“…Results from our effort to engineer a model of BBC expressing alterations of EGFR, p53 and PTEN suggest that these changes are cooperative and likely play a causal role in basal-like breast cancer pathogenesis. …”
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“…Furthermore, identified six genes (TSPYL5, CD55, CCNE2, DCK, BBC3, and MUC1) susceptible to breast cancer were verified through the literature mining, GO analysis, and pathway functional enrichment analysis. …”
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“…Apoptotic signaling was affected rather modestly, especially in p53 downstream targets (e.g., BCL2, BBC3, and GADD45). Strikingly, the cell-protective heat shock protein HSP27 was strongly upregulated (p < 0.001). …”
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“…HCD caused significant increase in the mRNA expression of transforming growth factor beta (TGF-β), Mothers Against Decapentaplegic Homolog 2 (Smad-2), Mothers Against Decapentaplegic Homolog 4 (Smad-4), Bcl-2-binding component 3 (Bbc3), caspase-3, P53 and Interleukin-6 (IL-6) and decrease in the expression levels of Cyclin depended kinase inhibitor (P21) and Interleukin-3 (IL-3) in hepatic cells. …”
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“…The antibodies received the grades AAA to BBC ( www.ngs-qc.org). We propose to attribute such quantitative grading of all antibodies attributed with the label “ChIP-seq grade”.…”
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“…Aim21 has four polyproline regions and is recruited by two SH3-containing patch proteins, Bbc1 and Abp1. The C-terminal region, which is required for its function, binds Tda2. …”
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“…Expression of the dominant-negative p53 R248W mutant due to TM significantly reduced the transactivation of several established p53 target genes that mediate the tumor-suppressor function, including CDKN1A (p21) and BBC3 (PUMA). This resulted in deregulated signaling through the retinoblastoma protein and loss of G1/S cell-cycle checkpoint function. …”
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“…Victor uses qualitative data from 12,000 adults aged 60+ collected as part of the BBC loneliness experiment to examine the terms used to describe loneliness and to identify both the opposite of loneliness and the positive aspects of loneliness. …”
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“…In this field, we focused on the evaluation of a Ru(III) complex—named AziRu—incorporated into a suite of both zwitterionic and cationic nucleolipid nanosystems, which proved to be very effective for the in vivo targeting of breast cancer cells (BBC). Mechanisms of action have been widely explored in the context of preclinical evaluations in vitro, highlighting a multitarget action on cell death pathways which are typically deregulated in neoplasms onset and progression. …”
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“…In this study, we analyzed 844 mitochondrial DNA D-loop sequences, including 346 de novo sequences and 498 previously published sequences from 20 BBC breeds. We detected a generally high level of genetic diversity among the BBCs, with average haplotype and nucleotide diversities of 0.917 ± 0.0049 and 0.01422, respectively. …”
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“…The study site, Blackbird Creek (BBC) is a tidal wetland that experiences agricultural, fishing, recreational, residential and other anthropogenic activities throughout the year. …”
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“…The results indicate that all four RD monomers possess high bio-based carbon content (BBC) ranging from 63.2 to 76.9% and low volatilities (less than 7 wt% loss after being held isothermally at 30 °C for 5 h). …”
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“…Reporter assays revealed that the RASSF1 promoter is responsive to ATF4, while ablation of RASSF1 mitigated the expression of the ATF4 effector BBC3 and abrogated tunicamycin‐induced apoptosis. …”
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“…Moore pounded out hundreds of books as well as served as presenter of the BBC’s TV program “Sky at Night” program for 55 years (a world record).  …”
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“…However, we observe cases where rigid body domains are oriented incorrectly, as for ciliary protein BBC118, suggesting that combining structure prediction with experimental information will better reveal biologically relevant conformations.…”
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“…Here, we consider patterns of parental income and its association with the sexual behavior of their adult children in a large online study (the BBC internet study). There were curvilinear relationships with parental income in male and female children. …”
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“…In this study, we selected 12 sound sources that are most typically present in classical Chinese gardens based on extensive literature research on Chinese classical poetry, and acquired respective audio samples from the BBC’s library of Sound Effects. Through the spectrogram analyses, pitch detection algorithm and LSTM audio classification methods, the sound sources were classified into discrete sound sources with pitch variation and continuous sound sources with spectral characteristics of white noise or pink noise. …”
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“…SETTING: UK television channels BBC (Call The Midwife and This Is Going To Hurt) and Channel 4 (One Born Every Minute). …”
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