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Mostrando 61 - 80 Resultados de 1,286 Para Buscar '"Arlés"', tiempo de consulta: 0.17s Limitar resultados
  1. 61
    “…ARL4D, ARL4A, and ARL4C are closely related members of the ADP-ribosylation factor/ARF-like protein (ARF/ARL) family of GTPases. …”
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    Online Artículo Texto
    GTP-Binding-Defective ARL4D Alters Mitochondrial Morphology and Membrane Potential
  2. 62
    “…Furthermore, we have also identified that the Arl8b effector SKIP (also known as PLEKHM2) interacts with and recruits HOPS subunits to Arl8b and kinesin-positive peripheral lysosomes. …”
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    Online Artículo Texto
    The small GTPase Arl8b regulates assembly of the mammalian HOPS complex on lysosomes
  3. 63
    “…The regulatory GTPase Arl13b localizes to primary cilia, where it regulates Sonic hedgehog (Shh) signaling. …”
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    Arl13b regulates Shh signaling from both inside and outside the cilium
  4. 64
    “…However, the biological functional role of ARL2 in glioma still remains unknown. The aim of this study was to explore the expression and functional role of ARL2 in glioma. …”
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    ARL2 overexpression inhibits glioma proliferation and tumorigenicity via down-regulating AXL
  5. 65
    “…In this study, ARF-like GTPase 14 (ARL14) was screened as an important prognostic factor of lung adenocarcinoma from The Cancer Genome Atlas (TCGA) database and validated by our in vitro experiments. …”
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    Silencing of ARL14 Gene Induces Lung Adenocarcinoma Cells to a Dormant State
  6. 66
    “…ARL13B is a regulatory GTPase highly enriched in cilia. …”
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    Online Artículo Texto
    ARL13B regulates Sonic hedgehog signaling from outside primary cilia
  7. 67
    “…We found that knockdown or knockout of arl13b impaired balance and locomotion in zebrafish larvae. …”
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    Online Artículo Texto
    The Joubert Syndrome Gene arl13b is Critical for Early Cerebellar Development in Zebrafish
  8. 68
    “…Our results, identifying a novel pathogenic variant in ARL3 in a four-generation family with a dominant IRD, augment the evidence that the ARL3 gene is another cause of non-syndromic retinal degeneration.…”
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    A Novel ARL3 Gene Mutation Associated With Autosomal Dominant Retinal Degeneration
  9. 69
    “…Our study found that all 22 ARLs are differentially expressed in CM. Specifically, ARL1 and ARL11 are upregulated and ARL15 is downregulated regardless of mutational frequency or copy number variations. …”
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    Unraveling the Relevance of ARL GTPases in Cutaneous Melanoma Prognosis through Integrated Bioinformatics Analysis
  10. 70
    “…We set out to understand the role of ARL15 in adipogenesis and showed that endogenous ARL15 palmitoylated and localised in the Golgi of mouse liver. …”
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    Palmitoylated small GTPase ARL15 is translocated within Golgi network during adipogenesis
  11. 71
    “…ARL2 regulates the dynamics of cytological components and is highly expressed in colon cancer tissues. …”
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    Online Artículo Texto
    ARL2 is required for homologous recombination repair and colon cancer stem cell survival
  12. 72
    “…Our observations suggest that Smad4 functions as an effector and a GTPase activating protein (GAP) of Arl15. Assembly of the Smad-complex enhances the GAP activity of Smad4 toward Arl15, therefore dissociating Arl15 before the nuclear translocation of the Smad-complex. …”
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    Arl15 upregulates the TGFβ family signaling by promoting the assembly of the Smad-complex
  13. 73
