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Mostrando 101 - 120 Resultados de 1,286 Para Buscar '"Arles"', tiempo de consulta: 0.33s Limitar resultados
  1. 101
    “…Here we show, in two different human breast adenocarcinoma models, that Arl2 content has a major impact on breast tumor cell aggressivity both in vitro and in vivo. …”
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    ADP Ribosylation Factor Like 2 (Arl2) Regulates Breast Tumor Aggressivity in Immunodeficient Mice
  2. 102
    “…The small ciliary G protein Arl13b is required for cilium biogenesis and sonic hedgehog signaling and is mutated in patients with Joubert syndrome (JS). …”
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    Joubert syndrome Arl13b functions at ciliary membranes and stabilizes protein transport in Caenorhabditis elegans
  3. 103
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    Joubert syndrome Arl13b functions at ciliary membranes and stabilizes protein transport in Caenorhabditis elegans
  4. 104
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    The HIV nef protein within ARL is genetically and structurally distinct from those in the brain of patients with HAD
  5. 105
    “…We used this library with the protein complementation assay to identify two novel binding partners for ras-related ADP-ribosylation factor-like 11 (ARL11), cellular retinoic acid binding protein 2 (CRABP2), and phosphoglycerate mutase 1 (PGAM1). …”
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    In-Frame cDNA Library Combined with Protein Complementation Assay Identifies ARL11-Binding Partners
  6. 106
    “…Homotypic fusion and vacuole protein sorting (HOPS) complex members were identified as effectors of Arl8b and were dependent on Arl8b for recruitment to lysosomes, suggesting that Arl8b-HOPS plays a general role in directing traffic to lysosomes. …”
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    Lysosomal Trafficking, Antigen Presentation, and Microbial Killing Are Controlled by the Arf-like GTPase Arl8b
  7. 107
    “…Arl13b modulates ciliary signaling necessary for radial glial polarity. …”
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    Arl13b-regulated activities of primary cilia are essential for the formation of the polarized radial glial scaffold
  8. 108
    “…No additional putative causal variants in ARL3 were identified in the follow-up cohort, suggesting that if ARL3 variants can cause adRP it is an extremely rare phenomenon.…”
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    De Novo Occurrence of a Variant in ARL3 and Apparent Autosomal Dominant Transmission of Retinitis Pigmentosa
  9. 109
    “…PURPOSE: Mutations in the gene ARL13B cause the classical form of Joubert syndrome, an autosomal recessive ciliopathy with variable degrees of retinal degeneration. …”
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    Arl13b Interacts With Vangl2 to Regulate Cilia and Photoreceptor Outer Segment Length in Zebrafish
  10. 110
    por Al-Bassam, Jawdat
    Publicado 2017
    “…Here I describe a revised model for the function of three tubulin cofactors and Arl2 as a multisubunit GTP-hydrolyzing catalytic chaperone that cycles to promote αβ-tubulin biogenesis and degradation. …”
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    Revisiting the tubulin cofactors and Arl2 in the regulation of soluble αβ-tubulin pools and their effect on microtubule dynamics
  11. 111
    “…Small GTPases, such as Rab7 and Arl8b, recruit their downstream effectors to mediate this transport and fusion. …”
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    The Rab7 effector PLEKHM1 binds Arl8b to promote cargo traffic to lysosomes
  12. 112
    “…Here, we identify a novel upstream control mechanism of Arl8b-dependent lysosomal movement toward the periphery of the cell. …”
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    LAMTOR/Ragulator is a negative regulator of Arl8b- and BORC-dependent late endosomal positioning
  13. 113
    “…The small GTPase Arl8 has emerged as a major regulatory GTPase on lysosomes. …”
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    The small G protein Arl8 contributes to lysosomal function and long-range axonal transport in Drosophila
  14. 114
    “…CONCLUSIONS: Our report shows that the phenotype associated with ARL6IP1 variants may be broader and more acute than so far reported and identifies fatal HSP as the severe end of the phenotypic spectrum of ARL6IP1 variants.…”
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    Truncating ARL6IP1 variant as the genetic cause of fatal complicated hereditary spastic paraplegia
  15. 115
    “…We investigated the role of the ADP-ribosylation factor (Arf)-like (Arl) protein Arl13b in breast cancer cell migration and invasion in vitro, using breast cancer cell lines and in vivo, using mouse orthotopic models. …”
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    Arl13b Regulates Breast Cancer Cell Migration and Invasion by Controlling Integrin-Mediated Signaling
  16. 116
    “…The small GTPase Arl13b is enriched in primary cilia and regulates Sonic hedgehog (Shh) signaling. …”
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    The Ciliary Protein Arl13b Functions Outside of the Primary Cilium in Shh-Mediated Axon Guidance
  17. 117
    “…ADP-ribosylation factor-like 4aa (Arl4aa) is a member of the ADP-ribosylation factor family. …”
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    Function of Arl4aa in the Initiation of Hematopoiesis in Zebrafish by Maintaining Golgi Complex Integrity in Hemogenic Endothelium
  18. 118
    “…The binding of Arl8b with its effector, SKIP, is increased after radiation through regulation of BORC-subunits. …”
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    Lysosomal trafficking mediated by Arl8b and BORC promotes invasion of cancer cells that survive radiation
  19. 119
    “…This interaction is dependent on the C-terminal EB homology region of EB1 and partially dependent on an SxLP motif of Arl4D. We found that Arl4D colocalized with γ-tubulin in centrosomes and the depletion of Arl4D resulted in a centrosomal MT nucleation defect. …”
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    Arl4D-EB1 interaction promotes centrosomal recruitment of EB1 and microtubule growth
  20. 120
    “…Emerging evidence suggests that ADP-ribosylation factor like-4c (Arl4c) may be a potential choice for cancer treatment. …”
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    Arl4c promotes the growth and drug resistance of pancreatic cancer by regulating tumor-stromal interactions
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