated and the fiber characteristics were sometimes irrelevant. …”
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6192por Harkema, J R“…These species-related differences in response may be due to variations in structural, physiologic, and biochemical factors, such as gross nasal cavity structure, distribution of luminal epithelial cell populations along the nasal airway, intranasal airflow patterns, nasal mucociliary apparatus, and nasal xenobiotic metabolism among animal species. This paper reviews the comparative anatomy and irritant-induced pathology of the nasal cavity in laboratory animals. …”
Publicado 1990
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6193por Kern, E R“…Viral infections in animal models appear to be ideal systems for determining toxicity to the immune system by environmental substances. …”
Publicado 1982
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6194por Stebbins, W C“…It is necessary but not sufficient to develop laboratory animal models in sensory behavioral toxicology for screening toxic substances and for the analysis of sensory impairment at threshold levels of stimulation. …”
Publicado 1982
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6195por Ogao, Patrick J“…Also, exploring geospatial data structures using animation is best achieved using provocative interactive tools such as was seen with the inference-based animation. …”
Publicado 2006
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6196por Saffiotti, Umberto“…Experimental methods for the identification of chemical carcinogens have been extensively developed, including animal bioassay methods, animal models for cancer induction at major organ sites, models for the study of the effects of carcinogens in cells and tissues in culture and methods for the study of molecular events (metabolic activation, binding and detoxification of carcinogens; DNA damage and repair; mutagenicity). …”
Publicado 1978
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6197“…Soil management programs have been developed to maintain animal dietary levels of Cd at less than 1.0 μg/g from the use of sewage sludge on land in Pennsylvania. …”
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6198“…We update our 1997 publication by reviewing 29 new reports of tests of magnetic fields (MFs) in six different in vivo animal models of carcinogenesis: 2-year, lifetime, or multigeneration exposure studies in rats or mice; and promotion/progression models (rat mammary carcinoma, rat liver focus, mouse skin, several models of human leukemia/lymphoma in rats and mice, and brain cancer in rats). …”
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6199“…Human epidemiological and animal studies have revealed the long-term effects of malnutrition during gestation and early life on the health of the offspring. …”
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6200“…Although there are differences between the human reproductive system and that of the usual animal models, such models have been extremely useful in assessing risks for key human reproductive and developmental processes. …”
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