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861por Martin, Olivia, Song, Yang, Daugherty, Sean, Sztein, Rezwan Wahidrcelo B., Fraser, Claire M.“…OBJECTIVES/GOALS: Utilize a systems biology approach to identify gene expression changes after administration of Zaire Ebola virus glycoprotein expressed in a Chimp Adeno3 vector (ChAd3-EBOZ) and either boosted ˜7 weeks later with modified vaccinia Ankara MVA expressing Zaire and Marburg GPs plus Tai forest NP (MVA-BN ®Filo) or given saline (placebo). …”
Publicado 2021
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862por McCann, Katy, von Witzleben, Adrian, Thomas, Jaya, Wang, Chuan, Wood, Oliver, Singh, Divya, Boukas, Konstantinos, Bendjama, Kaidre, Silvestre, Nathalie, Nielsen, Finn Cilius, Thomas, Gareth, Sanchez-Elsner, Tilman, Greenbaum, Jason, Schoenberger, Stephen, Peters, Bjoern, Vijayanand, Pandurangan, Savelyeva, Natalia, Ottensmeier, Christian“…In parallel, identified gene variants were incorporated into a Modified Vaccinia Ankara-based vaccine, which was evaluated in the human leucocyte antigen A*0201 transgenic mouse model (HHD). …”
Publicado 2022
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863por Ozalp Akin, Ezgi, Akbas, Aysen, Atasoy, Sidika Canan, Kanatli, Merve Cicek, Ince Acici, Selin, Mustafayev, Revan, Karaaslan, Bedriye Tugba, Ertem, Hilmi Deniz, Bingoler Pekcici, Bahar, Ertem, Ilgi“…METHODS: Using a mixed-methods longitudinal design, we recruited children with developmental difficulties aged 0–42 months with an appointment during the first lockdown at Ankara University Developmental Pediatrics Division and seen face-to-face only once before. …”
Publicado 2022
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864por Cimen, Sanem Guler, Eraslan, Asir, Uysal, Fahrettin Samil, Dogan, Ahmet Emin, Kokurcan, Alihan, Yilmaz, Muhammet Sahin, Baylan, Burhan, Cimen, Sertac“…RESULTS: This cross-sectional study was carried out between July 1, 2021, to October 31, 2021, at the Department of Medicine, Health Sciences University Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey, with participants from nine surgical specialties: General surgery, neurosurgery, orthopedics, urology, plastic surgery, ear-nose-throat surgery, cardiovascular surgery, ophthalmology, and anesthesiology. …”
Publicado 2022
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865“…The research was conducted in April 2021 with 637 married Syrian refugee women aged 15-49 living in Ankara (mean age: 29.6). The median age at first marriage was 17, and consanguinity with her spouse was 29.8%. 8.6% were illiterate. 36.3% did not/could not benefit from public hospitals free of charge, and 89.8% did not have health insurance. 96.7% had a previous pregnancy (median:4). …”
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866por Priyamvada, Lalita, Carson, William C., Ortega, Eddy, Navarra, Terese, Tran, Stephanie, Smith, Todd G., Pukuta, Elisabeth, Muyamuna, Elisabeth, Kabamba, Joelle, Nguete, Beatrice U., Likafi, Toutou, Kokola, Gaston, Lushima, Robert Shongo, Tamfum, Jean-Jacques Muyembe, Okitolonda, Emile W., Kaba, Didine K., Monroe, Benjamin P., McCollum, Andrea M., Petersen, Brett W., Satheshkumar, Panayampalli S., Townsend, Michael B.“…JYNNEOS, a Modified Vaccinia Ankara (MVA)-based live, non-replicating vaccine, was recently approved for monkeypox prevention for adults at high risk of MPXV infection in the United States. …”
Publicado 2022
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867por Atalay, Aysegul, Besimoglu, Berhan, Sinaci, Selcan, Kaya, Ecem, Ozkavak, Onur, Ocal, Fatma Doga, Ozgu-Erdinc, Ayse Seval, Sahin, Dilek“…METHODS: Consecutive pregnant women tested for SARS-CoV-2 by RT-PCR at Ankara City Hospital were recruited between January 2021 and September 2021. …”
Publicado 2022
