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19881por Zhang, Qunzhou, Burrell, Justin C., Zeng, Jincheng, Motiwala, Faizan I., Shi, Shihong, Cullen, D. Kacy, Le, Anh D.“…In addition, our results indicate that implantation of functionalized nerve protectors repopulated with GiSCs significantly accelerated functional recovery and axonal regeneration of crush-injured rat sciatic nerves accompanied by increased infiltration of pro-regenerative (M2) macrophages while a decreased infiltration of pro-inflammatory (M1) macrophages. …”
Publicado 2022
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19882por Wesenhagen, Kirsten E. J., Tijms, Betty M., Boonkamp, Lynn, Hoede, Patty L., Goossens, Julie, Dewit, Nele, Scheltens, Philip, Vanmechelen, Eugeen, Visser, Pieter Jelle, Teunissen, Charlotte E.“…Therefore, in the current study, we further investigated which potential processes may be related with p-tau subgroups, by comparing individuals on CSF markers for presynaptic structure [vesicle-associated membrane protein 2 (VAMP2)], postsynaptic structure [neurogranin (NRGN)], axonal damage [neurofilament light (NfL)], and amyloid production [beta-secretase 1 (BACE1) and amyloid-beta 1–40 (Aβ40)]. …”
Publicado 2022
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19883por Zhao, Yongfang, Mu, Hongfeng, Huang, Yichen, Li, Sicheng, Wang, Yangfan, Stetler, R. Anne, Bennett, Michael V. L., Dixon, C. Edward, Chen, Jun, Shi, Yejie“…TBI-induced injury to axons and myelin was ameliorated, and signal conduction by white matter fiber tracts was significantly enhanced in HDAC3 miKO mice. …”
Publicado 2022
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19884por Yeo, Tianrong, Bayuangga, Halwan, Augusto-Oliveira, Marcus, Sealey, Megan, Claridge, Timothy D. W., Tanner, Rachel, Leppert, David, Palace, Jacqueline, Kuhle, Jens, Probert, Fay, Anthony, Daniel C.“…Neither serum nor CSF NfL levels correlated with markers of neuroinflammation; serum NfL did, however, correlate strongly with axonal loss (r = 0.641, p = 0.001), but CSF NfL did not (p = 0.137). …”
Publicado 2022
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19885por Lapucci, Caterina, Tazza, Francesco, Rebella, Silvia, Boffa, Giacomo, Sbragia, Elvira, Bruschi, Nicolò, Mancuso, Elisabetta, Mavilio, Nicola, Signori, Alessio, Roccatagliata, Luca, Cellerino, Maria, Schiavi, Simona, Inglese, Matilde“…If in MS, inflammation, primitive demyelination and axonal loss coexist, in SVD demyelination is secondary to ischemic microangiopathy, while the contemporary presence of inflammatory and ischemic processes has been suggested in migraine. …”
Publicado 2023
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19886por Lopez, Ivan A, Acuna, Dora, Beltran-Parrazal, Luis, Lopez, Ivan E, Amarnani, Abhimanyu, Cortes, Max, Edmond, John“…These changes correlate with reductions of proteins important to cerebellar function: pre-synaptic terminals proteins (synapsin-1), proteins for the maintenance of neuronal size, shape and axonal quality (neurofilaments) and protein involved in GABAergic neurotransmission (GAD). …”
Publicado 2009
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19887por Ha, Yonju, Saul, Alan, Tawfik, Amany, Zorrilla, Eric P., Ganapathy, Vadivel, Smith, Sylvia B.“…Recently we analyzed the retinal phenotype of mice lacking σR1 (σR1 KO) and observed normal retinal morphology and function in young mice (5–30 weeks) but diminished negative scotopic threshold responses (nSTRs), retinal ganglion cell (RGC) loss, and disruption of optic nerve axons consistent with inner retinal dysfunction by 1 year. …”
Publicado 2012
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19888por Farkas, Imre, Vastagh, Csaba, Farkas, Erzsébet, Bálint, Flóra, Skrapits, Katalin, Hrabovszky, Erik, Fekete, Csaba, Liposits, Zsolt“…Furthermore, GLP-1 immunoreactive (IR) axons innervated GnRH neurons in the hypothalamus suggesting that GLP-1 of both peripheral and neuronal sources can modulate GnRH neurons. …”
Publicado 2016
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19889por Karmacharya, S., Gagoski, B., Ning, L., Vyas, R., Cheng, H.H., Soul, J., Newberger, J.W., Shenton, M.E., Rathi, Y., Grant, P.E.“…Further, we used two novel measures from a non-parametric GMM, namely the Return-to-Origin Probability (RTOP) and Return-to-Axis Probability (RTAP), which are sensitive to axonal/cellular volume and density respectively. Using atlas-based registration, 22 white matter regions (6 projection, 4 association, and 1 callosal pathways bilaterally in each hemisphere) were selected and the mean value of all 7 measures were calculated in each region. …”
Publicado 2018
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19890por Janzen, Eva, Mendoza-Ferreira, Natalia, Hosseinibarkooie, Seyyedmohsen, Schneider, Svenja, Hupperich, Kristina, Tschanz, Theresa, Grysko, Vanessa, Riessland, Markus, Hammerschmidt, Matthias, Rigo, Frank, Bennett, C Frank, Kye, Min Jeong, Torres-Benito, Laura, Wirth, Brunhilde“…Congruently, CHP1 downregulation restored impaired axonal growth in Smn-depleted NSC34 motor neuron-like cells, SMA zebrafish and primary murine SMA motor neurons. …”
Publicado 2018
