“…LDV might be a primary example for the effectiveness of a permanent clonal CTL deletion in adult animals under natural conditions of infection. The presumed modes of transmission of LDV in nature and the events associated with its infection of mice are strikingly similar to those observed during the acute and asymptomatic phases of infection with human immunodeficiency virus (HIV) [24, 29, 74, 78]. …”
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“…WHAT IS KNOWN ALREADY: Animal studies indicate that the embryo culture environment affects the DNA methylation status of the embryo. …”
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“…A total of 567 cows at the time of calving were enrolled, but for the final analyses only 521 animals were considered. The cows were randomly assigned on a daily basis into 1 of 3 groups: (1) control group (n = 177), (2) application of 20 IU of oxytocin i.m. …”
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“…Methods: The in vitro investigation of the novel compounds alongside with the reference peptides PentixaFor and PentixaTher encompassed the determination of hCXCR4 and mCXCR4 affinity (IC(50)) of the respective (nat)Ga-, (nat)Lu-, (nat)Y- and (nat)Bi-complexes in Jurkat and Eμ-myc 1080 cells using [(125)I]FC-131 and [(125)I]CPCR4.3 as radioligands, respectively, as well as the evaluation of the internalization and externalization kinetics of selected (68)Ga- and (177)Lu-labeled compounds in hCXCR4-transfected Chem-1 cells. Comparative small animal PET imaging studies (1h p.i.) as well as in vivo biodistribution studies (1, 6 and 48h p.i.) were performed in Daudi (human B cell lymphoma) xenograft bearing CB17 SCID mice. …”
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“…La négativité des sérologies pourrait s’expliquer par une déplétion lymphocytaire B transitoire induite par l’INF-1, ainsi que décrite chez l’animal en réponse à une infection au virus de la chorioméningite lymphocytaire. …”
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“…Such morphometric, behavioral, growth-related, and reproductive advantages shown by the HSR-goats gave evidence to emphasize the need to better comprehend the biological foundation of relevant animal traits, and to be able to define future balanced management and breeding programs. …”
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“…Moreover, the efficacy and side effects of L-dopa treatment are extremely heterogeneous across Parkinson’s patients, and this variability cannot be completely explained by differences in host metabolism RATIONALE: Previous studies in humans and animal models have demonstrated that the gut microbiota can metabolize L-dopa. …”
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“…Trainee research was also severely impacted as laboratories closed, experimental animal colonies were lost, and many research activities ceased. …”
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“…Ironically, it has the potential of increasing the risk of recurrent anterior uveitis because of its ability to attach to TNF-beta, which is important for uveal health as proven in animal models. Therefore, in this case the diagnostic accuracy is imperative as the choice of treatment could cause adverse effects if it was wrong.…”
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“…BACKGROUND: Therapeutic modulation of TREM2-dependent microglial function might provide an additional strategy to slow the progression of Alzheimer's disease. Although studies in animal models suggest that TREM2 is protective against Alzheimer's pathology, its effect on tau pathology and its potential beneficial role in people with Alzheimer's disease is still unclear. …”
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“…After 7–8 weeks, mice were sacrificed, and tumors were excised and weighed. Studies on animals were conducted with approval from the Animal Research Ethics Committee of the University of Rochester Medical Center. …”
