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19821por Morton, Aaron B., Norton, Charles E., Jacobsen, Nicole L., Fernando, Charmain A., Cornelison, D. D. W., Segal, Steven S.“…Eliminating Ca(2+) from PSS prevented the rise in [Ca(2+)](i) and ameliorated myonuclear staining with PI during BaCl(2) exposure. Motor axons and capillary networks appeared fragmented within 24 h following injection of 1.2% BaCl(2) and morphological integrity deteriorated through 72 h. …”
Publicado 2019
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19822“…We recorded field excitatory postsynaptic potentials (fEPSP) in the CA1’s stratum radiatum by stimulation of the CA3 Schaeffer collateral/commissural axons. Uridine was applied at concentrations (3, 30, 300 μM) representing the physiological range present in brain tissue. …”
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19823“…When downregulated in cortical neurons in vitro, leads to shorter axons with less branching. Female mice with LKB1 removed from their peripheral sensory neurons have litters more often and increased litter sizes compared to wild-type mice, which led to the investigation into the mechanisms into the role of LKB1 in sensory neurons in ovarian function. …”
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19824por Deng, Wu-Sheng, Ma, Ke, Liang, Bing, Liu, Xiao-Yin, Xu, Hui-You, Zhang, Jian, Shi, Heng-Yuan, Sun, Hong-Tao, Chen, Xu-Yi, Zhang, Sai“…Collagen scaffolds can not only provide support and guidance for axonal regeneration, but can also serve as a bridge for nerve regeneration at the injury site. …”
Publicado 2020
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19825por Gonzales, Mitzi M., Short, Meghan I., Satizabal, Claudia L., O’ Bryant, Sid, Tracy, Russel P., Zare, Habil, Seshadri, Sudha“…DISCUSSION: Blood biomarkers of neuronal/axonal and glial injury differentiated between clinical diagnostic groups in a bi‐ethnic cohort of Hispanic and non‐Hispanic Whites. …”
Publicado 2021
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19826por Oliveira-Filho, Antonio Fernandes, Medeiros, Paula F V, Velloso, Renata N, Lima, Erika C S, Aquino, Ivna M, Nunes, Adriana Bezerra“…Besides, ENMG confirmed last year peripheral motor sensitive polyneuropathy, axonal pattern, distal both lower extremities. The patient failed treatment with modifications in diet and hygiene, but achieved symptomatic improvement after metronidazole. …”
Publicado 2021
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19827por Román, Gustavo C., Gracia, Fernando, Torres, Antonio, Palacios, Alexis, Gracia, Karla, Harris, Diógenes“…Three ATM patients also had blindness from myeloneuritis optica (MNO) and two more also had acute motor axonal neuropathy (AMAN). CONCLUSIONS: We found ATM to be an unexpectedly frequent neurological complication of COVID-19. …”
Publicado 2021
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19828por Kira, Jun-ichi“…The neuropathology of biopsied sural nerve shows Schwann cell terminal loop detachment from axons without macrophage infiltration or inflammation. …”
Publicado 2021
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19829por Dehdashtian, Amir, Svientek, Shelby R., Ursu, Daniel C., Kung, Theodore A., Cederna, Paul S., Kemp, Stephen WP“…The Regenerative Peripheral Nerve Interface (RPNI) was developed as a stable biologic interface on the notion of providing physiologic end-organ targets for regenerating axons by implantation of a residual nerve into an autogenous free muscle graft. …”
Publicado 2021
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19830por Adiutori, Rocco, Puentes, Fabiola, Bremang, Michael, Lombardi, Vittoria, Zubiri, Irene, Leoni, Emanuela, Aarum, Johan, Sheer, Denise, McArthur, Simon, Pike, Ian, Malaspina, Andrea“…Circulating protein aggregates are enriched with neurofilament heavy chain—axonal proteins involved in brain aggregate formation and recently identified as biomarkers of the fatal neuromuscular disorder amyotrophic lateral sclerosis. …”
Publicado 2021
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19831“…BACKGROUND: The DYNC1H1 gene encodes a part of the dynamic protein, and the protein mutations may further affect the growth and development of neurons, resulting in degeneration of anterior horn cells of the spinal cord, and a variety of clinical phenotypes finally resulting in axonal Charcot-Marie-Tooth disease type 20 (CMT20), mental retardation 13 (MRD13) and spinal muscular atrophy with lower extremity predominant 1 (SMA-LED). …”
