“…It is well established that axonal microtubules (MTs) are uniformly oriented with their plus ends distal to the neuronal cell body (Heidemann, S. …”
Enlace del recurso
Enlace del recurso

“…Previous work from our laboratory suggested that microtubules are released from the neuronal centrosome and then transported into the axon (Ahmad, F.J., and P.W. Baas. 1995. J. Cell Sci. 108: 2761–2769). …”
Enlace del recurso
Enlace del recurso

“…We have investigated the axonal transport of neurofilament protein in cultured neurons by constricting single axons with fine glass fibers. …”
Enlace del recurso
Enlace del recurso

“…In squid, frog, rat, and human nerves examined in thin sections with the electron microscope the axon contains, in addition to certain other particulates, characteristic filaments. …”
Enlace del recurso
Enlace del recurso

“…Leg muscles of the monkey have been studied following partial denervation produced by surgical elimination of from 25 to 90 per cent of the axons entering the sciatic nerve from the lumbosacral plexus. …”
Enlace del recurso
Enlace del recurso

“…In the present work, we used the Wld(s) mutant mouse, a strain in which axonal degeneration is considerably slowed down, to show that axon to myelin traffic takes place in the absence of axon degeneration. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Alternating current impedance measurements have been made over a wide frequency range on the giant axon from the stellar nerve of the squid, Loligo pealii, during the passage of a nerve impulse. …”
Enlace del recurso
Enlace del recurso

“…The action of a number of agents, which may be classified as "stabilizers" and "unstabilizers" on the electrical oscillations and after-potentials in the squid giant axon has been examined. The effects on the spike, "positive overshoot," and "potassium potential" were also observed, but where possible concentrations were employed which left these phenomena unaltered. …”
Enlace del recurso
Enlace del recurso

“…A technique is described for recording the bioelectric activity of the squid giant axon during and following alteration of the internal axonal composition with respect to ions or other substances. 2. …”
Enlace del recurso
Enlace del recurso

“…Behavior of this kind indicates that central axons carry a well developed L fraction of membrane properties. …”
Enlace del recurso
Enlace del recurso

“…Loss of Klc function results in progressive lethargy, crawling defects, and paralysis followed by death at the end of the second larval instar. Klc mutant axons contain large aggregates of membranous organelles in segmental nerve axons. …”
Enlace del recurso
Enlace del recurso

“…Neurons transmit long-range biochemical signals between cell bodies and distant axonal sites or termini. To test the hypothesis that signaling molecules are hitchhikers on axonal vesicles, we focused on the c-Jun NH(2)-terminal kinase (JNK) scaffolding protein Sunday Driver (syd), which has been proposed to link the molecular motor protein kinesin-1 to axonal vesicles. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Recent studies have shown that the transport of microtubules (MTs) and neurofilaments (NFs) within the axon is rapid, infrequent, asynchronous, and bidirectional. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

Enlace del recurso
Enlace del recurso

“…Neuronal polarity is, at least in part, mediated by the differential sorting of membrane proteins to distinct domains, such as axons and somata/dendrites. We investigated the pathways underlying the subcellular targeting of NgCAM, a cell adhesion molecule residing on the axonal plasma membrane. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Neurofilaments are transported through axons by slow axonal transport. Abnormal accumulations of neurofilaments are seen in several neurodegenerative diseases, and this suggests that neurofilament transport is defective. …”
Enlace del recurso
Enlace del recurso

“…The differences between such a normal axon and the usual isolated axon can be accounted for by a negligible leakage conductance in the normal axon.…”
Enlace del recurso
Enlace del recurso

“…The potential differences across the squid giant axon membrane, as measured with a series of microcapillary electrodes filled with concentrations of KCl from 0.03 to 3.0 M or sea water, are consistent with a constant membrane potential and the liquid junction potentials calculated by the Henderson equation. …”
Enlace del recurso
Enlace del recurso

“…The concepts, experiments, and interpretations of ionic current measurements after a step change of the squid axon membrane potential require the potential to be constant for the duration and the membrane area measured. …”
Enlace del recurso
Enlace del recurso

“…The membrane current density, I(m), in the squid giant axon has been calculated from the measured external current applied to the axon, I(o), by the equation See PDF for Equation where V(m) is the membrane potential under the current electrode and r(1) and r(2) are the external and internal longitudinal resistances. …”
Enlace del recurso
Enlace del recurso