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“…Part IBiomaterials ScienceBiomaterials Science and EngineeringLearning ObjectivesMaterials Science and EngineeringMultilevels of Structure and Categorization of MaterialsFour Categories of MaterialsDefinitions of Biomaterials, Biomedical Materials, and Biological MaterialsBiocompatibilityChapter HighlightsActivitiesSimple Questions in ClassProblems and ExercisesBibliographyToxicity and CorrosionLearning ObjectivesElements in the BodyBiological Roles and Toxicities of Trace ElementsSelection of Metallic Elements in Medical-Grade AlloysCorrosion of MetalsEnvironment inside the BodyMinimization of Toxicity of Metal ImplantsChapter HighlightsLaboratory Practice 1Simple Questions in ClassProblems and ExercisesAdvanced Topic: Biological Roles of Alloying ElementsBibliographyMechanical Properties of BiomaterialsLearning ObjectivesRole of Implant BiomaterialsMechanical Properties of General ImportanceHardnessElasticity: Resilience and StrechabilityMechanical Properties Terms Used in the Medical CommunityFailureEssential Mechanical Properties of Orthopedic Implant BiomaterialsChapter HighlightsActivitiesSimple Questions in ClassProblems and ExercisesBibliographyMetallic Biomaterials in Orthopedic ImplantsLearning ObjectivesDevelopment of Metallic BiomaterialsStainless SteelsCobalt-Based AlloysTitanium AlloysComparison of Stainless Steels, Cobalt, and Titanium AlloysSummary and RemarksChapter HighlightsActivitiesSimple Questions in ClassProblems and ExercisesBibliographyMetallic Biomaterials: Miscellaneous OthersLearning ObjectivesDental MaterialsNiTi Shape-Memory AlloysOther Clinically Applied Metallic MaterialsNew Metallic Materials: Magnesium AlloysChapter HighlightsLaboratory Practice 2Simple Questions in ClassProblems and ExercisesBibliographyBioinert CeramicsLearning ObjectivesOverview of BioceramicsInert Bioceramics: Al2O3Inert Bioceramics: ZrO2Two Types of JointsSummary and Remarks on Al2O3 and ZrO2Dental CeramicsChapter HighlightsActivitiesSimple Questions in ClassProblems and ExercisesAdvanced Topic: Total Joint ReplacementBibliographyBioactive and Bioresorbable CeramicsLearning ObjectivesOverview of Surface Bioactive and Bulk Degradable CeramicsCalcium Phosphates and HydroxyapatiteBioactive GlassesBioactive Glass-CeramicsBone-Bonding MechanismsBiodegradable CeramicsChapter HighlightsLaboratory Practice 3Simple Questions in ClassProblems and ExercisesAdvanced Topic: Bioceramic Scaffolds for Bone Tissue EngineeringBibliographyPolymeric Biomaterials: FundamentalsLearning ObjectivesBasic Concepts on PolymersOverview of Polymeric BiomaterialsChapter HighlightsActivitiesSimple Questions in ClassProblems and ExercisesAdvanced Topic: Polymers and Polymer Scaffolds for Soft Tissue EngineeringBibliographyBioinert PolymersLearning ObjectivesPolyolefinPoly(Ethylene Terephthalate)Acrylate PolymerFluorocarbon PolymersSiliconePolyurethaneChapter HighlightsActivitiesSimple Questions in ClassProblems and ExercisesAdvanced Topic: Properties and Applications of Polyurethane as BiomaterialsBibliographyBioresorbable PolymersLearning ObjectivesBiodegradation of PolymersPolyesters: PGA, PLA, and PCLPolyesters: PHAElastomeric Polyester: Poly(Polyol Sebacate)Polyether: Poly(Ethylene Glycol)PolyamideSurface-Erodible PolymersBiological PolymersChapter HighlightsSimple Questions in ClassProblems and ExercisesLaboratory Practice 4Advanced Topic: Natural Polymers: Resilin, Silk, and GlutenBibliographyComposite BiomaterialsLearning ObjectivesOverview of CompositesNatural Composites: BoneDental CompositesArtificial BoneChapter HighlightsLaboratory Practice 5Simple Questions in ClassProblems and ExercisesAdvanced Topic: Development of Artificial Bone: Composites and ScaffoldsBibliographyPart IIMedical ScienceMedicine and Medical ScienceLearning ObjectivesMedicine and Medical ScienceMedical Science versus Materials ScienceLearning Goals of Part IIChapter