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  1. 76921
    “…Evaluated by five-fold cross-validation on the training set, PSLNuc attains an overall accuracy of 79.7%, which is 4.8% improvement over the state-of-the-art system. In addition, our method also enhances the MCC from 0.497 to 0.595. …”
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    Prediction of nuclear proteins using nuclear translocation signals proposed by probabilistic latent semantic indexing
  2. 76922
    “…Such conjunctive-disjunctive language of cluster definitions enables finding real-world outbreaks that are often missed by other state-of-art algorithms like What’s Strange About Recent Events (WSARE) [3] or Large Average Submatrix (LAS) [2]. …”
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    Searching for Complex Patterns Using Disjunctive Anomaly Detection
  3. 76923
    “…We focus on predicting the performance of the C-family of algorithms, because they are widely used, state-of-art outbreak detection algorithms [2]. We investigate the influence of algorithm characteristics and outbreak characteristics in determining outbreak detection performance. …”
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    Determinants of Outbreak Detection Performance
  4. 76924
    “…The volume and complexity of such data leads to significant challenges in terms of its analysis, especially when one seeks to generate hypotheses or explore the underlying biological processes. At the state-of-the-art, the application of automated algorithms followed by perusal and analysis of the results by an expert continues to be the predominant paradigm for analyzing biological data. …”
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    Towards human-computer synergetic analysis of large-scale biological data
  5. 76925
    “…CONCLUSION: This analysis demonstrated that in all five partners state-of-the-art preventative mental healthcare was included in the last deployment in Afghanistan, including a positive approach towards strengthening the mental resilience, a focus on self-regulatory skills and self-empowerment, and several initiatives that were well-integrated in a military context. …”
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    Deployment-related mental health support: comparative analysis of NATO and allied ISAF partners
  6. 76926
    “…Being on ARV treatment significantly reduced the risk of developing an STD (IRR 0.37, 95% CI 0.32–0.43) compared to ART-naïve people, even in the situation of temporary interruption of treatment (IRR 0.51, 95% CI 0.39–0.43) (see Figure 1). …”
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    Increased incidence of sexually transmitted diseases in the recent years: data from the ICONA cohort
  7. 76927
    “…RESULTS: A total of 413 patients [77% males, median age 46 (IQR 39–52), 17% with past AIDS-defining events, 19% past IDU, 3% with diabetes, 94% on cART, 90% with HIV RNA <50 copies/mL, 18% co-infected with HCV] were enrolled. …”
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    Liver fibrosis is associated with cognitive impairment in HIV-positive patients
  8. 76928
    “…INTRODUCTION: We report interim 24-weeks efficacy data of ATLAS-M trial, a phase IV, multicentre, open-label, randomized study designed to show 48-weeks, non-inferior efficacy (margin of −12%) of treatment simplification to atazanavir/ritonavir (ATV/r)+lamivudine (3TC) versus maintaining 3-drugs ATV/r-based cART. METHODS: Subjects on ATV/r+2 NRTIs, without previous treatment failure (TF), with HIV-RNA <50copies/mL for >3 months and CD4>200 cells/mm(3) for >6 months were eligible. …”
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    Simplification to atazanavir/ritonavir+lamivudine in virologically suppressed HIV-infected patients: 24-weeks interim analysis from ATLAS-M trial
  9. 76929
    “…Like elsewhere in Africa, there is no routine viral load testing, making it difficult to get sensitive analysis of data on ART efficacy within routine clinical practice. Nevertheless, this observational study is reassuring in terms of efficacy of both ATV/r and LPV/r for patients failing first line therapy in our setting.…”
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    Boosted lopinavir vs boosted atazanavir in patients failing a NNRTI first line regimen in an urban clinic in Kampala
  10. 76930
    “…CONCLUSIONS: The initial results from GUSTA study show that ART-regimen including MVC did not increase the incidence of adverse events or severe laboratory liver abnormalities in HIV-1-infected patients with or without HCV coinfection. …”
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    Safety and therapeutic efficacy of the switch to maraviroc+darunavir/ritonavir in HIV/HCV coinfected patients: initial results from GUSTA study
  11. 76931
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    Defining the fitness of HIV-1 isolates with dual/mixed co-receptor usage
