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861“…Although the majority of associations were breed specific, associations that operated across breeds included SORCS1 on BTA26, MCTP2 on BTA21 and ARL15 on BTA20; these are of particular interest due to their potential informativeness in across-breed genomic evaluations. …”
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862por Fabbri, Lucilla, Dufies, Maeva, Lacas-Gervais, Sandra, Gardie, Betty, Gad-Lapiteau, Sophie, Parola, Julien, Nottet, Nicolas, Meyenberg Cunha de Padua, Monique, Contenti, Julie, Borchiellini, Delphine, Ferrero, Jean-Marc, Leclercq, Nathalie Rioux, Ambrosetti, Damien, Mograbi, Baharia, Richard, Stéphane, Viotti, Julien, Chamorey, Emmanuel, Sadaghianloo, Nirvana, Rouleau, Matthieu, Craigen, William J., Mari, Bernard, Clavel, Stéphan, Pagès, Gilles, Pouysségur, Jacques, Bost, Frédéric, Mazure, Nathalie M.“…Ciliogenesis was detected using both mouse anti-acetylated α-tubulin and rabbit polyclonal ARL13B antibodies for immunofluorescence. Results: Our study defines, for the first time, a group of ccRCC patients in which the hypoxia-cleaved form of VDAC1 (VDAC1-ΔC) induces resorption of the primary cilium in a Hypoxia-Inducible Factor-1 (HIF-1)-dependent manner. …”
Publicado 2020
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863por Almacellas, Eugènia, Pelletier, Joffrey, Day, Charles, Ambrosio, Santiago, Tauler, Albert, Mauvezin, Caroline“…Abbreviations: 3D: three-dimensional; APC/C: anaphase-promoting complex; ARL8B: ADP ribosylation factor like GTPase 8B; ATG: autophagy-related; BORC: BLOC-one-related complex; CDK: cyclin-dependent kinase; CENPE: centromere protein E; CIN: chromosomal instability; ConcA: concanamycin A; CQ: chloroquine; DAPI: 4,6-diamidino-2-penylinole; FTI: farnesyltransferase inhibitors; GFP: green fluorescent protein; H2B: histone 2B; KIF: kinesin family member; LAMP2: lysosomal associated membrane protein 2; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MEF: mouse embryonic fibroblast; MTOR: mechanistic target of rapamycin kinase; PDS5B: PDS5 cohesin associated factor B; SAC: spindle assembly checkpoint; PLEKHM2: pleckstrin homology and RUN domain containing M2; SQSTM1: sequestosome 1; TEM: transmission electron microscopy; ULK1: unc-51 like autophagy activating kinase 1; UPS: ubiquitin-proteasome system; v-ATPase: vacuolar-type H(+)-translocating ATPase; WAPL: WAPL cohesion release factor.…”
Publicado 2020
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864por Shi, Ping, Hoang-Minh, Lan B., Tian, Jia, Cheng, Alice, Basrai, Reemsha, Kalaria, Neil, Lebowitz, Joseph J., Khoshbouei, Habibeh, Deleyrolle, Loic P., Sarkisian, Matthew R.“…To test whether the antiproliferative effects of HDAC6 inhibitors are dependent on tumor cell cilia, we generated patient-derived glioma lines devoid of cilia through depletion of ciliogenesis genes ARL13B or KIF3A. At low concentrations, 1215 or 738 did not decrease the proliferation of cilia-depleted cells. …”
Publicado 2021
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865por Kumar, Prashant, Zadjali, Fahad, Yao, Ying, Siroky, Brian, Astrinidis, Aristotelis, Gross, Kenneth W., Bissler, John J.“…Immunoblotting detected cilial Hedgehog signaling protein Arl13b; intercellular proteins TSG101 and Alix; and transmembrane proteins CD63, CD9, and CD81. …”
Publicado 2021
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866por Ramirez, Karla, Fernández, Rosa, Collet, Sarah, Kiyar, Meltem, Delgado-Zayas, Enrique, Gómez-Gil, Esther, Van Den Eynde, Tibbert, T’Sjoen, Guy, Guillamon, Antonio, Mueller, Sven C., Pásaro, Eduardo“…The most significant CpGs were related to genes: WDR45B, SLC6A20, NHLH1, PLEKHA5, UBALD1, SLC37A1, ARL6IP1, GRASP, and NCOA6. Regarding the female assigned at birth populations, we found 2 CpGs that passed both criteria (FDR p < 0.05; fold change ≥ ± 2), but none were located in islands. …”