HighlightsActivityBibliographyImage LinksSimple Questions in ClassProblems and ExercisesHuman Anatomy And Diseases I: Integumentary, Skeletal, Muscular, Nervous, and Endocrine SystemsLearning ObjectivesIntegumentary SystemSkeletal SystemMuscular SystemNervous SystemEndocrine SystemChapter HighlightsActivitiesSimple Questions in ClassProblems and ExercisesAdvanced Topic: Biomaterial Challenges in Bone Tissue EngineeringBibliographyHuman Anatomy And Diseases II: Cardiovascular SystemLearning ObjectivesAnatomy and Functions of the Cardiovascular SystemCardiovascular DiseaseCardiac Performance: P-V LoopCurrent Therapies for Heart DiseaseAlternative Treatments and Application of BiomaterialsArtificial Blood VesselsChapter HighlightsActivitiesSimple Questions in ClassProblems and ExercisesBibliographyHuman Anatomy And Diseases III: Respiratory, Lymphatic, Digestive, Urinary, and Reproductive SystemsLearning ObjectivesRespiratory SystemLymphatic SystemDigestive SystemUrinary SystemReproductive SystemChapter HighlightsActivitiesSimple Questions in ClassProblems and ExercisesBibliographyCells and BiomoleculesLearning ObjectivesIntroductionCell Biochemistry and BiosynthesisCell StructureTransport across Plasma MembranesCell ProliferationCell Differentiation and Stem CellsChapter HighlightsActivitiesAdvanced Topic: Cell Therapy to Treat Cardiac DiseaseStrategies to Address Immune Rejection in CellsSummary of Cell-Based Therapies and Their LimitationsSimple Questions in ClassProblems and ExercisesBibliographyHistology and Tissue Properties I: Epithelial, Neuronal, and Muscle TissueLearning ObjectivesIntroductionEpitheliumMuscular TissueNervous TissueChapter HighlightsActivitiesAdvanced Topic: Properties of Proteins in Mammalian TissuesSimple Questions in ClassProblems and ExercisesBibliographyHistology and Tissue Properties II: Connective TissuesLearning ObjectivesOverview of Connective TissuesTypes of Connective TissueConnective Tissue Proper (Skin, Tendon, Ligament)Mechanical Properties of Structural ProteinsCartilageBoneChapter HighlightsLaboratory Practice 6Simple Questions in ClassProblems and ExercisesBibliographyImmune System and Body Responses to BiomaterialsLearning ObjectivesImmune SystemTissue Response to InjuriesBody Response to ImplantsChapter HighlightsActivitiesSimple Questions in ClassProblems and ExercisesBibliographyEvaluation of BiomaterialsLearning ObjectivesOverview of Biomaterials EvaluationStandardsToxicological EvaluationCytotoxicity TestingEvaluation in AnimalsChapter HighlightsLaboratory Practice 7Case Study: Evaluation of Heart Patch in RatsSimple Questions in ClassProblems and ExercisesBibliographyRegulation of Medical DevicesLearning ObjectivesRegulations versus StandardsMedical DevicesPreclinical TestingClinical TrialsDevelopment of Medical Devices and Possible Career OpportunitiesChapter HighlightsActivitiesSimple Questions in ClassProblems and ExercisesBibliographyIndex.…”
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“…In addition, HE staining and oil red O staining showed obvious AS plaque formation in the vessel wall, and a large amount of fat deposition in VSMC, thus indicating that the hyperhomocysteinemia As an animal model was successfully established. Furthermore, CTRP9 were downregulated, while GRP78, p-PERK, ATF6a, p-IRE1α, SREBP1c, SREBP2 was upregulated in aortic VSMC in the ApoE(−/−) + HMD group. …”
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“…This is in accord with findings in both human RA and animal models of RA that show that inflammation and tissue destruction sometimes are uncoupled processes. …”
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“…Regardless of elaborate serological studies and animal experiments, streptococci must be recovered consistently by several groups of laboratory workers before their etiologic rôle in chronic arthritis and rheumatic fever can be accepted. …”
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