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141por Liu, Ruikang, Mendez-Rios, Jorge D., Peng, Chen, Xiao, Wei, Weisberg, Andrea S., Wyatt, Linda S., Moss, Bernard“…Modified vaccinia virus Ankara (MVA) is the leading poxvirus vector for development of vaccines against diverse infectious diseases. …”
Publicado 2019
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142por Routhu, Nanda Kishore, Gangadhara, Sailaja, Lai, Lilin, Davis Gardner, Meredith Elizabeth, Floyd, Katharine, Shiferaw, Ayalnesh, Bartsch, Yannic C, Fischinger, Stephanie, Khoury, Georges, Rahman, Sheikh Abdul, Stampfer, Samuel David, Schaefer, Alexandra, Jean, Sherrie M., Wallace, Chelsea, Stammen, Rachelle L., Wood, Jennifer, Cohen, Joyce, Nagy, Tamas, Parsons, Matthew S., Gralinski, Lisa, Kozlowski, Pamela A., Alter, Galit, Suthar, Mehul S., Amara, Rama Rao“…Here, we inactivated the furin-cleavage site (FCS) of spike expressed by a modified vaccinia Ankara (MVA) virus vaccine (MVA/SdFCS) and found that FCS inactivation markedly increased spike binding to human ACE2. …”
Publicado 2022
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143por Malherbe, Delphine C., Domi, Arban, Hauser, Mary J., Atyeo, Caroline, Fischinger, Stephanie, Hyde, Matthew A., Williams, Julie M., Alter, Galit, Guirakhoo, Farshad, Bukreyev, Alexander“…A new vectored vaccine MVA-VLP-SUDV was generated against Sudan ebolavirus (SUDV) combining the advantages of the immunogenicity of a live attenuated vaccine vector (Modified Vaccinia Ankara, MVA) with the authentic conformation of virus-like particles (VLPs). …”
Publicado 2022
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144por Frey, Sharon E., Wald, Anna, Edupuganti, Srilatha, Jackson, Lisa A., Stapleton, Jack T., Sahly, Hana El, El-Kamary, Samer S., Edwards, Kathryn, Keyserling, Harry, Winokur, Patricia, Keitel, Wendy, Hill, Heather, Goll, Johannes B., Anderson, Edwin L., Graham, Irene L., Johnston, Christine, Mulligan, Mark, Rouphael, Nadine, Atmar, Robert, Patel, Shital, Chen, Wilbur, Kotloff, Karen, Creech, C. Buddy, Chaplin, Paul, Belshe, Robert B.“…BACKGROUND: Modified vaccinia Ankara (MVA) is being developed as a safer smallpox vaccine and is being placed in the US Strategic National Stockpile (SNS) as a liquid formulation for subcutaneous (SC) administration at a dose of 1 × 10(8) TCID(50) in a volume of 0.5 mL. …”
Publicado 2015
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146por Wilken, Lucas, Stelz, Sonja, Agac, Ayse, Sutter, Gerd, Prajeeth, Chittappen Kandiyil, Rimmelzwaan, Guus F.“…Here, we modified DENV2 NS1 by mutating an N-linked glycosylation site associated with NS1-induced endothelial hyperpermeability and used modified vaccinia virus Ankara (MVA) as a vector for its delivery. The resulting construct, rMVA-D2-NS1-N207Q, displayed high genetic stability and drove efficient secretion of NS1-N207Q from infected cells. …”
Publicado 2023
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147por Ilchmann, Heiko, Samy, Nathaly, Reichhardt, Daniela, Schmidt, Darja, Powell, Jacqueline D, Meyer, Thomas P H, Silbernagl, Günter, Nichols, Rick, Weidenthaler, Heinz, De Moerlooze, Laurence, Chen, Liddy, Chaplin, Paul“…BACKGROUND: Although modified vaccinia Ankara-Bavarian Nordic (MVA-BN) vaccination is approved for smallpox and monkeypox prevention, immunological persistence and booster effects remain undescribed. …”
Publicado 2022
