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  1. 141
    “…Axonal regeneration after injury requires the coordinated expression of genes in injured neurons. …”
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    Genetic Deletion of the Transcriptional Repressor NFIL3 Enhances Axon Growth In Vitro but Not Axonal Repair In Vivo
  2. 142
    por Ribas, Vinicius T., Lingor, Paul
    Publicado 2016
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    Calcium channel inhibition-mediated axonal stabilization improves axonal regeneration after optic nerve crush
  3. 143
    “…We found that the anterior–posterior coarse targeting of OSN axons is disrupted after OSN axon injury, while the local axon sorting mechanisms remained. …”
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    Distorted Coarse Axon Targeting and Reduced Dendrite Connectivity Underlie Dysosmia after Olfactory Axon Injury
  4. 144
    “…The inhibitory environment of the spinal cord and the intrinsic properties of neurons prevent regeneration of axons following CNS injury. However, both ascending and descending axons of the injured spinal cord have been shown to regenerate into grafts of embryonic neural progenitor cells (NPCs). …”
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    Neural Progenitor Cells Promote Axonal Growth and Alter Axonal mRNA Localization in Adult Neurons
  5. 145
    “…Diffuse axonal injury (DAI) is the most common and significant pathological features of traumatic brain injury (TBI). …”
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    Protection of FK506 against neuronal apoptosis and axonal injury following experimental diffuse axonal injury
  6. 146
    “…Deletion of the axonal transport element reduced TH mRNA levels in the distal axons and reduced the axonal protein levels of TH and TH activity as measured by phosphorylation of SER40 in SCG neurons. …”
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    Disruption of the Axonal Trafficking of Tyrosine Hydroxylase mRNA Impairs Catecholamine Biosynthesis in the Axons of Sympathetic Neurons
  7. 147
    “…JAM2). However, axons still present long unmyelinated segments proposed to contribute to axonal plasticity and higher order brain functions. …”
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    Neurons define non-myelinated axon segments by the regulation of galectin-4-containing axon membrane domains
  8. 148
    “…BACKGROUND: Netrin-1, a multifunctional axon guidance cue, elicits axon outgrowth via one of its receptors deleted in colorectal cancer (DCC) in several types of neurons, including cerebral cortical neurons of embryonic mice. …”
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    Shift in the function of netrin-1 from axon outgrowth to axon branching in developing cerebral cortical neurons
  9. 149
    “…In cortical, long-range projecting, pyramidal neurons (PNs), dendritic mitochondria are long and tubular whereas axonal mitochondria display uniformly short length. …”
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    MFF-dependent mitochondrial fission regulates presynaptic release and axon branching by limiting axonal mitochondria size
  10. 150
    por Dun, Xin-Peng, Parkinson, David B.
    Publicado 2019
    “…Currently, the major clinical challenge for peripheral nerve repair come from long gaps between the proximal and distal nerve stumps, which prevent regenerating axons reaching the distal nerve. Precise axon targeting during nervous system development is controlled by families of axon guidance molecules including Netrins, Slits, Ephrins and Semaphorins. …”
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    Classic axon guidance molecules control correct nerve bridge tissue formation and precise axon regeneration
  11. 151
    “…Axonal protein synthesis has been shown to play a role in developmental and regenerative growth, as well as in the maintenance of the axoplasm in a steady state. …”
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    Axon microdissection and transcriptome profiling reveals the in vivo RNA content of fully differentiated myelinated motor axons
  12. 152
    “…In contrast, less is known about the role of TDP-43 in axonal RNA metabolism in motoneurons. Here we show that depletion of Tdp-43 in primary motoneurons affects axon growth. …”
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    Loss of Tdp-43 disrupts the axonal transcriptome of motoneurons accompanied by impaired axonal translation and mitochondria function
  13. 153
    “…We demonstrate that adult PNS neurons utilise two catalytic subunits of PI3K for axon regeneration: p110α and p110δ. However, in the CNS, axonal PIP (3) decreases with development at the time when axon transport declines and regenerative competence is lost. …”
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    PI 3‐kinase delta enhances axonal PIP (3) to support axon regeneration in the adult CNS
  14. 154
    por Costa, Ana Rita, Sousa, Monica M.
    Publicado 2020
    “…Their dynamic nature is essential for neuronal biology including the establishment of polarity, growth cone formation and motility, axon growth during development (and axon regeneration in the adult), radial and longitudinal axonal tension, and synapse formation and function. …”
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    Non-Muscle Myosin II in Axonal Cell Biology: From the Growth Cone to the Axon Initial Segment
  15. 155
    “…In Drosophila tok mutants lacking Slit cleavage, midline repulsion of axons occurs normally, confirming that Slit-FL is sufficient to repel axons. …”
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    Proteolytic cleavage of Slit by the Tolkin protease converts an axon repulsion cue to an axon growth cue in vivo
  16. 156
    “…After optic nerve crush (ONC), the cell bodies and distal axons of most retinal ganglion cells (RGCs) degenerate. …”
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    Coupled Control of Distal Axon Integrity and Somal Responses to Axonal Damage by the Palmitoyl Acyltransferase ZDHHC17
  17. 157
    “…In neurons, the axon and axon initial segment (AIS) are critical structures for action potential initiation and propagation. …”
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    A sticky situation: regulation and function of protein palmitoylation with a spotlight on the axon and axon initial segment
  18. 158
    “…INTRODUCTION: Chronic inflammatory demyelinating polyneuropathy (CIDP) may have a similar clinical and electrophysiological presentation to non-inflammatory axonal polyneuropathies (NIAPs) when secondary axonal damage occurs. …”
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    Nerve Ultrasound Distinguishes Non-Inflammatory Axonal Polyneuropathy From Inflammatory Polyneuropathy With Secondary Axonal Damage
  19. 159
    “…Axonally synthesized proteins support nerve regeneration through retrograde signaling and local growth mechanisms. …”
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    Intra-axonal translation of Khsrp mRNA slows axon regeneration by destabilizing localized mRNAs
  20. 160
    “…Sensory axons appear to be responsible for neural feedback from cutaneous mechanoreceptors to control the movement of facial muscles and the tongue. …”
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    Axonal mapping of the motor cranial nerves
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