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641“…Axonal homeostasis is maintained by processes that include cytoskeletal regulation, cargo transport, synaptic activity, ionic balance, and energy supply. …”
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642“…The axonal cytoskeleton is organized in a highly periodic structure, the membrane-associated periodic skeleton (MPS), which is essential to maintain the structure and function of the axon. …”
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643por Eichel, Kelsie, Uenaka, Takeshi, Belapurkar, Vivek, Lu, Rui, Cheng, Shouqiang, Pak, Joseph S., Taylor, Caitlin A., Südhof, Thomas C., Malenka, Robert, Wernig, Marius, Özkan, Engin, Perrais, David, Shen, Kang“…Neurons are highly polarized cells that face the fundamental challenge of compartmentalizing a vast and diverse repertoire of proteins in order to function properly(1). The axon initial segment (AIS) is a specialized domain that separates a neuron’s morphologically, biochemically and functionally distinct axon and dendrite compartments(2,3). …”
Publicado 2022
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644“…Axons are considered to be particularly vulnerable components of the nervous system; impairments to a neuron’s axon leads to an effective silencing of a neuron’s ability to communicate with other cells. …”
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645por Chen, Hung-Ju, Tani, Jowy, Lin, Cindy Shin-Yi, Chang, Tsui-San, Lin, Yi-Chen, Hsu, Ting-Wei, Sung, Jia-Ying“…OBJECTIVE: This study investigated how peripheral axonal excitability changes in ischemic stroke patients with hemiparesis or hemiplegia, reflecting the plasticity of motor axons due to corticospinal tract alterations along the poststroke stage. …”
Publicado 2022
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646por Dumrongprechachan, Vasin, Salisbury, Ryan B, Butler, Lindsey, MacDonald, Matthew L, Kozorovitskiy, Yevgenia“…Mammalian axonal development begins in embryonic stages and continues postnatally. …”
Publicado 2022
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647por Pauli, Jordan L, Chen, Jane Y, Basiri, Marcus L, Park, Sekun, Carter, Matthew E, Sanz, Elisenda, McKnight, G Stanley, Stuber, Garret D, Palmiter, Richard D“…We also provide detailed visualization of the axonal projections from 21 Cre-driver lines of mice. …”
Publicado 2022
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648por Stirling, David P.“…Clinical disability following trauma or disease to the spinal cord often involves the loss of vital white matter elements including axons and glia. Although excessive Ca(2+) is an established driver of axonal degeneration, therapeutically targeting externally sourced Ca(2+) to date has had limited success in both basic and clinical studies. …”
Publicado 2022
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649por Ktena, Niki, Kaplanis, Stefanos Ioannis, Kolotuev, Irina, Georgilis, Alexandros, Kallergi, Emmanouela, Stavroulaki, Vasiliki, Nikoletopoulou, Vassiliki, Savvaki, Maria, Karagogeos, Domna“…Significant morphological defects in myelin membrane such as decompaction accompanied with increased axonal degeneration are observed. As a result, the mice exhibit behavioral deficits. …”
Publicado 2022
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650por Buchanan, JoAnn, Elabbady, Leila, Collman, Forrest, Jorstad, Nikolas L., Bakken, Trygve E., Ott, Carolyn, Glatzer, Jenna, Bleckert, Adam A., Bodor, Agnes L., Brittain, Derrick, Bumbarger, Daniel J., Mahalingam, Gayathri, Seshamani, Sharmishtaa, Schneider-Mizell, Casey, Takeno, Marc M., Torres, Russel, Yin, Wenjing, Hodge, Rebecca D., Castro, Manuel, Dorkenwald, Sven, Ih, Dodam, Jordan, Chris S., Kemnitz, Nico, Lee, Kisuk, Lu, Ran, Macrina, Thomas, Mu, Shang, Popovych, Sergiy, Silversmith, William M., Tartavull, Ignacio, Turner, Nicholas L., Wilson, Alyssa M., Wong, William, Wu, Jingpeng, Zlateski, Aleksandar, Zung, Jonathan, Lippincott-Schwartz, Jennifer, Lein, Ed S., Seung, H. Sebastian, Bergles, Dwight E., Reid, R. Clay, da Costa, Nuno Maçarico“…Unexpectedly, we discovered that the fine processes of oligodendrocyte precursor cells (OPCs), a population of abundant, highly dynamic glial progenitors, frequently surrounded small branches of axons. Numerous phagosomes and phagolysosomes (PLs) containing fragments of axons and vesicular structures were present inside their processes, suggesting that OPCs engage in axon pruning. …”
