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Mostrando 81 - 100 Resultados de 1,286 Para Buscar '"Arlés"', tiempo de consulta: 0.29s Limitar resultados
  1. 81
    “…The trans-Golgi-specific targeting of BIG1 and BIG2 depends on the Arf-like GTPase Arl1. We find that Arl1 binds to the dimerization and cyclophilin binding (DCB) domain in BIG1 and report a crystal structure of human Arl1 bound to this domain. …”
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    Structural Insights into Arl1-Mediated Targeting of the Arf-GEF BIG1 to the trans-Golgi
  2. 82
    por Yang, Shu, Rosenwald, Anne G.
    Publicado 2016
    “…Here we demonstrate that 2 monomeric GTP-binding proteins in Saccharomyces cerevisiae, Arl1 and Ypt6, which belong to the Arf/Arl/Sar protein family and the Rab family, respectively, and control endosome-trans-Golgi traffic, are also necessary for starvation-induced autophagy under high temperature stress. …”
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    Autophagy in Saccharomyces cerevisiae requires the monomeric GTP-binding proteins, Arl1 and Ypt6
  3. 83
    Publicado 2017
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    Correction for Arl13b regulates Shh signaling from both inside and outside the cilium
  4. 84
    “…RESULTS: Homozygous variants in ARL2BP (NM_012106.3) were identified in two unrelated individuals with RP. …”
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    Novel homozygous splicing mutations in ARL2BP cause autosomal recessive retinitis pigmentosa
  5. 85
    “…The small GTPase Arl13b is one of the most conserved and ancient ciliary proteins. …”
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    The unusual flagellar-targeting mechanism and functions of the trypanosome ortholog of the ciliary GTPase Arl13b
  6. 86
    “…By testing components of the AA-stimulated mTORC1 signaling pathway, we demonstrate that SLC38A9, v-ATPase and Ragulator, but not Rag GTPases and mTORC1, are essential for the AA-stimulated trafficking. Arl5, an ARF-like family small GTPase, interacts with Ragulator in an AA-regulated manner and both Arl5 and its effector, the Golgi-associated retrograde protein complex (GARP), are required for the AA-stimulated trafficking. …”
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    Amino acids stimulate the endosome-to-Golgi trafficking through Ragulator and small GTPase Arl5
  7. 87
    “…Finally, we demonstrated that the ArlRS—MgrA regulatory cascade is a druggable target through the identification of a small-molecule inhibitor of ArlRS signaling. …”
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    Staphylococcus aureus adhesion in endovascular infections is controlled by the ArlRS–MgrA signaling cascade
  8. 88
    “…Here we demonstrate that ELMOD2, an ARL2 GTPase-activating protein (GAP), is necessary for ARL2 to promote mitochondrial elongation. …”
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    ELMOD2 regulates mitochondrial fusion in a mitofusin-dependent manner, downstream of ARL2
  9. 89
    “…In this study, the involvement of ADP‐ribosylation factor (ARF)‐like (ARL) 4C (ARL4C), a member of the small GTP‐binding protein family, in the progression of lung adenocarcinoma and the possibility of ARL4C as a molecular target for lung cancer therapy were explored. …”
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    ARL4C is associated with initiation and progression of lung adenocarcinoma and represents a therapeutic target
  10. 90
    “…There are a growing number of genetic causes for these rare syndromes, including the recently described genes ARL3 and CEP120. METHODS: We sought to explore the developmental expression patterns of ARL3 and CEP120 in humans to gain additional understanding of these genetic conditions. …”
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    Expression patterns of ciliopathy genes ARL3 and CEP120 reveal roles in multisystem development
  11. 91
    “…Mechanistically, miR-145 inhibited mitochondrial function by targeting ARL5B directly. Futhermore, miR-145 overexpression decreased ARL5B expression in ovarian cancer tissue subcutaneous tumors of nude mice. …”
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    miR-145 inhibits mitochondrial function of ovarian cancer by targeting ARL5B
  12. 92
    “…However, the biological function of ARL2 in CRC remains unclear. The present study was performed to identify the expression level and functional role of ARL2 in CRC. …”
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    Regulation of ARL2 in colorectal cancer cell proliferation and tumorigenicity, and its negative association with AXL
  13. 93
    “…Purpose: ARL3 (ADP-ribosylation factor-like 3) variants cause autosomal dominant retinitis pigmentosa (RP) or autosomal recessive Joubert syndrome. …”
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    Autosomal Recessive Rod-Cone Dystrophy Associated With Compound Heterozygous Variants in ARL3 Gene
  14. 94
    “…We discovered a role for both ArlRS and VraSR TCS as determinants responsible for MW2 survival in the presence of sub-MIC ceftaroline. …”
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    The Role of ArlRS and VraSR in Regulating Ceftaroline Hypersusceptibility in Methicillin-Resistant Staphylococcus aureus
  15. 95
    “…These studies thus identify RUFY3 and RUFY4 as ARL8-dependent, dynein-dynactin adaptors or regulators, and highlight the role of ARL8 in the control of both anterograde and retrograde endolysosome transport.…”
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    RUFY3 and RUFY4 are ARL8 effectors that promote coupling of endolysosomes to dynein-dynactin
  16. 96
    por Anderson, Jacob, Walker, Gerard, Pu, Jing
    Publicado 2022
    “…Our study demonstrates that the BORC-ARL8-HOPS ensemble is required for cholesterol egress from lysosomes by enabling CI–MPR-dependent trafficking of NPC2 to the endosomal-lysosomal system.…”
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    BORC-ARL8-HOPS ensemble is required for lysosomal cholesterol egress through NPC2
  17. 97
    “…The crystal structure of the complex between ARL15 GTPase domain and CNNM2 CBS-pair domain reveals the molecular determinants of the interaction and allowed the identification of mutations in ARL15 and CNNM2 mutations that abrogate binding. …”
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    Structural insights into regulation of TRPM7 divalent cation uptake by the small GTPase ARL15
  18. 98
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    Les variants colorés en race Mérinos d'Arles I. Étude de la génération parentale
  19. 99
    “…Here, we characterize ARL15 as a GTP and CNNM-binding protein and demonstrate that ARL15 also inhibits CNNM2 Mg(2+) efflux. …”
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    Structural insights into regulation of CNNM-TRPM7 divalent cation uptake by the small GTPase ARL15
  20. 100
    “…Impaired Arl4A-VPS36 interaction enhances EGFR degradation and clearance of EGFR ubiquitinylation. …”
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    Endosomal Arl4A attenuates EGFR degradation by binding to the ESCRT-II component VPS36
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