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641por Epting, Daniel, Senaratne, Lokuliyange D. S., Ott, Elisabeth, Holmgren, Asbjørn, Sumathipala, Dulika, Larsen, Selma M., Wallmeier, Julia, Bracht, Diana, Frikstad, Kari‐Anne M., Crowley, Suzanne, Sikiric, Alma, Barøy, Tuva, Käsmann‐Kellner, Barbara, Decker, Eva, Decker, Christian, Bachmann, Nadine, Patzke, Sebastian, Phelps, Ian G., Katsanis, Nicholas, Giles, Rachel, Schmidts, Miriam, Zucknick, Manuela, Lienkamp, Soeren S., Omran, Heymut, Davis, Erica E., Doherty, Dan, Strømme, Petter, Frengen, Eirik, Bergmann, Carsten, Misceo, Doriana“…Furthermore, we observed reduced ability to ciliate, increased ciliary length, and reduced levels of the ciliary proteins AHI1 and ARL13B in patient fibroblasts. Our data show that CBY1 LOF‐variants cause a ciliopathy with features of Joubert syndrome.…”
Publicado 2020
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642“…Relying on the PAHs concentration values, on the consumption data and on the total toxic equivalent (TEQ), the incremental lifetime cancer risk (ILCR) was assessed and its calculated value (2.97 × 10(−7)) is far below the “maximum acceptable risk level” (ARL), suggesting a low potential carcinogenic risk on consuming M. surmuletus for local population. …”
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643“…Three DNA methylation-driven genes, ARL9, CMYA5, and STEAP3, were identified as independent prognostic factors. …”
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644
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645“…"Fundamental Astronomy and Solar System Dynamics", a program of invited papers honoring Professor Walter Fricke, who for thirty years has been Director of the Astronomisches Rechen lnstitut in Heidelberg, was held at the Thompson Conference Center of the University of Texas at Austin on Wednesday 27 March 1985 on the occasion of his seventieth birthday and retirement as Director of ARl. Professor Fricke's contributions to astronomy encompass the areas of galactic dynamics, radial velocities, stellar statistics. the fundamental reference system and the constant of precession. …”
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646por Aljiboury, Abrar A., Ingram, Eric, Krishnan, Nikhila, Ononiwu, Favour, Pal, Debadrita, Manikas, Julie, Taveras, Christopher, Hall, Nicole A., Da Silva, Jonah, Freshour, Judy, Hehnly, Heidi“…Once the intracellular cilia reach the CFTR positive apical membrane, Arl13b-positive cilia extend and elongate in a Rab8 dependent manner into the forming lumen once the lumen reaches an area of 300 μm(2). …”
Publicado 2023
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647por LaVan, David, Yi, Feng, Adams, Tina, Tao, Ran, Pelczar, Elizabeth, Xia, Han, Hu, Xiao, Sauerbrunn, Stephen, Matisons, Janis“…National Capital Area, on the DC metro system (allowing easy access to Washington museums and sites), and close to the National Institute of Standards and Technology (NIST), National Institutes of Health (NIH), Naval Research Laboratory (NRL), Army Research Laboratory (ARL), Johns Hopkins University Applied Physics Laboratory (JHU-APL), Naval Surface Warfare Center (NSWC), Georgetown University, George Washington University, George Mason University, and the University of Maryland. …”
Publicado 2023
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648“…The corresponding values for as-received lignin (ARL) were 1.20 wt %, 6000 g·mol(–1), and 2.22, respectively. …”
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649por Rushing, Blake R.“…Furthermore, copy number variant (CNV) analysis, derived from SNP data, between sensitive and resistant cells identified notable differences in genes associated with metabolic changes (WWOX, CNTN5, DDAH1, PGR), protein trafficking (ARL17B, VAT1L), and miRNAs (MIR1302-2, MIR3163, MIR1244-3, MIR1302-9). …”
Publicado 2023
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650por Sarwar, Muhammad Atif, Noor-ul-Amin, Muhammad, Khan, Imad, Ismail, Emad A. A., Sumelka, Wojciech, Nabi, Muhammad“…The effectiveness of the proposed chart is argued in terms of ARLs over the considered EWMA chart through Monte-Carlo (MC) simulation method. …”
Publicado 2023