  12. 76932
    “…Treatment planning employed a Monte Carlo dose calculation in SmART-Plan and creation of 0.5cm thick lead blocks custom-shaped to match DRR projections. …”
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    Treatment Planning and Delivery of Whole Brain Irradiation with Hippocampal Avoidance in Rats
  13. 76933
    por Almeida, Beverley, Campanilho‐Marques, Raquel, Arnold, Katie, Pilkington, Clarissa A., Wedderburn, Lucy R., Nistala, Kiran, Armon, Kate, Briggs, Vanja, Ellis‐Gage, Joe, Roper, Holly, Watts, Joanna, Baildam, Eileen, Hanna, Louise, Lloyd, Olivia, McCann, Liza, Roberts, Ian, McGovern, Ann, Riley, Phil, Al‐Abadi, Eslam, Ryder, Clive, Scott, Janis, Southwood, Taunton, Thomas, Beverley, Amin, Tania, Burton, Deborah, Jackson, Gillian, Van Rooyen, Vanessa, Wood, Mark, Wyatt, Sue, Browne, Michael, Davidson, Joyce, Ferguson, Sue, Gardner‐Medwin, Janet, Martin, Neil, Waxman, Liz, Foster, Helen, Friswell, Mark, Jandial, Sharmila, Qiao, Lisa, Sen, Ethan, Smith, Eve, Stevenson, Vicky, Swift, Alison, Wade, Debbie, Watson, Stuart, Crate, Lindsay, Frost, Anna, Jordan, Mary, Mosley, Ellen, Satyapal, Rangaraj, Stretton, Elizabeth, Venning, Helen, Warrier, Kishore, Almeida, Beverley, Arnold, Katie, Beard, Laura, Brown, Virginia, Campanilho‐Marques, Raquel, Enayat, Elli, Glackin, Yvonne, Halkon, Elizabeth, Hasson, Nathan, Juggins, Audrey, Kassoumeri, Laura, Lunt, Sian, Maillard, Sue, Nistala, Kiran, Pilkington, Clarissa, Simou, Stephanie, Smith, Sally, Varsani, Hemlata, Wedderburn, Lucy, Murray, Kevin, Ioannou, John, Suffield, Linda, Al‐Obaidi, Muthana, Leach, Sam, Lee, Helen, Smith, Helen, Inness, Emma, Kendall, Eunice, Mayers, David, Wilkinson, Nick, Clinch, Jacqui, Pluess‐Hall, Helen
    Publicado 2015
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    Analysis of Published Criteria for Clinically Inactive Disease in a Large Juvenile Dermatomyositis Cohort Shows That Skin Disease Is Underestimated
  14. 76934
    “…CONCLUSIONS: Treatment durability is dependent on several factors among others patient characteristics and ART guidelines. The choice of 3(rd) agent has a strong impact and significant differences between different drugs on treatment duration exist.…”
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    HIV drug therapy duration; a Swedish real world nationwide cohort study on InfCareHIV 2009-2014
  15. 76935
    “…BACKGROUND: Depression, highly prevalent in HIV, is consistently associated with worse ART adherence. Integrating CBT for depression with adherence counseling using the “Life-Steps” approach (CBT-AD) has an emerging evidence base. …”
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    Treating Depression and Adherence (CBT-AD) in Patients with HIV in Care: A Three-arm Randomized Controlled Trial
  16. 76936
    “…To examine the performance, comparison tests between the proposed RSBF and six state-of-the-art methods for ultrasound speckle removal are performed on simulated ultrasound images with various noise and speckle levels. …”
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    Rayleigh-maximum-likelihood bilateral filter for ultrasound image enhancement
  17. 76937
    “…Despite robot-led physical training could potentially improve the motor recovery of hemiparetic patients, most of the state-of-the-art studies addressing motor control learning, with artificial virtual force fields, only focused on the end-effector kinematic adaptation, by using planar devices. …”
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    Modifying upper-limb inter-joint coordination in healthy subjects by training with a robotic exoskeleton
  18. 76938
    “…METHODS: Matched plasma DBS and DPS were obtained from 200 HIV-1 infected antiretroviral treatment (ART)-experienced patients attending patient support centers in Western Kenya. …”
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    Evaluation of the performance of Abbott m2000 and Roche COBAS Ampliprep/COBAS Taqman assays for HIV-1 viral load determination using dried blood spots and dried plasma spots in Kenya
  19. 76939
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    Systems biology driving drug development: from design to the clinical testing of the anti-ErbB3 antibody seribantumab (MM-121)
  20. 76940
    “…Plans were created using the TomoTherapy TPS for delivery using the Hi·Art system, the iPlan TPS for delivery using the Vero system, the Eclipse TPS for delivery using the TrueBeam system in both flattened and flattening filter free (FFF), and the MultiPlan TPS for delivery using the CyberKnife system. …”
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    Single‐fraction spine SBRT end‐to‐end testing on TomoTherapy, Vero, TrueBeam, and CyberKnife treatment platforms using a novel anthropomorphic phantom
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