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19891por Calvi, Alberto, Tur, Carmen, Chard, Declan, Stutters, Jonathan, Ciccarelli, Olga, Cortese, Rosa, Battaglini, Marco, Pietroboni, Anna, De Riz, Milena, Galimberti, Daniela, Scarpini, Elio, De Stefano, Nicola, Prados, Ferran, Barkhof, Frederik“…T1-hypointense black holes, and reductions in magnetization transfer ratio (MTR) are pathologically correlated with myelin and axonal loss. While all associated with progressive MS, the relationship between these lesion’s metrics and clinical outcomes in relapse-onset MS has not been widely investigated. …”
Publicado 2022
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19892por Hejazian, Leila Beigom, Akbarnejad, Zeinab, Moghani Ghoroghi, Fatemeh, Esmaeilzade, Banafshe, Chaibakhsh, Samira“…CONCLUSION: The achieved results propose that hair follicle stem cells improve axonal growth and functional recovery after peripheral nerve injury. …”
Publicado 2022
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19893por Ferrer, Isidro, Andrés-Benito, Pol, Zelaya, Maria Victoria, Aguirre, Maria Elena Erro, Carmona, Margarita, Ausín, Karina, Lachén-Montes, Mercedes, Fernández-Irigoyen, Joaquín, Santamaría, Enrique, del Rio, José Antonio“…Expression of oligodendrocyte markers OLIG1 and OLIG2mRNA, and myelin-related genes MBP, PLP1, CNP, MAG, MAL, MOG, and MOBP are significantly decreased in WM; CNPase, PLP1, and MBP antibodies reveal reduction and disruption of myelinated fibres; and SMI31 antibodies mark axonal damage in the WM. Altered expression of AQ4, GLUC-t, and GLT-1 is also observed in sGGT and in GGT linked to MAPT K317M mutation. …”
Publicado 2020
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19894por Morgenstern, Jakob, Groener, Jan B., Jende, Johann M. E., Kurz, Felix T., Strom, Alexander, Göpfert, Jens, Kender, Zoltan, Le Marois, Maxime, Brune, Maik, Kuner, Rohini, Herzig, Stephan, Roden, Michael, Ziegler, Dan, Bendszus, Martin, Szendroedi, Julia, Nawroth, Peter, Kopf, Stefan, Fleming, Thomas“…CONCLUSIONS/INTERPRETATION: This study introduces a dynamic and non-invasive assessment strategy for the underlying pathogenesis of diabetic peripheral neuropathy. The diagnosis of axonal degeneration, associated with hyperalgesia, and demyelination, linked to hypoalgesia, could benefit from the usage of neurofilament light chain protein and circulating mRNA of myelin protein zero as potential biomarkers. …”
Publicado 2021
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19895por Farid, Mariam F., Abouelela, Yara S., Yasin, Noha A. E., Al-Mokaddem, Asmaa K., Prince, Abdelbary, Ibrahim, Marwa A., Rizk, Hamdy“…Based on our results, the SVF co-treated group revealed remyelination and regeneration capacity with a reduction in apoptosis and axonal degeneration. CONCLUSION: SVF is considered an easy, valuable, and promising therapeutic approach for treating spinal cord injuries, particularly MS. …”
Publicado 2023
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19896por Tran, Kristine M., Kawauchi, Shimako, Kramár, Enikö A., Rezaie, Narges, Liang, Heidi Yahan, Sakr, Jasmine S., Gomez-Arboledas, Angela, Arreola, Miguel A., Cunha, Celia da, Phan, Jimmy, Wang, Shuling, Collins, Sherilyn, Walker, Amber, Shi, Kai-Xuan, Neumann, Jonathan, Filimban, Ghassan, Shi, Zechuan, Milinkeviciute, Giedre, Javonillo, Dominic I., Tran, Katelynn, Gantuz, Magdalena, Forner, Stefania, Swarup, Vivek, Tenner, Andrea J., LaFerla, Frank M., Wood, Marcelo A., Mortazavi, Ali, MacGregor, Grant R., Green, Kim N.“…This is associated with a suppressed inflammatory response but increased dystrophic neurites and axonal damage as measured by plasma neurofilament light chain (NfL) level. …”
Publicado 2023
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19897“…Nerve conduction studies demonstrated axonal neuropathy. By 2016, he had achieved good disease control with combination methotrexate and sulfasalazine. …”
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19898“…Nerve conduction test revealed severe ongoing axonal degenerative type sensory and motor polyneuropathy in the lower limbs without any upper limb involvement. …”
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19899por Russell, Vivienne A, Oades, Robert D, Tannock, Rosemary, Killeen, Peter R, Auerbach, Judith G, Johansen, Espen B, Sagvolden, Terje“…This insufficiency has implications both for performance and development: H1) In rapidly firing neurons there is deficient ATP production, slow restoration of ionic gradients across neuronal membranes and delayed neuronal firing; H2) In oligodendrocytes insufficient lactate supply impairs fatty acid synthesis and myelination of axons during development. These effects occur over vastly different time scales: those due to deficient ATP (H1) occur over milliseconds, whereas those due to deficient myelination (H2) occur over months and years. …”
Publicado 2006
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19900por Freund, Patrick, Weiskopf, Nikolaus, Ashburner, John, Wolf, Katharina, Sutter, Reto, Altmann, Daniel R, Friston, Karl, Thompson, Alan, Curt, Armin“…INTERPRETATION: Extensive upstream atrophic and microstructural changes of corticospinal axons and sensorimotor cortical areas occur in the first months after spinal cord injury, with faster degenerative changes relating to poorer recovery. …”
Publicado 2013
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