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41por Van Sciver, Robert E., Long, Alyssa B., Katz, Harrison G., Gigante, Eduardo D., Caspary, Tamara“…ARL13B is a small GTPase enriched in cilia. Deletion of Arl13b in mouse kidney results in renal cysts and an associated absence of primary cilia. …”
Publicado 2023
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43“…RESULTS: We determined the complete genome sequence of Micavibrio aeruginosavorus ARL-13, an obligate bacterial predator that feeds by "leeching" externally to its prey. …”
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44por Larkins, Christine E., Aviles, Gladys D. Gonzalez, East, Michael P., Kahn, Richard A., Caspary, Tamara“…In this paper, we further characterize the role of Arl13b in cilia by examining mutant cilia in vitro and determining the localization and dynamics of Arl13b within the cilium. …”
Publicado 2011
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45“…Conversely, constitutively SUMOylated ARL-13 fully rescues all ciliary defects of arl-13–null animals. …”
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47por Newman, Laura E., Zhou, Cheng-jing, Mudigonda, Samatha, Mattheyses, Alexa L., Paradies, Eleonora, Marobbio, Carlo Marya Thomas, Kahn, Richard A.“…Rather, we found that knockdown of the ARL2 GTPase activating protein (GAP) ELMOD2 phenocopies two of three phenotypes of ARL2 siRNA, making it a likely effector for these actions. …”
Publicado 2014
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48por Lokaj, Mandy, Kösling, Stefanie K., Koerner, Carolin, Lange, Sven M., van Beersum, Sylvia E.C., van Reeuwijk, Jeroen, Roepman, Ronald, Horn, Nicola, Ueffing, Marius, Boldt, Karsten, Wittinghofer, Alfred“…It recognizes an LLxILxxL motif at the N-terminal amphipathic helix of Arl3, which is crucial for the interaction with the BART-like domain but also for the ciliary localization of Arl3 itself. …”
Publicado 2015
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49por Alkanderi, Sumaya, Molinari, Elisa, Shaheen, Ranad, Elmaghloob, Yasmin, Stephen, Louise A., Sammut, Veronica, Ramsbottom, Simon A., Srivastava, Shalabh, Cairns, George, Edwards, Noel, Rice, Sarah J., Ewida, Nour, Alhashem, Amal, White, Kathryn, Miles, Colin G., Steel, David H., Alkuraya, Fowzan S., Ismail, Shehab, Sayer, John A.“…We propose that ARL3 provides a potential hub in the network of proteins implicated in ciliopathies, whereby perturbation of ARL3 leads to the mislocalization of multiple ciliary proteins as a result of abnormal displacement of lipidated protein cargo.…”
Publicado 2018
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50por Ouyang, Zhenlin, Zheng, Fang, Chew, Jared Y, Pei, Yingmei, Zhou, Jinhong, Wen, Keqing, Han, Miao, Lemieux, M Joanne, Hwang, Peter M, Wen, Yurong“…Staphylococcus aureus ArlRS is a key two-component regulatory system necessary for adhesion, biofilm formation, and virulence. …”
Publicado 2019
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51por Sheikh, Shakeel A., Sisk, Robert A., Schiavon, Cara R., Waryah, Yar M., Usmani, Muhammad A., Steel, David H., Sayer, John A., Narsani, Ashok K., Hufnagel, Robert B., Riazuddin, Saima, Kahn, Richard A., Waryah, Ali M., Ahmed, Zubair M.“…The functional studies on the bacterial and heterologous mammalian cells revealed that the arginine at position 99 is essential for the stability of ARL3. CONCLUSIONS: Our study uncovers an additional CRD gene and assigns the CRD phenotype to a variant of ARL3. …”
Publicado 2019
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53“…Treatment of cells with 1 mM H(2)O(2) for 10 min resulted in the degradation of Arl1 and dissociation of GRIP domain–containing proteins Golgin-97 and Golgin-245 from the trans-Golgi. …”
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54por ElMaghloob, Yasmin, Sot, Begoña, McIlwraith, Michael J, Garcia, Esther, Yelland, Tamas, Ismail, Shehab“…ARL3 is activated by its guanine exchange factor (GEF) ARL13B via an unresolved mechanism. …”
Publicado 2021
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55“…Interestingly, Arfrp1 and Arl14 are recruited to their specific cellular compartments independent of GTP binding. …”
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56por Zhang, Binbin, Xu, Aiqun, Wu, Dong, Xia, Wanli, Li, Pulin, Wang, Enze, Han, Rui, Sun, Peng, Zhou, Sijing, Wang, Ran“…Kaplan–Meier analysis was conducted to evaluate the prognostic value of ARL14 in NSCLC. Functions of ARL14 were identified by enrichment analysis. …”
Publicado 2021
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57“…Recent work found that ARL8, a known anterograde adaptor linking the lysosome to kinesin, also links lysosomes to the retrograde motor dynein, providing key insight into bidirectional organelle movement in cells.…”
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58por Kahn, Richard A., Cherfils, Jacqueline, Elias, Marek, Lovering, Ruth C., Munro, Sean, Schurmann, Annette“…The Arf family includes three different groups of proteins: the Arfs, Arf-like (Arls), and SARs. Several Arf family members have been very highly conserved throughout eukaryotic evolution and have orthologues in evolutionally diverse species. …”
Publicado 2006
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59por Pretorius, Pamela R., Baye, Lisa M., Nishimura, Darryl Y., Searby, Charles C., Bugge, Kevin, Yang, Baoli, Mullins, Robert F., Stone, Edwin M., Sheffield, Val C., Slusarski, Diane C.“…We have identified a novel transcript of a known BBS gene, BBS3 (ARL6), which includes an additional exon. This transcript, BBS3L, is evolutionally conserved and is expressed predominantly in the eye, suggesting a specialized role in vision. …”
Publicado 2010
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60“…BACKGROUND: Although the embryonic expression pattern of ADP ribosylation factor-like 6 interacting protein 1 (Arl6ip1) has been reported, its function in neural crest development is unclear. …”
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