Publicado 2022
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651“…Most importantly, tau null mice have deficits in axonal outgrowth and neuronal migration while still possessing an extensive microtubule network. …”
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652por Tomàs, Josep, Lanuza, Maria A., Santafé, Manel M., Cilleros-Mañé, Víctor, Just-Borràs, Laia, Balanyà-Segura, Marta, Polishchuk, Aleksandra, Nadal, Laura, Tomàs, Marta, Garcia, Neus“…Moreover, mAChRs allow direct activity-dependent interaction through ACh release between the multiple competing axons during development. Additional regulation from pre- and postsynaptic sites (including neurotrophic retrograde control), the agonistic and antagonistic contributions of adenosine receptors (AR; A(1) and A(2A)), and the tropomyosin-related kinase B receptor (TrkB) cooperate with mAChRs in the axonal competitive interactions which lead to supernumerary synapse elimination that achieves the optimized monoinnervation of musculoskeletal cells. …”
Publicado 2022
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653“…Using three release site baits, we identified proteins that are enriched over the general dopamine axonal protein content, and they fell into several categories, including active zone, Ca(2+) regulatory, and synaptic vesicle proteins. …”
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654“…Further, the AcD configuration had an influence on BC axonal development. Axons originating from an AcD formed denser arborizations with more terminal endings within the dendritic field of the parent cell. …”
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655Publicado 1985“…MAP2 immunoreactivity was present in axons of spinal motor neurons, but was not detected in axons of white matter tracts of spinal cord and in the majority of axons of the dorsal root. …”
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656por Rao, Mala V., Houseweart, Megan K., Williamson, Toni L., Crawford, Thomas O., Folmer, Janet, Cleveland, Don W.“…Neurofilaments are essential for establishment and maintenance of axonal diameter of large myelinated axons, a property that determines the velocity of electrical signal conduction. …”
Publicado 1998
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657Publicado 1996“…Neurofascin and NrCAM are two axon-associated transmembrane glycoproteins belonging to the L1 subgroup of the Ig superfamily. …”
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658por Wolman, Marc A, Sittaramane, Vinoth K, Essner, Jeffrey J, Yost, H Joseph, Chandrasekhar, Anand, Halloran, Mary C“…Using in vivo time-lapse imaging, we show that both positive axon-axon interactions and guidance by surrounding tissue control initial nucMLF axon guidance. …”
Publicado 2008
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659por Ko, Hyo Rim, Kwon, Il-Sun, Hwang, Inwoo, Jin, Eun-Ju, Shin, Joo-Ho, Brennan-Minnella, Angela M, Swanson, Raymond, Cho, Sung-Woo, Lee, Kyung-Hoon, Ahn, Jee-Yin“…Mechanistic studies of axon growth during development are beneficial to the search for neuron-intrinsic regulators of axon regeneration. …”
Publicado 2016
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660por Erdogan, Burcu, Cammarata, Garrett M., Lee, Eric J., Pratt, Benjamin C., Francl, Andrew F., Rutherford, Erin L., Lowery, Laura Anne“…BACKGROUND: Formation of precise neuronal connections requires proper axon guidance. Microtubules (MTs) of the growth cone provide a critical driving force during navigation of the growing ends of axons. …”
Publicado 2017
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