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401por Jiang, Xin, Gao, Yu-lu, Li, Jia-yan, Tong, Ying-ying, Meng, Zhao-yang, Yang, Shi-gui, Zhu, Chang-tai“…Pearson correlation analysis was performed to identify ARLs. LASSO and Cox regression were then used to establish a prognostic risk signature for ARLs. …”
Publicado 2023
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402por Párraga Solórzano, Paola K., Yao, Jiangwei, Rock, Charles O., Kehl-Fie, Thomas E.“…In this work, expression analysis revealed that manganese starvation imposed by the immune effector calprotectin or by the absence of glycolytic substrates activates ArlRS. Manganese starvation imposed by calprotectin also activated the ArlRS system even when glycolytic substrates were present. …”
Publicado 2019
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403por Sterpka, Ashley, Yang, Juan, Strobel, Matthew, Zhou, Yuxin, Pauplis, Connor, Chen, Xuanmao“…In a cortical injury model, Arl13b is not detectable in primary cilia, but Arl13b protein relocates to the cell body and has robust expression in the proximity of injured tissues. …”
Publicado 2020
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404“…Silencing ARL2 in hESC-NPCs provoked an apoptotic phenotype resembling that of miR-195 overexpression, revealing for the first time an essential role of ARL2 for the survival of human NPCs. …”
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405Publicado 2017“…OBJECTIVE: To analyze the clinical characteristics, pathological features and survival of patients with AIDS related non-Hodgkin's lymphoma (ARL). METHODS: The clinical data of 53 ARL cases diagnosed and received care at Zhongnan hospital of Wuhan University were retrospectively studied, and 106 controls were enrolled as control group according to 1∶2 for paired cases and control. …”
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406por Geers, Bernd, Hagenstein, Julia, Endig, Jessica, Ulrich, Hanna, Fleig, Laura, Sprezyna, Paulina, Mikulec, Julita, Heukamp, Lukas, Tiegs, Gisa, Diehl, Linda“…Using global knockout and cell-specific knockout mouse models, we evaluated the role of the small GTPase ADP-ribosylation factor 4d (Arl4d) in regulatory T-cell biology. We show that the expression of Arl4d in T cells restricts both IL-2 production and responsiveness to IL-2, as measured by the phosphorylation of STAT5. …”
Publicado 2022
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407por Crosby, Heidi A., Schlievert, Patrick M., Merriman, Joseph A., King, Jessica M., Salgado-Pabón, Wilmara, Horswill, Alexander R.“…In this work we show that ArlRS does not directly regulate Ebh, but instead ArlRS activates expression of the global regulator MgrA. …”
Publicado 2016
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408por Zhou, Shuguang, Zhang, Weiyu, Cao, Wujun, Jin, Qinqin, Jiang, Xiya, Jiang, Xiaomin, Yang, Yinting, Yao, Hui, Chen, Guo, Gao, Wei, Zhu, Yuting, Qi, Jian, Tong, Zhuting“…Results indicated that the three prognostic ARLs (SMURF2P1, MIR9-3HG, and AC005332.4) possessed significant diversity and constituted the ARL signature. …”
Publicado 2022
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409por Suiwal, Shweta, Dembla, Mayur, Schwarz, Karin, Katiyar, Rashmi, Jung, Martin, Carius, Yvonne, Maxeiner, Stephan, Lauterbach, Marcel A., Lancaster, C. Roy D., Schmitz, Frank“…This transport activity is regulated by the GTPase Arl3 as well as by Arl13b and Rp2 that control Arl3 activation/inactivation. …”
Publicado 2022
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410por Wang, Ya-Wen, Liu, Can, Chen, Yan-Duo, Yang, Bin, Chen, Xu, Ma, Guangxin, Tian, Ya-Ru, Bo, Xiangkun, Zhang, Kai“…Considering the unknown association of angiogenesis and lncRNAs in breast cancer, we aim to identify angiogenesis-related lncRNAs (ARLs) and explore their prognostic value. Here, based on analysis of The Cancer Genome Atlas database, the correlation between ARL and the prognosis and immune infiltration landscape of breast cancer were investigated. …”