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651“…However, treatment with microsomally activated AFB1 increased the level of activity in a cell line (BL8L) derived from normal liver with very low levels of GGT, by as much as 10-fold, and 5-fold in a cell line (ARL) also isolated from normal rat liver, but which had subsequently undergone spontaneous transformation. …”
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652por He, Mu-Lan, Gonzalez-Iglesias, Arturo E., Tomic, Melanija, Stojilkovic, Stanko S.“…Blocking the activity of eNTPDases by ARL67156 led to an increase in ATP release in perifused pituitary cells and inhibition of degradation of extracellularly added ATP. …”
Publicado 2005
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653“…We find that Rud3p is localized to the Golgi via a COOH-terminal domain that is distantly related to the GRIP domain that recruits several coiled-coil proteins to the trans-Golgi by binding the small Arf-like GTPase Arl1p. In contrast, Rud3p binds to the GTPase Arf1p via this COOH-terminal “GRIP-related Arf-binding” (GRAB) domain. …”
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654por Lai, Cary K., Gupta, Nidhi, Wen, Xiaohui, Rangell, Linda, Chih, Ben, Peterson, Andrew S., Bazan, J. Fernando, Li, Li, Scales, Suzie J.“…Validated hits include Ssa2 and mC21orf2 with ciliation defects; Ift46 with short cilia; Ptpdc1 and Iqub with elongated cilia; and Arl3, Nme7, and Ssna1 with distinct ciliary transport but not length defects. …”
Publicado 2011
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655por Garcia-Gonzalo, Francesc R., Corbit, Kevin C., Sirerol-Piquer, María Salomé, Ramaswami, Gokul, Otto, Edgar A., Noriega, Thomas R., Seol, Allen D., Robinson, Jon F., Bennett, Christopher L., Josifova, Dragana J., García-Verdugo, José Manuel, Katsanis, Nicholas, Hildebrandt, Friedhelm, Reiter, Jeremy F.“…Cell types that do not require Tctn1 for ciliogenesis require it to localize select membrane-associated proteins to the cilium, including Arl13b, AC3, Smoothened and Pkd2. Tctn1 forms a complex with multiple ciliopathy proteins associated with Meckel (MKS) and Joubert (JBTS) syndromes, including Mks1, Tmem216, Tmem67, Cep290, B9d1, Tctn2, and Cc2d2a. …”
Publicado 2011
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656por Cheng, Yu-Ching, O’Connell, Jeffrey R., Cole, John W., Stine, O. Colin, Dueker, Nicole, McArdle, Patrick F., Sparks, Mary J., Shen, Jess, Laurie, Cathy C., Nelson, Sarah, Doheny, Kimberly F., Ling, Hua, Pugh, Elizabeth W., Brott, Thomas G., Brown, Robert D., Meschia, James F., Nalls, Michael, Rich, Stephen S., Worrall, Bradford, Anderson, Christopher D., Biffi, Alessandro, Cortellini, Lynelle, Furie, Karen L., Rost, Natalia S., Rosand, Jonathan, Manolio, Teri A., Kittner, Steven J., Mitchell, Braxton D.“…Although no single SNP reached genome-wide significance (P < 5 × 10(−8)), we identified two SNPs in chromosome 2q23.3, rs2304556 (in FMNL2; P = 1.2 × 10(−7)) and rs1986743 (in ARL6IP6; P = 2.7 × 10(−7)), strongly associated with early-onset stroke. …”
Publicado 2011
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657por Xing, Dong-Jun, Zhang, Hong-Xing, Huang, Na, Wu, Kun-Chao, Huang, Xiu-Feng, Huang, Fang, Tong, Yi, Pang, Chi-Pui, Qu, Jia, Jin, Zi-Bing“…Six pathological mutations, including five novel mutations, were revealed in the genes BBS2, MKKS, ARL6, MKS1. This study represents the first report of targeted exome sequencing in BBS patients and demonstrates that high-throughput TES is an accurate and rapid method for the genetic diagnosis of BBS.…”
Publicado 2014
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658“…In contrast to MCs, irradiation attenuated the extracellular ATP content of neurons, which could be abolished by ARL 67156, a nonspecific ecto-ATPases inhibitor. …”
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659“…We obtained significant results using small GTPase Arl2 as a test subject protein. We propose peptide nanoparticle-mediated antibody transfection to be a superior alternative to antibody microinjection for preliminary functional studies of unknown proteins in mouse oocytes.…”
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660“…This analysis identified a role for Arl1 in stabilizing the Mon2/Dop1 complex and uncovered a new function for Vps13 in early endosome recycling and Neo1 localization. …”
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