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868por Turner Overton, Edgar, Schmidt, Darja, Vidojkovic, Sanja, Menius, Erika, Nopora, Katrin, Maclennan, Jane, Weidenthaler, Heinz“…The approved liquid-frozen formulation of Bavarian Nordic's Modified Vaccinia Ankara (MVA-BN) smallpox vaccine has specific cold-chain requirements, while the freeze-dried (FD) formulation of this vaccine provides more flexibility in terms of storage conditions and shelf life. …”
Publicado 2023
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869por Erdem, Deniz, Kayaaslan, Bircan, Cakir, Esra Yakisik, Dinc, Bedia, Asilturk, Dilek, Kirca, Fisun, Segmen, Fatih, Turan, Isil Ozkocak, Guner, Rahmet“…MATERIAL AND METHODS: Adult women with confirmed severe COVID-19 who were admitted to Ankara City Hospital intensive care unit (ICU) between December 1st, 2020, and January 1st, 2021, were enrolled in the study. …”
Publicado 2023
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870por Donnison, Timothy, McGregor, Joey, Chinnakannan, Senthil, Hutchings, Claire, Center, Rob J., Poumbourios, Pantelis, Klenerman, Paul, Drummer, Heidi E., Barnes, Eleanor“…We developed bivalent viral vector vaccines (ChAdOx1 and modified vaccinia Ankara [MVA]) encoding both Gt1‐6 and E2Δ123 immunogens (Gt1‐6‐E2Δ123) generating polyfunctional CD4(+) and CD8(+) T cells and nAb titers in prime/boost strategies. …”
Publicado 2022
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871por Pehlivanli, Aysel, Eyupoglu, Sahin, Basgut, Bilgen, Erturk, Sehsuvar, Ozcelikay, A. Tanju“…METHODS: This was a prospective interventional study conducted between October 1, 2019, and March 18, 2020, in the nephrology ward of Ankara University School of the Medicine, Ibn-i Sina Hospital. …”
Publicado 2023
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872por Perdiguero, Beatriz, Marcos-Villar, Laura, López-Bravo, María, Sánchez-Cordón, Pedro J., Zamora, Carmen, Valverde, José Ramón, Sorzano, Carlos Óscar S., Sin, Laura, Álvarez, Enrique, Ramos, Manuel, Del Val, Margarita, Esteban, Mariano, Gómez, Carmen Elena“…Here we describe the characterization, immunogenicity and efficacy of CoV2-BMEP using two delivery platforms: nucleic acid DNA and attenuated modified vaccinia virus Ankara (MVA). RESULTS: In cultured cells, both vectors produced a main protein of about 37 kDa as well as heterogeneous proteins with size ranging between 25-37 kDa. …”
Publicado 2023
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873“…METHODS: We conducted a retrospective study of data from a consecutive series of 232 neonatal patients admitted to Yildirim Beyazit University Yenimahalle Training and Research Hospital in Ankara for 2 years from 2016 to 2018. We included patients with a diagnosis of or clinically suspected infection, and healthy neonates were included as controls. …”
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874por KONAK, Hatice Ecem, ERDEN, Abdulsamet, ARMAĞAN, Berkan, GÜVEN, Serdar Can, APAYDIN, Hakan, DAĞLI, Pınar Akyüz, UZUN, Yağnur, KAYGISIZ, Merve, KÜÇÜKŞAHİN, Orhan, OMMA, Ahmet“…MATERIALS AND METHODS: This study was designed as a cross-sectional study in Ankara City Hospital rheumatology clinic between December 2021 and March 2022. …”
Publicado 2023
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875por Chiuppesi, Flavia, Ortega-Francisco, Sandra, Gutierrez, Miguel-Angel, Li, Jing, Ly, Minh, Faircloth, Katelyn, Mack-Onyeike, Jada, La Rosa, Corinna, Thomas, Sandra, Zhou, Qiao, Drake, Jennifer, Slape, Cynthia, Fernando, Paolo, Rida, Wasima, Kaltcheva, Teodora, Grifoni, Alba, Sette, Alessandro, Patterson, Angela, Dempsey, Shannon, Ball, Brian, Ali, Haris, Salhotra, Amandeep, Stein, Anthony, Nathwani, Nitya, Rosenzweig, Michael, Nikolaenko, Liana, Al Malki, Monzr M., Dickter, Jana, Nanayakkara, Deepa D., Puing, Alfredo, Forman, Stephen J., Taplitz, Randy A., Zaia, John A., Nakamura, Ryotaro, Wussow, Felix, Diamond, Don J., Dadwal, Sanjeet S.“…As part of the safety lead-in portion of a phase 2 clinical trial in patients post HCT/CAR-T for hematological malignancies (HM), we tested the immunogenicity of the synthetic modified vaccinia Ankara-based COVID-19 vaccine COH04S1 co-expressing spike (S) and nucleocapsid (N) antigens. …”
