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259841por Keay, Sheila, Poljak, Zvonimir, Alberts, Famke, O’Connor, Annette, Friendship, Robert, O’Sullivan, Terri L., Sargeant, Jan M.Enlace del recurso
Publicado 2023
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259842por Zhu, Fengcai, Huang, Shoujie, Liu, Xiaohui, Chen, Qi, Zhuang, Chunlan, Zhao, Hui, Han, Jinle, Jaen, Anjuli May, Do, Thai Hung, Peter, Jonathan Grant, Dorado, Alexander Gonzalez, Tirador, Louie S, Zabat, Gelza Mae A, Villalobos, Ralph Elvi M, Gueco, Gemalyn Pineda, Botha, Lauren Livia Greta, Iglesias Pertuz, Shirley Patricia, Tan, Jiaxiang, Zhu, Kongxin, Quan, Jiali, Lin, Hongyan, Huang, Yue, Jia, Jizong, Chu, Xiafei, Chen, Junyu, Chen, Yixin, Zhang, Tianying, Su, Yingying, Li, Changgui, Ye, Xiangzhong, Wu, Ting, Zhang, Jun, Xia, Ningshao“…BACKGROUND: The live-attenuated influenza virus vector-based intranasal SARS-CoV-2 vaccine (dNS1-RBD, Pneucolin; Beijing Wantai Biological Pharmacy Enterprise, Beijing, China) confers long-lasting and broad protection in animal models and is, to our knowledge, the first COVID-19 mucosal vaccine to enter into human trials, but its efficacy is still unknown. …”
Publicado 2023
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259843por Quan, Chuntao, Wu, Zhijie, Xiong, Juan, Li, Manqing, Fu, Yu, Su, Jiaying, Wang, Yue, Ning, Lvwen, Zhang, Deju, Xie, Ni“…RESULTS: Here, we reported that PARP1 was amplified in breast cancer cells and CDK4/6i-resistant patients, and knockdown or inhibition of PARP1 reversed drug resistance in cell experiments and animal models. In addition, upregulation of transcription factor YB-1 also occurred in CDK4/6i-resistant breast cancer, and YB-1 inhibition can regulate PARP1 expression. p-YB-1 and PARP1 were upregulated when treated with CDK4/6i based on the WB and IF results, and elevated PARP1 and p-YB-1 were almost simultaneously observed during the construction of MCF7AR-resistant strains. …”
Publicado 2023
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259844“…CONCLUSION: Prominent fibrin deposition in two different animal models of RA – AIA and CIA – can be attributed to modulations in key regulatory genes for coagulation and fibrinolysis.…”
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259845ACTIVE IMMUNITY PRODUCED BY SO CALLED BALANCED OR NEUTRAL MIXTURES OF DIPHTHERIA TOXIN AND ANTITOXINpor Smith, Theobald“…Madsen has, however, approached it very closely in his experiments on the immunization of animals with mixtures not fully balanced, or, in other words, in which the "toxones" were still free. …”
Publicado 1909
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259846por Marine, David“…There is no evidence that removal of the animals from their native environment to the laboratory either increases or decreases the rate of metamorphosis. …”
Publicado 1913
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259847“…The result of this study proves that some species of amœbæ from liver abscesses and the human intestine can be cultivated upon various autolyzed tissues of man and some of the lower animals without a symbiotic microorganism. Their cultivation from liver abscesses upon such bacteria-free autolyzed tissue indicates that their multiplication in these lesions depends upon some product or products in the process of dissociation of the liver cells. …”
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259848por Blake, Francis G.“…Although it is fully realized that Koch's postulates have not been fulfilled in the absence of successful animal experimentation, nevertheless the accumulated evidence here presented leaves little reason to doubt that the specific cause of rat-bite fever is Streptothrix muris ratti. …”
Publicado 1916
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259849“…The rates of disappearance were irregular in different animals and bore no direct relation to the initial titers. …”
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259850“…In comparison, similar material from cases of epidemic influenza do, however, cause particular changes in the blood and lungs of these animals, cultures of the lungs often yielding Bacterium pneumosintes. …”
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259851por Lurie, Max B.“…They suggest that the prompt rise of antibodies in reinfected animals may play a rôle in the immunity to tuberculosis. …”
Publicado 1929