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19832por Souza, Flávia dos Santos, Freitas, Nicole Lardini, Gomes, Yago Côrtes Pinheiro, Torres, Rafael Carvalho, Echevarria-Lima, Juliana, da Silva-Filho, Isaac Lima, Leite, Ana Claudia Celestino Bezerra, de Lima, Marco Antonio Sales Dantas, da Silva, Marcus Tulius Teixeira, Araújo, Abelardo de Queiroz Campos, Espíndola, Otávio Melo“…Human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a neurodegenerative disease due to axonal damage of the corticospinal secondary to an inflammatory response against infected T-cells. …”
Publicado 2021
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19833por Khundadze, Mukhran, Ribaudo, Federico, Hussain, Adeela, Stahlberg, Henry, Brocke-Ahmadinejad, Nahal, Franzka, Patricia, Varga, Rita-Eva, Zarkovic, Milena, Pungsrinont, Thanakorn, Kokal, Miriam, Ganley, Ian G., Beetz, Christian, Sylvester, Marc, Hübner, Christian A.“…Hereditary spastic paraplegia (HSP) denotes genetically heterogeneous disorders characterized by leg spasticity due to degeneration of corticospinal axons. SPG11 and SPG15 have a similar clinical course and together are the most prevalent autosomal recessive HSP entity. …”
Publicado 2021
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19834por Datta, Dibyadyuti, Bangirana, Paul, Opoka, Robert O., Conroy, Andrea L., Co, Katrina, Bond, Caitlin, Zhao, Yi, Kawata, Keisuke, Saykin, Andrew J., John, Chandy C.“…CONCLUSIONS AND RELEVANCE: In this study, plasma tau, a marker of injury to neuronal axons, was elevated in children with CM or SMA and was associated with mortality and persistent NCI in children with CM younger than 5 years.…”
Publicado 2021
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19835por Salvadó, Gemma, Shekari, Mahnaz, Falcon, Carles, Operto, Grégory, Milà-Alomà, Marta, Sánchez-Benavides, Gonzalo, Cacciaglia, Raffaele, Arenaza-Urquijo, Eider, Niñerola-Baizán, Aida, Perissinotti, Andrés, Minguillon, Carolina, Fauria, Karine, Kollmorgen, Gwendlyn, Suridjan, Ivonne, Molinuevo, José Luis, Zetterberg, Henrik, Blennow, Kaj, Suárez-Calvet, Marc, Gispert, Juan Domingo“…We included 319 cognitively unimpaired participants from the ALFA+ cohort with available structural MRI, fluorodeoxyglucose PET and CSF biomarkers of amyloid-β and tau pathology (phosphorylated tau and total tau), synaptic dysfunction (neurogranin), neuronal and axonal injury (neurofilament light), glial activation (soluble triggering receptor on myeloid cells 2, YKL40, GFAP, interleukin-6 and S100b) and α-synuclein using the Roche NeuroToolKit. …”
Publicado 2022
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19836por Brummer, Tobias, Muthuraman, Muthuraman, Steffen, Falk, Uphaus, Timo, Minch, Lena, Person, Maren, Zipp, Frauke, Groppa, Sergiu, Bittner, Stefan, Fleischer, Vinzenz“…Taken together, early neuro-axonal loss reflects worse information processing speed, the key deficit underlying cognitive dysfunction in multiple sclerosis. …”
Publicado 2022
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19837“…A nerve conduction study showed moderate left peroneal motor axonal neuropathy, with normal sensory nerve action potentials. …”
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19838“…Hurst (10) observed that poliomyelitis virus, after injection into the left sciatic nerve, may, after invading the lumbar cord, be found first in the contralateral motor cortex or thalamus and he suggested that this was evidence of progression along a decussating pathway and in favor of the axonal hypothesis of virus spread. It was not shown, however, that this particular localization was specifically related to the introduction of virus in the left sciatic nerve, or that it could be reversed by inoculating the sciatic nerve of the opposite side. …”
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19839por El Achkoura, Jihad, El Mahil, Doaa, Kyal, Nada, Lmidmani, Fatima, El Fatimi, Abdellatif“…Un ENMG a mis en évidence une polyradiculonévrite sensitivo-motrice aiguë de mécanisme axonal à prédominance motrice et aux membres inférieurs avec une dissociation albumino-cytologique à la ponction lombaire. …”
Publicado 2023
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19840por Appeltshauser, Luise, Junghof, Helena, Messinger, Julia, Linke, Janis, Haarmann, Axel, Ayzenberg, Ilya, Baka, Panoraia, Dorst, Johannes, Fisse, Anna L, Grüter, Thomas, Hauschildt, Valerie, Jörk, Alexander, Leypoldt, Frank, Mäurer, Mathias, Meinl, Edgar, Michels, Sebastian, Motte, Jeremias, Pitarokoili, Kalliopi, Stettner, Mark, Villmann, Carmen, Weihrauch, Marc, Welte, Gabriel S, Zerr, Inga, Heinze, Katrin G, Sommer, Claudia, Doppler, Kathrin“…As a possible correlate of axonal damage in vivo, we detected highly increased serum neurofilament light chain levels (sNF-L), correlating to serum C3a. …”
Publicado 2022
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