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148“…B14 shares 95 % amino acid identity with the 183 protein encoded by modified virus Ankara (MVA), an attenuated VACV strain being developed as a vaccine vector. …”
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149por Billeskov, Rolf, Christensen, Jan P., Aagaard, Claus, Andersen, Peter, Dietrich, Jes“…Here we report for the first time on the immunogenicity and protective efficacy of a vaccine strategy involving the adjuvanted fusion protein “H28” (consisting of Ag85B-TB10.4-Rv2660c) and Modified Vaccinia Virus Ankara expressing H28. We show that a heterologous prime-boost regimen involving priming with H28 in a Th1 adjuvant followed by boosting with H28 expressed by MVA (H28/MVA28) induced the highest percentage of IFN-γ expressing T cells, the highest production of IFN-γ per single cell and the highest induction of CD8 T cells compared to either of the vaccines given alone. …”
Publicado 2013
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150por Prabakaran, Mookkan, Leyrer, Sonja, He, Fang, Auer, Sebastian, Kumar, Subaschandrabose R., Kindsmueller, Kathrin, Mytle, Nutan, Schneider, Joerg, Lockhart, Stephen, Kwang, JimmyEnlace del recurso
Publicado 2014
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151por Knudsen, Maria L., Ljungberg, Karl, Tatoud, Roger, Weber, Jonathan, Esteban, Mariano, Liljeström, PeterEnlace del recurso
Publicado 2015
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152por Di Mario, Giuseppina, Sciaraffia, Ester, Facchini, Marzia, Gubinelli, Francesco, Soprana, Elisa, Panigada, Maddalena, Bernasconi, Valentina, Garulli, Bruno, Siccardi, Antonio, Donatelli, Isabella, Castrucci, Maria R.“…In the present study, modified vaccinia virus Ankara (MVA) encoding internal influenza antigens were evaluated for their immunogenicity and ability to protect HLA-A2.1 transgenic (AAD) mice from infection with influenza viruses. …”
Publicado 2017
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153por Domi, Arban, Feldmann, Friederike, Basu, Rahul, McCurley, Nathanael, Shifflett, Kyle, Emanuel, Jackson, Hellerstein, Michael S., Guirakhoo, Farshad, Orlandi, Chiara, Flinko, Robin, Lewis, George K., Hanley, Patrick W., Feldmann, Heinz, Robinson, Harriet L., Marzi, Andrea“…Here, we report the construction and preclinical efficacy testing of a novel recombinant modified vaccinia Ankara (MVA)-based vaccine expressing the EBOV-Makona glycoprotein GP and matrix protein VP40 (MVA-EBOV). …”
Publicado 2018
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154por Meseda, Clement A., Atukorale, Vajini, Soto, Jackeline, Eichelberger, Maryna C., Gao, Jin, Wang, Wei, Weiss, Carol D., Weir, Jerry P.“…We describe the construction of recombinant modified vaccinia virus Ankara (MVA) vectors expressing the hemagglutinin (HA) or neuraminidase (NA) from three H7 viruses representing both Eurasian and North American H7 lineages – A/mallard/Netherlands/12/2000 (H7N3), A/Canada/rv444/2004 (H7N3), and A/Shanghai/02/2013 (H7N9). …”
Publicado 2018
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155por Bathke, Barbara, Pätzold, Juliane, Kassub, Ronny, Giessel, Raphael, Lämmermann, Kerstin, Hinterberger, Maria, Brinkmann, Kay, Chaplin, Paul, Suter, Mark, Hochrein, Hubertus, Lauterbach, Henning“…We sought to investigate the role of CD70 co‐stimulation for immune responses induced by the vaccine vector modified vaccinia virus Ankara–Bavarian Nordic(®) (MVA‐BN (®)). Short‐term blockade of CD70 diminished systemic CD8 T‐cell effector and memory responses in mice. …”
