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  1. 701
    “…A compound heterozygous mutation in the gene usherin 2A (USH2A; c.6,485+5G>A/c.11,156G>A) and a heterozygous X-linked mutation in the gene retinitis pigmentosa 2 (RP2) ARL3 GTPase-activating protein (RP2; c.358C>T) were identified by Sanger sequencing and co-segregation analysis, of which the pathogenic mutation (c.6,485+5G>A) in USH2A has not been previously reported among Chinese patients. …”
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    Compound pathogenic mutation in the USH2A gene in Chinese RP families detected by whole-exome sequencing
  2. 702
    “…However, other fusions detected simultaneously in normal and tumour samples (JAK3-INSL3, KANSL1-ARL17A/B and TFG-ADGRG7) could be germ-line fusions genes involved in tumour-maintaining tasks. …”
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    Detection of novel fusion-transcripts by RNA-Seq in T-cell lymphoblastic lymphoma
  3. 703
    “…Since ATP is processed in extracellular space to adenosine by ectonucleotidases including cell surface expressed CD39 and CD73, we asked if inhibition of these enzymes by employing in vivo small molecular inhibitors ARL67156 and AMPCP of CD39 and CD73 respectively, alone or combined could enhance granulocyte stimulating factor (G-CSF)- and AMD3100-induced pharmacological mobilization of stem cells. …”
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    The Inhibition of CD39 and CD73 Cell Surface Ectonucleotidases by Small Molecular Inhibitors Enhances the Mobilization of Bone Marrow Residing Stem Cells by Decreasing the Extracellular Level of Adenosine
  4. 704
    “…[Image: see text] The trafficking chaperone PDE6D (also referred to as PDEδ) has been nominated as a surrogate target for K-Ras4B (hereafter K-Ras). Arl2-assisted unloading of K-Ras from PDE6D in the perinuclear area is significant for correct K-Ras localization and therefore activity. …”
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    PDE6D Inhibitors with a New Design Principle Selectively Block K-Ras Activity
  5. 705
    “…Novel deleterious variants in IDH3B and ARL6 were identified, supporting their involvement in RD. …”
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    Extensive genic and allelic heterogeneity underlying inherited retinal dystrophies in Mexican patients molecularly analyzed by next‐generation sequencing
  6. 706
    “…This interaction provides a potential mechanism for targeting Rheb to membranes that contain Arl2, a small GTPase that triggers the release of prenylated proteins from PDEδ. …”
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    Coordination of Rheb lysosomal membrane interactions with mTORC1 activation
  7. 707
    “…Amitriptyline interfered with the fusion of autophagosome and lysosome through the activation of PI3K/Akt/mTOR pathway and Beclin 1 acetylation, and regulated lysosome positioning by increasing the interaction between proteins Arl8, SKIP, and kinesin. To the best of our knowledge, we are the first to demonstrate that amitriptyline interferes with autophagic flux by regulating the autophagosome maturation during autophagy in neuronal cells. …”
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    Amitriptyline interferes with autophagy-mediated clearance of protein aggregates via inhibiting autophagosome maturation in neuronal cells
  8. 708
    “…Additionally, preventing eATP hydrolysis by pre-injection of ARL67156, a non-specific inhibitor of ecto-ATPases, led to the increase in eATP levels and the abolishment of AP analgesic effect. (4) Conclusions: These observations indicate that needling-induced transient accumulation of eATP, due to the activation of mechanosensitive TRPV4 channels and the activities of ecto-ATPases, is involved in the trigger mechanism of AP analgesia.…”
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    Mechanosensitive TRPV4 Channel-Induced Extracellular ATP Accumulation at the Acupoint Mediates Acupuncture Analgesia of Ankle Arthritis in Rats
  9. 709
    “…Surprisingly, the inhibitory effects of TTFields and TMZ on tumor cell recurrence are linked to the relative timing of TMZ exposure to TTFields and ARL13B(+) cilia. Finally, TTFields disrupted cilia in patient tumors treated ex vivo. …”
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    Tumor Treating Fields Suppression of Ciliogenesis Enhances Temozolomide Toxicity
  10. 710
    “…Furthermore, nine key prognostic genes, namely, HOXC8, SRPX, CCL22, CD72, IGLON5, SERPING1, PCOLCE2, FABP4, and ARL4C, were identified using the LASSO Cox regression analysis. …”
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    A Systematic Framework for Identifying Prognostic Genes in the Tumor Microenvironment of Colon Cancer
  11. 711
    “…Formalin‐fixed paraffin‐embedded cutaneous resections were processed for immunohistochemistry or immunostaining with the following primary antibodies: mouse anti‐MCM6, rabbit anti‐ARL13B and rabbit anti‐GLI1. RESULTS: BCC recurrence after free margin excision was significantly linked to a higher proliferative index (p < 0.001) and a lower cilia count (p = 0.041) in the primary lesion. …”
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    Preliminary results on a proposed histopathological assessment of predictive factors for basal cell carcinoma recurrence after primary free margin excision
  12. 712
    “…It accounts for only 2% of all acquired immune deficiency syndrome (AIDS)-related lymphomas (ARLs). We present the case of a 45-year-old male who presented to the emergency department (ED) with a three-month history of abdominal pain, diarrhea, and unintentional 50-lb weight loss. …”
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    Plasmablastic Lymphoma Presenting With Rectosigmoid Perforation in a Human Immunodeficiency Virus-Positive Patient
  13. 713
    “…CONCLUSIONS: CX3CR1, SLC7A5, ARL4C, TLR7, and MTHFD2 might be used as novel biomarkers to improve the accuracy of KOA disease diagnosis, monitor disease progression, and improve the efficacy of clinical treatment.…”
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    Cross-Tissue Analysis Using Machine Learning to Identify Novel Biomarkers for Knee Osteoarthritis
  14. 714
    “…Lineage‐specific innovations include protrudin, Caspr1, Arl6IP1, p180, NogoR, kinectin and CLIMP‐63, which are restricted to the Opisthokonta. …”
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    Evolution of factors shaping the endoplasmic reticulum
  15. 715
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    Summary and Conclusions of the 'JRA Beam Telescope 2025'-Forum at the 6th Beam Telescopes and Test Beams Workshop
  16. 716
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    Primary Extradural Tumors of the Spine – Case Review with Evidence-guided Management
  17. 717
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    A Statewide Model for Assisting Nursing Home Residents to Transition Successfully to the Community
  18. 718
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    Residential Water Meters as Edge Computing Nodes: Disaggregating End Uses and Creating Actionable Information at the Edge
  19. 719
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    International Evidence on the COVID-19 Deaths of People Who Live in Long-Term Care Facilities
  20. 720
    “…Nine loci were genomewide significant in the EA meta-analysis: 5 novel loci (reproductive subtype); 2 loci (metabolic subtype), including c9orf3; 2 loci (background subtype), including FSHB/ARL14P. Five of 6 other lead SNPs in the original analysis remained nominally significant. …”
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    OR20-02 Trans-Ethnic Analysis Of PCOS Subtype Genomewide Association Signals Reveals 3 Shared Subtype-Specific Loci
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