Publicado 2023
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876por Do, Kim Thi Hoang, Willenzon, Stefanie, Ristenpart, Jasmin, Janssen, Anika, Volz, Asisa, Sutter, Gerd, Förster, Reinhold, Bošnjak, Berislav“…BACKGROUND AND AIMS: Modified Vaccinia virus Ankara (MVA) represents a promising vaccine vector for respiratory administration to induce protective lung immunity including tertiary lymphoid structure, the bronchus-associated lymphoid tissue (BALT). …”
Publicado 2023
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877por Nettere, Danielle, Unnithan, Shakthi, Rodgers, Nicole, Nohara, Junsuke, Cray, Paul, Berry, Madison, Jones, Caroline, Armand, Lawrence, Li, Shuk Hang, Berendam, Stella J., Fouda, Genevieve G., Cain, Derek W., Spence, Taylor N., Granek, Joshua A., Davenport, Clemontina A., Edwards, Robert J., Wiehe, Kevin, Van Rompay, Koen K. A., Moody, M. Anthony, Permar, Sallie R., Pollara, Justin“…To test this, we developed an innovative conjugate vaccine regimen that used a modified vaccinia virus Ankara (MVA) co-expressing HIV-1 envelope (Env) and the hepatitis B virus surface antigen (HBsAg) as a prime, followed by two Env–HBsAg conjugate protein boosts. …”
Publicado 2023
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878por Bråve, Andreas, Gudmundsdotter, Lindvi, Gasteiger, Georg, Hallermalm, Kristian, Kastenmuller, Wolfgang, Rollman, Erik, Boberg, Andreas, Engström, Gunnel, Reiland, Sven, Cosma, Antonio, Drexler, Ingo, Hinkula, Jorma, Wahren, Britta, Erfle, Volker“…Based on these findings we performed a long-term toxicity and immunogenicity study of Nef, encoded either by Modified Vaccinia virus Ankara or by plasmid DNA. BALB/c mice were primed twice with either DNA or MVA encoding Nef and received a homologous or heterologous boost ten months later. …”
Publicado 2007
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879por Bridge, Simon H, Sharpe, Sally A, Dennis, Mike J, Dowall, Stuart D, Getty, Brian, Anson, Donald S, Skinner, Michael A, Stewart, James P, Blanchard, Tom J“…METHODS: Three Chinese cynomolgus macaques were immunised via intramuscular injections using a regimen composed of a prime with two DNA vaccines expressing clade A Env/clade B Gag followed by boosting with recombinant fowlpox virus expressing HIV-1 clade D Gag, Env and cholera toxin B subunit followed by the final boost with recombinant modified vaccinia virus Ankara expressing HIV-1 clade C Env, Gag and human complement protein C3d. …”
Publicado 2011
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880por Sheehy, Susanne H., Duncan, Christopher J. A., Elias, Sean C., Biswas, Sumi, Collins, Katharine A., O'Hara, Geraldine A., Halstead, Fenella D., Ewer, Katie J., Mahungu, Tabitha, Spencer, Alexandra J., Miura, Kazutoyo, Poulton, Ian D., Dicks, Matthew D. J., Edwards, Nick J., Berrie, Eleanor, Moyle, Sarah, Colloca, Stefano, Cortese, Riccardo, Gantlett, Katherine, Long, Carole A., Lawrie, Alison M., Gilbert, Sarah C., Doherty, Tom, Nicosia, Alfredo, Hill, Adrian V. S., Draper, Simon J.“…METHODOLOGY: We conducted a Phase Ia, non-randomized clinical trial in 16 healthy, malaria-naïve adults of the chimpanzee adenovirus 63 (ChAd63) and modified vaccinia virus Ankara (MVA) replication-deficient viral vectored vaccines encoding two alleles (3D7 and FVO) of the P. falciparum blood-stage malaria antigen; apical membrane antigen 1 (AMA1). …”
Publicado 2012
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