Publicado 2018
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156por Pérez, Patricia, Q. Marín, María, Lázaro-Frías, Adrián, Jiménez de Oya, Nereida, Blázquez, Ana-Belén, Escribano-Romero, Estela, S. Sorzano, Carlos Óscar, Ortego, Javier, Saiz, Juan-Carlos, Esteban, Mariano, Martín-Acebes, Miguel A., García-Arriaza, Juan“…In this study, we have developed and characterized the immunogenicity and efficacy of a novel ZIKV vaccine based on the highly attenuated poxvirus vector modified vaccinia virus Ankara (MVA) expressing the ZIKV prM and E structural genes (termed MVA-ZIKV). …”
Publicado 2018
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157por Salvato, Maria S., Domi, Arban, Guzmán-Cardozo, Camila, Medina-Moreno, Sandra, Zapata, Juan Carlos, Hsu, Haoting, McCurley, Nathanael, Basu, Rahul, Hauser, Mary, Hellerstein, Michael, Guirakhoo, Farshad“…Constructed in the Modified Vaccinia Ankara (MVA) vector, GEO-LM01 expresses the glycoprotein precursor (GPC) and zinc-binding matrix protein (Z) from the prototype Josiah strain lineage IV. …”
Publicado 2019
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158por Anderson, Evan J., Lai, Lilin, Wrammert, Jens, Kabbani, Sarah, Xu, Yongxian, Priyamvada, Lalita, Hill, Heather, Goll, Johannes B., Jensen, Travis L., Kao, Carol, Yildirim, Inci, Rouphael, Nadine, Jackson, Lisa, Mulligan, Mark J.“…Plasmablast, circulating follicular helper T (cT(FH)) cells, cytokine-expressing CD4 T cells, and memory B cells were compared between subcutaneous (SC) and needle-free jet injection (JI) recipients of non-replicating modified vaccinia Ankara (MVA) vaccine. Methods: Vaccinia-naïve adults received MVA SC or by JI on Days 1 and 29. …”
Publicado 2020
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159por Koch, Till, Dahlke, Christine, Fathi, Anahita, Kupke, Alexandra, Krähling, Verena, Okba, Nisreen M A, Halwe, Sandro, Rohde, Cornelius, Eickmann, Markus, Volz, Asisa, Hesterkamp, Thomas, Jambrecina, Alen, Borregaard, Saskia, Ly, My L, Zinser, Madeleine E, Bartels, Etienne, Poetsch, Joseph S H, Neumann, Reza, Fux, Robert, Schmiedel, Stefan, Lohse, Ansgar W, Haagmans, Bart L, Sutter, Gerd, Becker, Stephan, Addo, Marylyn M“…We aimed to assess safety and tolerability of an anti-MERS-CoV modified vaccinia virus Ankara (MVA)-based vaccine candidate that expresses the MERS-CoV spike glycoprotein, MVA-MERS-S, in healthy adults. …”
Publicado 2020
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160por Routhu, Nanda Kishore, Cheedarla, Narayanaiah, Gangadhara, Sailaja, Bollimpelli, Venkata Satish, Boddapati, Arun K., Shiferaw, Ayalnesh, Rahman, Sheikh Abdul, Sahoo, Anusmita, Edara, Venkata Viswanadh, Lai, Lilin, Floyd, Katharine, Wang, Shelly, Fischinger, Stephanie, Atyeo, Caroline, Shin, Sally A., Gumber, Sanjeev, Kirejczyk, Shannon, Cohen, Joyce, Jean, Sherrie M., Wood, Jennifer S., Connor-Stroud, Fawn, Stammen, Rachelle L., Upadhyay, Amit A., Pellegrini, Kathryn, Montefiori, David, Shi, Pei-Yong, Menachery, Vineet D., Alter, Galit, Vanderford, Thomas H., Bosinger, Steven E., Suthar, Mehul S., Amara, Rama Rao“…Here, we show that modified vaccinia Ankara (MVA) vectors expressing membrane-anchored pre-fusion stabilized spike (MVA/S) but not secreted S1 induced strong neutralizing antibody responses against SARS-CoV-2 in mice. …”
Publicado 2021
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