Publicado 2021
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867por Sheng, Taotao, Ho, Shamaine Wei Ting, Ooi, Wen Fong, Xu, Chang, Xing, Manjie, Padmanabhan, Nisha, Huang, Kie Kyon, Ma, Lijia, Ray, Mohana, Guo, Yu Amanda, Sim, Ngak Leng, Anene-Nzelu, Chukwuemeka George, Chang, Mei Mei, Razavi-Mohseni, Milad, Beer, Michael A., Foo, Roger Sik Yin, Sundar, Raghav, Chan, Yiong Huak, Tan, Angie Lay Keng, Ong, Xuewen, Skanderup, Anders Jacobsen, White, Kevin P., Jha, Sudhakar, Tan, Patrick“…We identified cancer-relevant genes (ING1, ARL4C) whose expression between patients is influenced by enhancer differences in genomic copy number and germline SNPs, and HNF4α as a master trans-acting factor associated with GC enhancer heterogeneity. …”
Publicado 2021
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868“…RNAseq analysis of these fish revealed that hundreds of protein-encoding genes with important diverse biological functions such as arsenic metabolism (as3mt), cell migration (arl4ab), immune system activity (ptgr1), actin cytoskeletal remodelling (wdr1), corticogenesis (dgcr2), protein dephosphorylation (ublcp1), sialic acid metabolism (st6galnac3) and ketone body metabolism (aacs) were differentially expressed between HAZ and LAZ, suggesting a strong genetic contribution to this phenotype. …”
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869por Ong, Chong Hui Clara, Lee, Dong Yeul, Lee, Bernett, Li, Huihua, Lim, Jeffrey Chun Tatt, Lim, Johnathan Xiande, Yeong, Joe Poh Sheng, Lau, Hiu Yeung, Thike, Aye Aye, Tan, Puay Hoon, Iqbal, Jabed“…Gene ontology enrichment analysis revealed six significantly enriched cellular functions (secretion, cellular component disassembly, regulation of protein complex assembly, glycolytic process, cellular macromolecular complex assembly, positive regulation of cellular component biogenesis) associated with genes differentially expressed (CAIX, SETX, WAS, HK2, DDIT4, TUBA4α, ARL1). Three genes (WAS, SETX and DDIT4) were related to DNA repair, indicating that DNA stability may be influenced by hypoxia in TNBC. …”
Publicado 2022
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870“…METHODS: Male 38-week-old C57BL/6J mice were divided into five groups (n = 8/group): control (CON), Low-dose AR-treated (ARL, 100 mg/kg/day), High-dose AR-treated (ARH, 200 mg/kg/day), exercise (EXC), and EXC + ARH (EXH) group. …”
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871por Aresta Branco, Mafalda S. L., Gutierrez Cruz, Alejandro, Dayton, Jacob, Perrino, Brian A., Mutafova-Yambolieva, Violeta N.“…The common nucleotidase inhibitors ARL67156, POM-1, PSB06126, and ENPP1 Inhibitor C, but not the alkaline phosphatase inhibitor (-)-p-bromotetramisole oxalate, inhibited the enzymes released during bladder distention. …”
Publicado 2022
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872por Sharma, Ritika, Frasch, Martin G., Zelgert, Camila, Zimmermann, Peter, Fabre, Bibiana, Wilson, Rory, Waldenberger, Melanie, MacDonald, James W., Bammler, Theo K., Lobmaier, Silvia M., Antonelli, Marta C.“…In addition, two differentiated methylation regions (DMR) related to maternal stress measures PDQ and cortisol were found: DAXX and ARL4D. CONCLUSIONS: Genes annotated to these CpGs were found to be involved in secretion and transportation, nuclear signaling, Hippo signaling pathways, apoptosis, intracellular trafficking and neuronal signaling. …”
