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8621por Sullivan, Courtney R., Mielnik, Catharine A., Funk, Adam, O’Donovan, Sinead M., Bentea, Eduard, Pletnikov, Mikhail, Ramsey, Amy J., Wen, Zhexing, Rowland, Laura M., McCullumsmith, Robert E.“…We examined the concentration of lactate in postmortem brain (dorsolateral prefrontal cortex) in subjects with schizophrenia, in two animal models of schizophrenia, the GluN1 knockdown mouse model and mutant disrupted in schizophrenia 1 (DISC1) mouse model, as well as inducible pluripotent stem cells (iPSCs) from a schizophrenia subject with the DISC1 mutation. …”
Publicado 2019
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8622“…PURPOSE: The purpose of this study was to investigate how intravenously injected bone marrow-derived mesenchymal stem cells (BMSCs) are distributed in the body of an Alzheimer’s disease (AD) animal model. METHODS: Stem cells were collected from bone marrow of mice and labeled with Indium-111 ((111)In). …”
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8623por Barboni, B., Russo, V., Berardinelli, P., Mauro, A., Valbonetti, L., Sanyal, H., Canciello, A., Greco, L., Muttini, A., Gatta, V., Stuppia, L., Mattioli, M.“…In this context, placenta-derived stem cells isolated from domestic animals have covered a dual role, acting both as therapies for patients and as a valuable cell source for translational models. …”
Publicado 2018
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8624por Colombo, Ana Caroline, Rella, Antonella, Normile, Tyler, Joffe, Luna S., Tavares, Patricia M., de S. Araújo, Glauber R., Frases, Susana, Orner, Erika P., Farnoud, Amir M., Fries, Bettina C., Sheridan, Brian, Nimrichter, Leonardo, Rodrigues, Marcio L., Del Poeta, MaurizioEnlace del recurso
Publicado 2019
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8625por Zhang, Li, Shen, Zhi-Li, Feng, Yue, Li, Dao-Qun, Zhang, Na-Na, Deng, Yong-Qiang, Qi, Xiao-Peng, Sun, Xiao-Mei, Dai, Jie-Jie, Yang, Chun-Guang, Yang, Zi-Feng, Qin, Cheng-Feng, Xia, Xue-Shan“…Recently, we have proved a novel small animal tree shrew was susceptive to ZIKV infection and presented the most common rash symptoms as ZIKV patients. …”
Publicado 2019
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8626
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8627por Abell, J. T., Quade, J., Duru, G., Mentzer, S. M., Stiner, M. C., Uzdurum, M., Özbaşaran, M.“…Dung and midden layers at Aşıklı Höyük are highly enriched in soluble sodium, chlorine, nitrate, and nitrate-nitrogen isotope values, a pattern we attribute largely to urination by humans and animals onto the site. Here, we present an innovative mass balance approach to interpreting these unusual geochemical patterns that allows us to quantify the increase in caprine management over a ~1000-year period, an approach that should be applicable to other arid land tells.…”
Publicado 2019
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8628por Jin, Yining, Acharya, Harini G., Acharya, Devansh, Jorgensen, Rick, Gao, Haoran, Secord, James, Ng, Perry K. W., Gangur, Venugopal“…A comprehensive review on the molecular mechanisms of wheat allergenicity using animal models is unavailable at present. There were two major objectives of this study: To identify the lessons that animal models have taught us regarding the molecular mechanisms of wheat allergenicity and to identify the strengths, challenges, and future prospects of animal models in basic and applied wheat allergy research. …”
Publicado 2019
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8629por Sottorff, Ignacio, Künzel, Sven, Wiese, Jutta, Lipfert, Matthias, Preußke, Nils, Sönnichsen, Frank D., Imhoff, Johannes F.“…By a cultivation-based approach, the responsibility of symbionts of a marine invertebrate for the production of complex natural products found within the animal’s extracts could be demonstrated. This finding re-opens the debate about the producers of secondary metabolites in sea animals. …”
