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  1. 661
    “…To establish the mechanism of action of calcimycin, which is known to stimulate activity of mammalian constitutive nitric oxide synthase (NOS), we coincubated L. major promastigotes with calcimycin and selective NOS inhibitors ARL-17477 or L-NNA. Addition of these inhibitors substantially decreased the toxicity of calcimycin to Leishmania promastigotes. …”
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    Calcium Ionophore, Calcimycin, Kills Leishmania Promastigotes by Activating Parasite Nitric Oxide Synthase
  2. 662
    “…Intriguingly, RNA-seq analysis suggests that both compounds inhibit other virulence-regulatory systems such as Agr, ArlRS, and SarA more efficiently than they inhibit the Sae system. …”
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    The FDA-approved anti-cancer drugs, streptozotocin and floxuridine, reduce the virulence of Staphylococcus aureus
  3. 663
    por Jeschke, Andreas, Haas, Albert
    Publicado 2018
    “…Moreover, our data indicate that PI(4)P is needed to anchor Arl8 (Arf-like GTPase 8) and its effector homotypic fusion/vacuole protein sorting complex (HOPS) to (phago)lysosome membranes, whereas PI(3)P is required for membrane association of HOPS only. …”
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    Sequential actions of phosphatidylinositol phosphates regulate phagosome-lysosome fusion
  4. 664
    “…Here we report Chickspress (http://geneatlas.arl.arizona.edu), the first publicly available gene expression resource for chicken tissues. …”
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    Chickspress: a resource for chicken gene expression
  5. 665
    “…Proteins involved in inflammation (fibrinogen alpha (FIBA), serotransferrin (TRFE, and kininogen-1 (KNG1)) and insulin resistance (ADP-ribosylation factor (ARF)-like protein 15 (ARL15) and retinol-binding protein 4 (RET4)) were found to be significantly increased in the urine samples of MUHO compared to MHO patients. …”
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    A Proteomics-Based Approach Reveals Differential Regulation of Urine Proteins between Metabolically Healthy and Unhealthy Obese Patients
  6. 666
    “…We also showed that the identified Arl4d pRE could drive sufficient expression of channelrhodopsin for optogenetic rescue of behavioral deficits in the Dlx5/6(+/−) mouse model of fast-spiking CIN dysfunction.…”
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    Regulatory Elements Inserted into AAVs Confer Preferential Activity in Cortical Interneurons
  7. 667
    “…P4 MSCs exhibited reductions in the frequency and length of primary cilia associated with decreased intensity of Arl13b staining on cilia. Senescence also resulted in downregulation of the expression of hedgehog components and CDKN2A. …”
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    Primary Cilia as a Biomarker in Mesenchymal Stem Cells Senescence: Influencing Osteoblastic Differentiation Potency Associated with Hedgehog Signaling Regulation
  8. 668
    “…The nNOS expression in cM1 was negatively correlated with improved recovery. nNOS inhibitor (ARL 17477)-treated stroke mice exhibited a significant functional improvement in speed at post-stroke day 10, when compared to stroke mice receiving vehicle (saline) only. …”
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    Optogenetic Stimulation Reduces Neuronal Nitric Oxide Synthase Expression After Stroke
  9. 669
    “…SARS-CoV-2 ORF3a facilitates lysosomal targeting of the BORC-ARL8b complex, which mediates trafficking of lysosomes to the vicinity of the plasma membrane, and exocytosis-related SNARE proteins. …”
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    ORF3a of SARS-CoV-2 promotes lysosomal exocytosis-mediated viral egress
  10. 670
    “…Genes related to resistance found in all genomes included norA (fluoroquinolone), arlRS (fluoroquinolone), lmrS (multidrug), tet(38) (tetracycline) and mepAR (multidrug and tigecycline resistance). …”
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    Shared antibiotic resistance and virulence genes in Staphylococcus aureus from diverse animal hosts
  11. 671
    “…In archaea, the adaptor protein CheF resides at the cytoplasmic face of the archaeal C-ring formed by the proteins ArlCDE and interacts with phosphorylated CheY. While the mechanism of CheY binding to the C-ring is well-studied in bacteria, the role of CheF in archaea remains enigmatic and mechanistic insights are absent. …”
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    Structural insights into the mechanism of archaellar rotational switching
  12. 672
    “…Immunofluorescence analysis on skin fibroblasts on one of the four cases with the antibody for ARL13B that decorates primary cilia revealed shorter primary cilia that are consistent with a ciliary defect. …”
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    Biallelic variants in CENPF causing a phenotype distinct from Strømme syndrome
  13. 673
    “…Due to the lack of a conserved, short ciliary localization motif, the full-length ARL13b or 5HT(6) proteins are normally used for cilia labelling. …”
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    A transgenic zebrafish for in vivo visualization of cilia
  14. 674
    “…Interestingly, HOOK1 staining suggests that the perinuclear ring is established; however, ARL3 staining is disrupted, suggesting that lack of PFN4 does not interfere with the formation of the perinuclear ring and initial localization of HOOK1, but impedes microtubular organization of the manchette. …”
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    PFN4 is required for manchette development and acrosome biogenesis during mouse spermiogenesis
  15. 675
    “…JWA, also known as ADP ribosylation factor-like GTPase 6 interacting protein 5 (ARL6IP5, GenBank: AF070523, 1998), is a microtubule-associated protein and an environmental response gene. …”
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    Targeting JWA for Cancer Therapy: Functions, Mechanisms and Drug Discovery
  16. 676
    “…We show that inner medullary collecting duct-3 cells expressing the TULP3 R382W patient variant have a severely reduced ability to localize the membrane-associated proteins ARL13b, INPP5E, and GPR161 to the cilium, consistent with a loss of TULP3 function. …”
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    A pathogenic variant of TULP3 causes renal and hepatic fibrocystic disease
  17. 677
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    Progress in the Preclinical Discovery and Clinical Development of Class I and Dual Class I/IV Phosphoinositide 3-Kinase (PI3K) Inhibitors
  18. 678
    “…In support of integrated pest management practices, machine learning algorithms were proposed as tools to forecast aerobiological risk level (ARL) of Phytophthora infestans (>10 sporangia/m(3)) as inoculum to new infections. …”
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    Predicting Daily Aerobiological Risk Level of Potato Late Blight Using C5.0 and Random Forest Algorithms under Field Conditions
  19. 679
    “…Combination of MRCS syndrome and extremely long axial length was evidently diagnosed in both eyes, with XFS confirmed in her right eye, but mutation screening failed to identify disease-causing sequence variants in some specific genes reported previously, including BEST1 and ARL2. However, likely pathogenic mutations in FBN2 gene were identified. …”
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    Coexistence of MRCS syndrome, extremely long axis and exfoliation syndrome: a case report and literature review
  20. 680
    “…The effectiveness of the proposed AEWMA control chart is evaluated through the average run length (ARL) and standard deviation of run length (SDRL). …”
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    Adaptive EWMA control chart using Bayesian approach under ranked set sampling schemes with application to Hard Bake process
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