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259852por Oliver, Jean“…All these contrasts between the simplicity of our experiments and the complexity that must obtain when the problem is investigated in the living animal, particularly if mammals are used whose renal activity is only partially understood, add considerable weight to the conclusion that functional examination is unable to differentiate between two types of damage of very different significance, the one vascular, transient and reversible, the other parenchymal, permanent and, as far as the cells involved are concerned, irreparable. …”
Publicado 1932
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259853por Dot, C., Parier, V., Behar-Cohen, F., BenEzra, D., Jonet, L., Goldenberg, B., Picard, E., Camelo, S., de Kozak, Y., May, F., Soubrane, G., Jeanny, J. C.“…To determine, by RT–PCR, the time course of glial fibrillary acidic protein (GFAP), vascular endothelial growth factor (VEGF), and monocyte chemotactic protein-1 (MCP-1) gene expression, we delivered ten laser burns (50 µm, 400 mW, 0.05 s) to each retina in 10–12-week-old mice (group III’, n=10) and 1-year-old mice (group IV’, n=10). Animals from Groups III’ and IV’ had the same age than those from Groups III and IV, but they received ten laser impacts in each eye and served for the molecular analysis. …”
Publicado 2009
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259854por Denkert, Carsten, Huober, Jens, Loibl, Sibylle, Prinzler, Judith, Kronenwett, Ralf, Darb-Esfahani, Silvia, Brase, Jan C, Solbach, Christine, Mehta, Keyur, Fasching, Peter A, Sinn, Bruno V, Engels, Knut, Reinisch, Mattea, Hansmann, Martin-Leo, Tesch, Hans, von Minckwitz, Gunter, Untch, Michael“…Crosstalk between the estrogen receptor (ER) and the HER2 pathway has been suggested based on cell culture and animal models [14]. Consequently, the 2011 St Gallen panel has pointed out that HER2-positive tumors should be divided into two groups based on expression of the ER [15]. …”
Publicado 2013
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259855por Runge, Claire A, Tulloch, Ayesha, Hammill, Edd, Possingham, Hugh P, Fuller, Richard A“…Climate change is predicted to affect the pattern of resource fluctuations across much of the southern hemisphere, where nomadism is the dominant form of animal movement, so it is critical we begin to understand the consequences of this for accurate threat assessment of nomadic species. …”
Publicado 2015
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259856por Kalasariya, R. M., Dhami, A. J., Hadiya, K. K., Borkhatariya, D. N., Patel, J. A.“…Further, 15 buffaloes, each of control and treatment group, were injected parentrally (deep i/m) with 5 ml of micro-minerals (each ml containing Se, Zn, Cu and Mn at 5, 40, 15 and 10 mg, respectively), twice 2 months before and on the day of calving, keeping rest of the animals (control, n=30 and treatment, n=25) as controls. …”
Publicado 2017
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259857por Maidarti, Mila, Clarkson, Yvonne L, McLaughlin, Marie, Anderson, Richard A, Telfer, Evelyn E“…WIDER IMPLICATIONS OF THE FINDINGS: In vitro activation of follicle growth may compromise the bidirectional signalling between oocyte and granulosa cells necessary for optimal oocyte and follicle health. This large animal model may be useful in optimising follicle activation protocols with a view to transfer for clinical application. …”
Publicado 2019
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259858por Ntemou, E, Kadam, P, Van Saen, D, Wistuba, J, Mitchell, R T, Schlatt, S, Goossens, E“…STUDY DESIGN, SIZE, DURATION: In this study, we used marmoset as a pre-clinical animal model. ITT was obtained from two 6-month-old co-twin marmosets. …”
Publicado 2019
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259859“…Background: Exercise therapy has been widely applied in clinical rehabilitation as an important practical and side effect—free adjuvant therapy, with a significant effect in alleviating motor dysfunction of patients with Parkinson’s disease (PD) or animal PD models. This study focuses on the effect of exercise therapy in reducing the concentration of extracellular glutamate (Glu) in the striatum in a rat PD model by upregulating the expression of group II metabotropic Glu receptor (mGluR2/3), so as to alleviate motor dysfunction in the rat PD model. …”
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259860“…One tailed ANOVA followed by Dunnett’s post-hoc test was used to establish significance. All animal experiments were conducted as described in approved IACUC protocols. …”
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