Publicado 2023
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411por Stephen, Louise A., ElMaghloob, Yasmin, McIlwraith, Michael J., Yelland, Tamas, Castro Sanchez, Patricia, Roda-Navarro, Pedro, Ismail, Shehab“…We describe a trafficking mechanism whereby UNC119A extracts membrane-bound LCK by sequestering the hydrophobic myristoyl group, followed by release at the target membrane under the control of the ciliary ARL3/ARL13B. The UNC119A N terminus acts as a “regulatory arm” by binding the LCK kinase domain, an interaction inhibited by LCK Y394 phosphorylation, thus together with the ARL3/ARL13B machinery ensuring immune synapse focusing of active LCK. …”
Publicado 2018
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412por Yang, Shuang, Bahl, Kriti, Chou, Hui-Ting, Woodsmith, Jonathan, Stelzl, Ulrich, Walz, Thomas, Nachury, Maxence V“…Here, we present the near-atomic structures of the BBSome by itself and in complex with ARL6(GTP), and we describe the changes in BBSome conformation induced by ARL6(GTP) binding. …”
Publicado 2020
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413“…In yeast, ER stress-enhances Arl1 activation and Golgin Imh1 recruitment to the late-Golgi. …”
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414“…It is shown that false alarms frequently happen much earlier than the in-control ARL (ARL(0)), and small shifts are often detected earlier compared to the ARL(1). …”
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415por Byrne, Dwayne J., Garcia-Pardo, M. Elena, Cole, Nelson B., Batnasan, Belguun, Heneghan, Sophia, Sohail, Anood, Blackstone, Craig, O’Sullivan, Niamh C.“…Loss of Arl6IP1 in Drosophila results in progressive locomotor deficits, emulating a key aspect of HSP in patients. …”
Publicado 2022
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416por Fansa, Eyad Kalawy, Kösling, Stefanie Kristine, Zent, Eldar, Wittinghofer, Alfred, Ismail, Shehab“…High-affinity cargo is exclusively released by the ciliary transport regulator Arl3, while low-affinity cargo is released by Arl3 and its non-ciliary homologue Arl2. …”
Publicado 2016
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417por Neuwald, Andrew F“…Arl8 GTPases conserve residues that strikingly diverge from those typically found in other Arf/Arl GTPases and that form structural interactions suggestive of a novel interswitch toggle mechanism. …”
Publicado 2010
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418por Wu, Yang, Ma, Yue, Xu, Tao, Zhang, Qing-zhao, Bai, Jinna, Wang, Jiaxue, Zhu, Tao, Lou, Qiang, Götz, Friedrich, Qu, Di, Zheng, Chun-quan, Zhao, Ke-qing“…Meanwhile, the growth inhibition of nicotine on SE1457 was observed, and it was much less on ΔarlRS and restored by the arlRS complementation. …”
Publicado 2018
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419por Elsebaie, Essam Mohamed, El-Wakeil, Nora Hamdy Mouhamed, Khalil, Azhar Mostafa Mohamed, Bahnasy, Rasha M., Asker, Galila Ali, El-Hassnin, Marwa Fawzy, Ibraheim, Suzan S., El-Farsy, Marwa Fawzi Ahmed, Faramawy, Asmaa Antar, Essa, Rowida Younis, Badr, Mohamed Reda“…This study reports on the use of aqueous Rumex leaf extract (ARLE) in the synthesis of silver nanoparticles (ARLE-AgNPs) with versatile biological activities. …”
Publicado 2023
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420por Osberg, Camilla, Aksnes, Henriette, Ninzima, Sandra, Marie, Michaël, Arnesen, Thomas“…The Saccharomyces cerevisiae protein Arl3 depends on interaction with Sys1 for its localization to the Golgi and this targeting strictly requires NatC-mediated N-terminal acetylation of Arl3. …”
Publicado 2016
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