    “…In conclusion, the loss of Chlamydomonas ARL13 impedes BBSome-dependent protein transport, resulting in overlapping biochemical defects in arl13 and bbs mutant cilia.…”
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    Loss of ARL13 impedes BBSome-dependent cargo export from Chlamydomonas cilia
  14. 74
    “…We discovered that dominant mutations result in increased active G-protein—Arl3-D67V has constitutive activity and Arl3-Y90C is fast cycling—and their expression in mouse rods resulted in a displaced nuclear phenotype due to an aberrant Arl3-GTP gradient. …”
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    Disrupting the ciliary gradient of active Arl3 affects rod photoreceptor nuclear migration
  15. 75
    “…BACKGROUND: ARL9 is a newly identified member of the ARF family, and the clinical significance of ARL9 in colon adenocarcinoma is unknown. …”
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    ARL9 is upregulated and serves as a biomarker for a poor prognosis in colon adenocarcinoma
  16. 76
    por Richards, J. Brent, Waterworth, Dawn, O'Rahilly, Stephen, Hivert, Marie-France, Loos, Ruth J. F., Perry, John R. B., Tanaka, Toshiko, Timpson, Nicholas John, Semple, Robert K., Soranzo, Nicole, Song, Kijoung, Rocha, Nuno, Grundberg, Elin, Dupuis, Josée, Florez, Jose C., Langenberg, Claudia, Prokopenko, Inga, Saxena, Richa, Sladek, Robert, Aulchenko, Yurii, Evans, David, Waeber, Gerard, Erdmann, Jeanette, Burnett, Mary-Susan, Sattar, Naveed, Devaney, Joseph, Willenborg, Christina, Hingorani, Aroon, Witteman, Jaquelin C. M., Vollenweider, Peter, Glaser, Beate, Hengstenberg, Christian, Ferrucci, Luigi, Melzer, David, Stark, Klaus, Deanfield, John, Winogradow, Janina, Grassl, Martina, Hall, Alistair S., Egan, Josephine M., Thompson, John R., Ricketts, Sally L., König, Inke R., Reinhard, Wibke, Grundy, Scott, Wichmann, H-Erich, Barter, Phil, Mahley, Robert, Kesaniemi, Y. Antero, Rader, Daniel J., Reilly, Muredach P., Epstein, Stephen E., Stewart, Alexandre F. R., Van Duijn, Cornelia M., Schunkert, Heribert, Burling, Keith, Deloukas, Panos, Pastinen, Tomi, Samani, Nilesh J., McPherson, Ruth, Davey Smith, George, Frayling, Timothy M., Wareham, Nicholas J., Meigs, James B., Mooser, Vincent, Spector, Tim D.
    Publicado 2009
    “…Expression studies in humans indicated that ARL15 is well-expressed in skeletal muscle. These findings identify a novel protein, ARL15, which influences circulating adiponectin levels and may impact upon CHD risk.…”
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    A Genome-Wide Association Study Reveals Variants in ARL15 that Influence Adiponectin Levels
  17. 77
    “…Loss of arl-8 results in an increase in the number of late endosomal/lysosomal compartments, which are smaller than wild type. …”
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    The Arf-like GTPase Arl8 Mediates Delivery of Endocytosed Macromolecules to Lysosomes in Caenorhabditis elegans
  18. 78
    “…Furthermore, recombinant human GST-ELMOD3 exhibited GTPase activating protein (GAP) activity against the Arl2 GTPase, which was completely abolished by the p.Leu265Ser mutation. …”
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    An Alteration in ELMOD3, an Arl2 GTPase-Activating Protein, Is Associated with Hearing Impairment in Humans
  19. 79
    “…We found that the ebh gene, encoding the Giant Staphylococcal Surface Protein (GSSP), was up-regulated in an arlRS mutant. By introducing an ebh complete deletion into an arlRS mutant, agglutination was restored. …”
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    The Staphylococcus aureus ArlRS Two-Component System Is a Novel Regulator of Agglutination and Pathogenesis
  20. 80
    “…In this study, we investigated two single nucleotide polymorphisms (SNPs), rs4311394 and rs4783244, located intronically in the ADP-ribosylation factor-like protein 15 (ARL15) and the T-cadherin (CDH13) genes, respectively. …”
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    Association Study of ARL15 and CDH13 with T2DM in a Han Chinese Population
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