Publicado 2019
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8630por Cottrill, Ethan, Ahmed, A Karim, Lessing, Noah, Pennington, Zachary, Ishida, Wataru, Perdomo-Pantoja, Alexander, Lo, Sheng-fu, Howell, Elizabeth, Holmes, Christina, Goodwin, C Rory, Theodore, Nicholas, Sciubba, Daniel M, Witham, Timothy F“…Extracted data for each model included surgical approach, level of fusion, animal species and breed, animal age and sex, and any other relevant characteristics. …”
Publicado 2019
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8631por Waterton, John C., Hines, Catherine D.G., Hockings, Paul D., Laitinen, Iina, Ziemian, Sabina, Campbell, Simon, Gottschalk, Michael, Green, Claudia, Haase, Michael, Hassemer, Katja, Juretschke, Hans-Paul, Koehler, Sascha, Lloyd, William, Luo, Yanping, Mahmutovic Persson, Irma, O'Connor, James P.B., Olsson, Lars E., Pindoria, Kashmira, Schneider, Jurgen E., Sourbron, Steven, Steinmann, Denise, Strobel, Klaus, Tadimalla, Sirisha, Teh, Irvin, Veltien, Andor, Zhang, Xiaomeng, Schütz, Gunnar“…BACKGROUND: Many translational MR biomarkers derive from measurements of the water proton longitudinal relaxation rate R(1), but evidence for between-site reproducibility of R(1) in small-animal MRI is lacking. OBJECTIVE: To assess R(1) repeatability and multi-site reproducibility in phantoms for preclinical MRI. …”
Publicado 2019
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8632por Hikufe, Emmanuel H., Freuling, Conrad M., Athingo, Rauna, Shilongo, Albertina, Ndevaetela, Emmy-Else, Helao, Maria, Shiindi, Mathews, Hassel, Rainer, Bishi, Alec, Khaiseb, Siegfried, Kabajani, Juliet, van der Westhuizen, Jolandie, Torres, Gregorio, Britton, Andrea, Letshwenyo, Moetapele, Schwabenbauer, Karin, Mettenleiter, Thomas C., Denzin, Nicolai, Amler, Susanne, Conraths, Franz J., Müller, Thomas, Maseke, Adrianatus“…The study presented assesses the baseline data for both human and animal rabies surveillance in Namibia in recent times and establishes correlations with ecological and socio-economic data in order to provide an up-to-date picture on the epidemiology of rabies in Namibia. …”
Publicado 2019
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8633“…Animal models of diseases are invaluable tools of modern medicine. …”
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8634
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8635por Fehlmann, Tobias, Backes, Christina, Pirritano, Marcello, Laufer, Thomas, Galata, Valentina, Kern, Fabian, Kahraman, Mustafa, Gasparoni, Gilles, Ludwig, Nicole, Lenhof, Hans-Peter, Gregersen, Henrike A, Francke, Richard, Meese, Eckart, Simon, Martin, Keller, Andreas“…The repertoire of small noncoding RNAs (sncRNAs), particularly miRNAs, in animals is considered to be evolutionarily conserved. …”
Publicado 2019
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8636“…The reviewed studies exemplify the key roles played by microRNAs in the regulation and evolution of gene expression during developmental processes in animals.…”
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8637“…SIMPLE SUMMARY: A previous study into successful international animal welfare management strategy presented the vital need for animal welfare proponents to establish mutual benefits with the livestock industry. …”
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8638“…The aim of this systematic review was to compile the current knowledge about this animal model as well as to address gaps in knowledge. …”
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8639
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8640“…We will then introduce a novel tool, base editors (BEs), which present a new promising approach to establish pathogenically relevant animal models. Finally, we will discuss the application of BEs in non-human primates and share our perspectives on future development of base-editing techniques.…”
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