Publicado 2022
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873por Akarsu, Hatice, Liljander, Anne, Younan, Mario, Brodard, Isabelle, Overesch, Gudrun, Glücks, Ilona, Labroussaa, Fabien, Kuhnert, Peter, Perreten, Vincent, Monecke, Stefan, Drexler, Jan Felix, Corman, Victor Max, Falquet, Laurent, Jores, Joerg“…They were resistant to at least one of the following antimicrobials: tetracycline, benzylpenicillin, oxacillin, erythromycin, clindamycin, trimethoprim, gentamicin, or streptomycin, encoded by tet(K), blaZ/bla(ARL), mecA/mecA1, msrA/mphC, salA, dfrG, aacA-aphD, and str, respectively. …”
Publicado 2022
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874“…The computed particle transport trajectories, combined with the online Proton Transfer Reaction-Mass Spectrometry (PTR-MS) data (https://figshare.com/articles/dataset/ARL_Data_from_PROS_station_at_Hanford_site/19993964), can be used to identify and quantify the sources and affected area of the hazardous chemicals’ emission using the potential source distribution function (PSDF). …”
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875por Blue, Andrew, Affolder, Tony, Ai, Xiaocong, Allport, Phillip, Arling, Jan-Hendrik, Atkin, Ryan Justin, Bruni, Lucrezia Stella, Carli, Ina, Casse, Gianluigi, Chen, Liejian, Chisholm, Andrew, Cormier, Kyle James Read, Cunningham, William Reilly, Dervan, Paul, Diez Cornell, Sergio, Dolezal, Zdenek, Dopke, Jens, Dreyer, Etienne, Dreyling-Eschweiler, Jan Linus Roderik, Escobar, Carlos, Fabiani, Veronica, Fadeyev, Vitaliy, Fernandez Tejero, Javier, Fleta Corral, Maria Celeste, Gallop, Bruce, Garcia-Argos, Carlos, Greenall, Ashley, Gregor, Ingrid-Maria, Greig, Graham George, Guescini, Francesco, Hara, Kazuhiko, Hauser, Marc Manuel, Huang, Yanping, Hunter, Robert Francis Holub, Keller, John, Klein, Christoph, Kodys, Peter, Koffas, Thomas, Kotek, Zdenek, Kroll, Jiri, Kuehn, Susanne, Lee, Steven Juhyung, Liu, Yi, Lohwasser, Kristin, Meszarosova, Lucia, Mikestikova, Marcela, Mi\~nano Moya, Mercedes, Mori, Riccardo, Moser, Brian, Nikolopoulos, Konstantinos, Peschke, Richard, Pezzullo, Giuseppe, Phillips, Peter William, Poley, Anne-luise, Queitsch-Maitland, Michaela, Ravotti, Federico, Rodriguez Rodriguez, Daniel, Rossi, Edoardo, Rummler, Andr{e}, Sawyer, Craig, Sperlich, Dennis, Sullivan, Stephanie W, Suzuki, Junki, Sykora, Martin, Tahirovic, Elvedin, Theiner, Ondrej, Thomas, Juergen, Unno, Yoshinobu, Wada, Sayaka, Warren, Matthew, Wiehe, Moritz Oliver, Wonsak, Sven, Wormald, Michael, Wraight, Kenneth, Zakharchuk, Nataliia, Zhu, HongboEnlace del recurso
Publicado 2018
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876“…The genes WASL, ENPP5, ARL6IP1, and IDH1 showed the most significant and strongest downregulation after hsa-miR-142-3p, -17-5p, -223-3p, and -30e-5p transfection, respectively. …”
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877por Zhou, Chenghao, Li, Cong, Cai, Wentao, Liu, Shuli, Yin, Hongwei, Shi, Shaolei, Zhang, Qin, Zhang, Shengli“…Taken together with previously reported quantitative trait loci and the biological functions of the identified genes, we propose 19 novel candidate genes affecting milk protein composition traits: ARL6, SST, EHHADH, PCDHB4, PCDHB6, PCDHB7, PCDHB16, SLC36A2, GALNT14, FPGS, LARP4B, IDI1, COG4, FUK, WDR62, CLIP3, SLC25A21, IL5RA, and ACADSB. …”
Publicado 2019
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880“…CYP19A1 'aromatase' (rs2899472), NCAM2, and multiple SNPs located on chromosome 10 near the ARL5B gene demonstrated the strongest associations with Aβ(1-42 )in normal subjects. …”
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